SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EII_A_RTLA135_1 (CELLULAR RETINOL-BINDING PROTEIN II)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	4 / 7	TYR A 71 SER A 82 TYR A 177 GLN A 38	None None None CR8 A 63 ( 3.7A)	1.48A	1eiiA-4dxoA: undetectable	1eiiA-4dxoA: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_A_HSMA401_1 (NITROPHORIN 1)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	4 / 4	ASP A 55 LEU A 162 LEU A 137 LEU A 161	None	1.18A	1u18A-4dxoA: undetectable	1u18A-4dxoA: 23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	5 / 12	GLU A 211 ARG A 66 MET A 14 GLY A 27 LEU A 42	CR8 A 63 ( 4.0A) CR8 A 63 ( 3.1A) None None None	1.11A	2jfaB-4dxoA: undetectable	2jfaB-4dxoA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BA0_A_HAEA477_1 (MACROPHAGE METALLOELASTASE)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	3 / 3	HIS A 212 GLU A 211 HIS A 193	None CR8 A 63 ( 4.0A) CR8 A 63 ( 3.4A)	0.79A	3ba0A-4dxoA: undetectable	3ba0A-4dxoA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_B_DEXB247_1 (GLUCOCORTICOID RECEPTOR 2)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	5 / 12	GLY A 20 MET A 14 CYH A 101 VAL A 131 PHE A 125	None	1.44A	3gn8B-4dxoA: undetectable	3gn8B-4dxoA: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_B_NIZB809_1 (CATALASE-PEROXIDASE)	4dxo	LEA X(6) GFP-LIKE PROTEINS (synthetic construct)	4 / 8	VAL A 67 GLY A 29 GLN A 38 THR A 39	None None CR8 A 63 ( 3.7A) None	0.98A	5syjB-4dxoA: undetectable	5syjB-4dxoA: 14.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EII_A_RTLA135_1","CELLULAR RETINOL-BINDING PROTEIN II","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",4,"TYR A  71;SER A  82;TYR A 177;GLN A  38","None;None;None;CR8 A  63 ( 3.7A)","1.48A","1eiiA-4dxoA:undetectable","1eiiA-4dxoA:24.32"],["1U18_A_HSMA401_1","NITROPHORIN 1","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",4,"ASP A  55;LEU A 162;LEU A 137;LEU A 161","None","1.18A","1u18A-4dxoA:undetectable","1u18A-4dxoA:23.04"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",5,"GLU A 211;ARG A  66;MET A  14;GLY A  27;LEU A  42","CR8 A  63 ( 4.0A);CR8 A  63 ( 3.1A);None;None;None","1.11A","2jfaB-4dxoA:undetectable","2jfaB-4dxoA:22.88"],["3BA0_A_HAEA477_1","MACROPHAGE METALLOELASTASE","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",3,"HIS A 212;GLU A 211;HIS A 193","None;CR8 A  63 ( 4.0A);CR8 A  63 ( 3.4A)","0.79A","3ba0A-4dxoA:undetectable","3ba0A-4dxoA:20.00"],["3GN8_B_DEXB247_1","GLUCOCORTICOID RECEPTOR 2","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",5,"GLY A  20;MET A  14;CYH A 101;VAL A 131;PHE A 125","None","1.44A","3gn8B-4dxoA:undetectable","3gn8B-4dxoA:23.53"],["5SYJ_B_NIZB809_1","CATALASE-PEROXIDASE","4dxo","LEA X(6) GFP-LIKE PROTEINS","synthetic construct",4,"VAL A  67;GLY A  29;GLN A  38;THR A  39","None;None;CR8 A  63 ( 3.7A);None","0.98A","5syjB-4dxoA:undetectable","5syjB-4dxoA:14.64"]]