SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		3 / 3 ARG A  12
GLN A 121
PRO A 117
 None
 0.92A 2qhfA-4dxwA:
undetectable		 2qhfA-4dxwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		3 / 3 HIS A  45
GLY A  30
ILE A  29
 None
 0.61A 4k50A-4dxwA:
undetectable		 4k50A-4dxwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		3 / 3 HIS A  45
GLY A  30
ILE A  29
 None
 0.59A 4k50I-4dxwA:
undetectable		 4k50I-4dxwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		3 / 3 ARG A 162
ASP A 159
TRP A 163
 None
 1.06A 4xdqA-4dxwA:
undetectable		 4xdqA-4dxwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		4 / 4 LEU A  47
ARG A 111
ILE A  51
ILE A  22
 None
 1.18A 5dzk2-4dxwA:
undetectable
5dzkM-4dxwA:
undetectable
5dzkN-4dxwA:
undetectable		 5dzk2-4dxwA:
1.92
5dzkM-4dxwA:
21.29
5dzkN-4dxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		4 / 8 TYR A 199
THR A 172
CYH A 207
LEU A 144
 None
None
None
BNG  A 301 ( 4.8A)
 1.41A 5kxiA-4dxwA:
4.1
5kxiB-4dxwA:
4.2		 5kxiA-4dxwA:
21.19
5kxiB-4dxwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		4 / 8 TYR A 199
THR A 172
CYH A 207
LEU A 144
 None
None
None
BNG  A 301 ( 4.8A)
 1.40A 5kxiD-4dxwA:
5.0
5kxiE-4dxwA:
4.2		 5kxiD-4dxwA:
21.19
5kxiE-4dxwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4dxw ION TRANSPORT
PROTEIN
(alpha
proteobacterium
HIMB114) 		4 / 6 ALA A 152
LEU A 154
TYR A 199
SER A 169
 None
 1.09A 5phhA-4dxwA:
undetectable		 5phhA-4dxwA:
19.23