SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.90A 1e06A-4dxbA:
undetectable		 1e06A-4dxbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 SER A 426
LYS A 429
SER A 486
ASN A 488
GLU A 522
 None
 0.39A 1i2wB-4dxbA:
22.1		 1i2wB-4dxbA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.06A 1wopA-4dxbA:
0.6		 1wopA-4dxbA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		6 / 12 SER A 426
LYS A 429
SER A 486
ASN A 488
GLU A 522
ASN A 526
 None
 0.53A 1ymxA-4dxbA:
22.5		 1ymxA-4dxbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		6 / 12 SER A 426
LYS A 429
SER A 486
ASN A 488
GLU A 522
ASN A 526
 None
 0.51A 1ymxB-4dxbA:
22.4		 1ymxB-4dxbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		3 / 3 LYS A 593
ASP A 321
ASP A 359
 None
 1.07A 2br4A-4dxbA:
undetectable		 2br4A-4dxbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 6 LEU A 494
MET A 542
MET A 511
LEU A 549
 None
 1.08A 2oz7A-4dxbA:
undetectable		 2oz7A-4dxbA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 546
LEU A 549
LEU A 555
ILE A 334
LEU A 447
 None
 0.99A 2pnjA-4dxbA:
undetectable		 2pnjA-4dxbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.07A 2q6oA-4dxbA:
undetectable		 2q6oA-4dxbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.06A 2ve3A-4dxbA:
undetectable		 2ve3A-4dxbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
 1.01A 3a51C-4dxbA:
undetectable		 3a51C-4dxbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.91A 3bjwC-4dxbA:
undetectable		 3bjwC-4dxbA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 GLY A 187
ASP A 471
GLY A 182
ASP A 164
GLN A 253
 None
None
None
ZN  A 701 (-2.3A)
ZN  A 701 ( 4.0A)
 1.00A 3bwcB-4dxbA:
undetectable		 3bwcB-4dxbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.34A 3gv1A-4dxbA:
undetectable
3gv1C-4dxbA:
undetectable		 3gv1A-4dxbA:
12.40
3gv1C-4dxbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.33A 3gv1A-4dxbA:
undetectable
3gv1B-4dxbA:
undetectable		 3gv1A-4dxbA:
12.40
3gv1B-4dxbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 VAL A 610
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.05A 3hs6A-4dxbA:
0.0		 3hs6A-4dxbA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 GLU A 153
TYR A 155
MET A 597
TRP A 607
 None
 0.70A 3jyrA-4dxbA:
53.6		 3jyrA-4dxbA:
54.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		6 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
PRO A 107
 None
 1.37A 3ufnA-4dxbA:
undetectable		 3ufnA-4dxbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.09A 4feuB-4dxbA:
undetectable		 4feuB-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.12A 4feuF-4dxbA:
undetectable		 4feuF-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.05A 4fevD-4dxbA:
undetectable		 4fevD-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.09A 4fevF-4dxbA:
undetectable		 4fevF-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.08A 4fewD-4dxbA:
undetectable		 4fewD-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.07A 4fewF-4dxbA:
undetectable		 4fewF-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.09A 4fexB-4dxbA:
undetectable		 4fexB-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.09A 4gkhB-4dxbA:
undetectable		 4gkhB-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.07A 4gkhF-4dxbA:
undetectable		 4gkhF-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.07A 4gkhG-4dxbA:
undetectable		 4gkhG-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.06A 4gkhC-4dxbA:
undetectable
4gkhK-4dxbA:
undetectable		 4gkhC-4dxbA:
19.36
4gkhK-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.10A 4gkiA-4dxbA:
undetectable		 4gkiA-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.15A 4gkiC-4dxbA:
undetectable		 4gkiC-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 164
ASP A 487
GLU A 130
 None
ZN  A 701 (-2.3A)
None
None
 1.10A 4gkiE-4dxbA:
undetectable
4gkiG-4dxbA:
undetectable		 4gkiE-4dxbA:
19.36
4gkiG-4dxbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 VAL A 436
ILE A 498
LEU A 525
LEU A 518
 None
 0.81A 4l1wA-4dxbA:
undetectable		 4l1wA-4dxbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 VAL A 430
ILE A 564
LEU A 550
TRP A 376
ALA A 335
 None
 1.36A 4m11D-4dxbA:
1.3		 4m11D-4dxbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 5 ASN A 185
ALA A 188
GLY A 166
ASP A 487
 None
 1.00A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.95A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 GLY A 324
ALA A 325
GLU A 327
SER A 426
 None
 0.79A 4r1zB-4dxbA:
undetectable		 4r1zB-4dxbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 MET A 603
TRP A 607
TYR A 171
GLU A 595
 None
 1.34A 4r87J-4dxbA:
undetectable
4r87L-4dxbA:
undetectable		 4r87J-4dxbA:
13.58
4r87L-4dxbA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 GLY A 377
ILE A 346
ARG A 547
ALA A 335
PRO A 343
 None
 1.07A 5e72A-4dxbA:
undetectable		 5e72A-4dxbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.83A 5f1aA-4dxbA:
undetectable		 5f1aA-4dxbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.84A 5f1aB-4dxbA:
0.0		 5f1aB-4dxbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 11 PHE A 507
ILE A 440
THR A 556
MET A 511
LEU A 549
 None
 1.03A 5jkwA-4dxbA:
undetectable		 5jkwA-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.87A 5sxqA-4dxbA:
undetectable		 5sxqA-4dxbA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.91A 5sxqB-4dxbA:
undetectable		 5sxqB-4dxbA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.89A 5sxtA-4dxbA:
undetectable		 5sxtA-4dxbA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.89A 5sxtB-4dxbA:
undetectable		 5sxtB-4dxbA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.88A 5syjA-4dxbA:
undetectable		 5syjA-4dxbA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 610
GLY A 191
LEU A 195
THR A 193
 None
 0.91A 5syjB-4dxbA:
undetectable		 5syjB-4dxbA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 4 ARG A 399
THR A 352
GLY A 401
PHE A 422
 None
 1.29A 5uunA-4dxbA:
0.1		 5uunA-4dxbA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 7 THR A 505
PHE A 428
ASP A 535
LEU A 525
 None
 1.14A 5uxcA-4dxbA:
undetectable		 5uxcA-4dxbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		6 / 12 ALA A 609
ALA A 605
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.33A 5w4zA-4dxbA:
undetectable		 5w4zA-4dxbA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		6 / 12 ALA A 609
ALA A 605
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.35A 5w4zB-4dxbA:
undetectable		 5w4zB-4dxbA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 5 LEU A 576
VAL A 347
GLU A 404
LEU A 372
 None
 1.06A 5xooB-4dxbA:
undetectable		 5xooB-4dxbA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 5 ALA A 301
SER A 585
GLY A 584
TYR A  90
 None
 1.20A 5yodB-4dxbA:
undetectable		 5yodB-4dxbA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		4 / 6 LEU A 525
LYS A 429
LEU A 432
LEU A 495
 None
 0.98A 5yvnA-4dxbA:
undetectable		 5yvnA-4dxbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.99A 6ecxA-4dxbA:
undetectable		 6ecxA-4dxbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		3 / 3 VAL A 464
ALA A 481
GLN A 253
 None
None
ZN  A 701 ( 4.0A)
 0.65A 6gb9A-4dxbA:
undetectable		 6gb9A-4dxbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA
(Escherichia
coli) 		5 / 12 GLU A 308
GLY A 300
TYR A  90
VAL A 244
GLY A 228
 None
 1.34A 6gngA-4dxbA:
undetectable		 6gngA-4dxbA:
24.24