SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ARG A  10
ASP A  93
LEU A  31
GLY A  30
 None
 0.83A 1rtsB-4dx3A:
undetectable		 1rtsB-4dx3A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 6 GLU A  42
LEU A   6
ARG A 393
PHE A 394
 None
 1.04A 1s8fB-4dx3A:
undetectable		 1s8fB-4dx3A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		5 / 12 MET A 247
THR A 269
LEU A 270
PHE A 276
LEU A 279
 None
 1.35A 2mjiA-4dx3A:
undetectable		 2mjiA-4dx3A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		3 / 3 SER A 329
GLU A 343
ASP A 291
 None
SNN  A 319 ( 3.8A)
None
 0.82A 2zthA-4dx3A:
undetectable		 2zthA-4dx3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 8 SER A 251
THR A 282
ALA A 258
ALA A 257
 None
 0.79A 3ax9B-4dx3A:
undetectable		 3ax9B-4dx3A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		3 / 3 SER A 329
GLU A 343
ASP A 291
 None
SNN  A 319 ( 3.8A)
None
 0.84A 3bwyA-4dx3A:
undetectable		 3bwyA-4dx3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		5 / 12 THR A  24
PHE A  87
VAL A  20
VAL A  53
VAL A 324
 None
 1.25A 3dl9A-4dx3A:
undetectable		 3dl9A-4dx3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 8 SER A 251
THR A 282
ALA A 258
ALA A 257
 None
 0.81A 3ns1L-4dx3A:
undetectable		 3ns1L-4dx3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ASP A 243
SER A 265
TYR A 118
HIS A 318
 None
None
None
SNN  A 319 ( 3.0A)
 1.37A 4arcA-4dx3A:
1.3		 4arcA-4dx3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		5 / 10 LEU A  91
ILE A  89
ILE A  94
GLY A 375
PHE A  87
 None
 0.91A 4fakA-4dx3A:
undetectable		 4fakA-4dx3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		5 / 11 VAL A 215
ILE A 264
LEU A 223
ALA A 262
SER A 260
 None
 1.31A 4m83A-4dx3A:
undetectable		 4m83A-4dx3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN
(Agrobacterium
fabrum) 		4 / 6 SER A 299
GLU A 300
GLY A  30
GLY A  32
 None
 0.89A 5cdnA-4dx3A:
undetectable
5cdnB-4dx3A:
undetectable		 5cdnA-4dx3A:
23.50
5cdnB-4dx3A:
18.59