SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 11 LEU A 213
ALA A 217
LEU A 173
LEU A 170
VAL A 158
 None
 1.12A 1ictA-4dx2A:
undetectable
1ictC-4dx2A:
undetectable		 1ictA-4dx2A:
20.25
1ictC-4dx2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		3 / 3 ASP A 347
LYS A 352
ARG A 355
 None
 1.03A 1ra8A-4dx2A:
undetectable		 1ra8A-4dx2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 12 GLN A 297
LEU A 304
LEU A 291
THR A 295
LEU A 242
 None
 1.25A 3fsuA-4dx2A:
undetectable		 3fsuA-4dx2A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 11 ALA A 377
ILE A 385
GLY A 384
THR A 339
ALA A 332
 None
 1.16A 3kw2A-4dx2A:
undetectable		 3kw2A-4dx2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 11 ALA A 377
ILE A 385
GLY A 384
THR A 339
ALA A 332
 None
 1.19A 3kw2B-4dx2A:
undetectable		 3kw2B-4dx2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		4 / 8 TYR A 236
PHE A 272
ILE A 244
PHE A 231
 ATP  A 502 (-3.3A)
None
None
ATP  A 502 ( 4.3A)
 0.73A 3uqbA-4dx2A:
undetectable		 3uqbA-4dx2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 11 ALA A 198
LEU A 195
LEU A 214
LEU A 256
LEU A 257
 None
 0.98A 4wg0C-4dx2A:
undetectable
4wg0D-4dx2A:
undetectable
4wg0E-4dx2A:
undetectable		 4wg0C-4dx2A:
8.40
4wg0D-4dx2A:
8.40
4wg0E-4dx2A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 213
LEU A 199
ALA A 198
THR A 190
ALA A 241
 None
 1.23A 4x1kA-4dx2A:
undetectable
4x1kB-4dx2A:
undetectable		 4x1kA-4dx2A:
19.08
4x1kB-4dx2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 348
ALA A 293
LEU A 325
LEU A 328
LEU A 289
 None
 1.22A 4zn7A-4dx2A:
undetectable		 4zn7A-4dx2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens) 		4 / 7 ILE A 300
GLN A 297
GLU A 247
VAL A 254
 None
 1.07A 6j20A-4dx2A:
undetectable		 6j20A-4dx2A:
19.95