SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 THR H 153
GLU H  55
THR H  56
HIS H  38
 None
 1.20A 1d4fA-4dx8H:
undetectable		 1d4fA-4dx8H:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 THR H 153
GLU H  55
THR H  56
HIS H  38
 None
 1.08A 1d4fB-4dx8H:
undetectable		 1d4fB-4dx8H:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 THR H 153
GLU H  55
THR H  56
HIS H  38
 None
 1.21A 1d4fD-4dx8H:
undetectable		 1d4fD-4dx8H:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL H  92
VAL H  14
ILE H  68
ARG H 179
 None
 1.03A 1iepA-4dx8H:
undetectable		 1iepA-4dx8H:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 12 SER H 115
LEU H 135
LEU H  53
LEU H 110
MET H  94
 None
 1.42A 1p33A-4dx8H:
undetectable		 1p33A-4dx8H:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 12 SER H 115
LEU H 135
LEU H  53
LEU H 110
MET H  94
 None
 1.37A 1p33B-4dx8H:
undetectable		 1p33B-4dx8H:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL H  92
VAL H  14
ILE H  68
ARG H 179
 None
 1.01A 3mssB-4dx8H:
undetectable		 3mssB-4dx8H:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE H 158
LEU H  37
LYS H  51
HIS H 148
 None
 1.01A 5jmnB-4dx8H:
undetectable		 5jmnB-4dx8H:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU H 157
LEU H 160
TRP H 163
 None
 0.85A 5nwuA-4dx8H:
undetectable		 5nwuA-4dx8H:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4dx8 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 ALA H 159
LYS H  95
PHE H  97
ILE H 112
 None
BR  H 301 (-3.2A)
None
None
 0.92A 5of1B-4dx8H:
undetectable		 5of1B-4dx8H:
18.54