SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 11 GLU A 224
ARG A 208
LEU A 235
HIS A 364
GLY A 229
 None
 1.04A 1cmaA-4dy0A:
undetectable
1cmaB-4dy0A:
undetectable		 1cmaA-4dy0A:
14.78
1cmaB-4dy0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 11 ILE A 362
LEU A 274
PHE A 360
PRO A 379
ILE A 326
 None
 1.01A 1dyrA-4dy0A:
undetectable		 1dyrA-4dy0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		4 / 8 LEU A 235
SER A 233
SER A 231
ASN A 365
 None
 1.06A 1ig3A-4dy0A:
undetectable
1ig3B-4dy0A:
undetectable		 1ig3A-4dy0A:
21.94
1ig3B-4dy0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		4 / 7 LEU A 235
SER A 233
SER A 231
ASN A 365
 None
 1.14A 1ig3A-4dy0A:
undetectable
1ig3B-4dy0A:
undetectable		 1ig3A-4dy0A:
21.94
1ig3B-4dy0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 11 VAL A  69
GLY A  70
GLY A  65
HIS A  37
GLU A   9
 None
 1.32A 1iolA-4dy0A:
undetectable		 1iolA-4dy0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 ASP A 284
LEU A 321
ILE A 155
PHE A 124
SER A 133
 None
 1.29A 1xmuA-4dy0A:
undetectable		 1xmuA-4dy0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 ASP A 284
LEU A 321
ILE A 155
PHE A 124
SER A 133
 None
 1.25A 1xmuB-4dy0A:
undetectable		 1xmuB-4dy0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 ASP A 284
LEU A 321
ILE A 155
PHE A 124
SER A 133
 None
 1.17A 1xomA-4dy0A:
undetectable		 1xomA-4dy0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 LEU A 274
PHE A 358
PHE A 360
ASN A  31
TYR A 227
 None
 1.11A 2w3mA-4dy0A:
undetectable		 2w3mA-4dy0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 LEU A 371
GLU A 224
ASN A 365
MET A 262
ILE A 258
 None
 1.27A 2ydoA-4dy0A:
undetectable		 2ydoA-4dy0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 ILE A 236
LEU A 274
ILE A 223
MET A 262
VAL A 370
 None
 1.06A 2ygnA-4dy0A:
undetectable		 2ygnA-4dy0A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		4 / 7 LEU A  58
VAL A  61
THR A  15
VAL A  19
 None
 0.99A 2zaxA-4dy0A:
undetectable		 2zaxA-4dy0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		4 / 8 ASN A 111
GLU A 118
ASN A 166
TRP A 137
 None
 1.10A 4d39A-4dy0A:
undetectable		 4d39A-4dy0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 10 ILE A 362
LEU A 274
PHE A 360
PRO A 379
ILE A 326
 None
 1.11A 4g8zX-4dy0A:
undetectable		 4g8zX-4dy0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 LEU A 274
PHE A 358
PHE A 360
ASN A  31
TYR A 227
 None
 1.09A 4kebB-4dy0A:
undetectable		 4kebB-4dy0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		3 / 3 LEU A  58
LYS A  55
THR A  54
 None
 0.57A 4lj0A-4dy0A:
undetectable		 4lj0A-4dy0A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 9 ALA A 324
PHE A 372
ASN A  77
ILE A  80
VAL A  81
 None
 1.07A 4r20B-4dy0A:
undetectable		 4r20B-4dy0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		3 / 3 THR A 142
HIS A 319
LEU A 150
 None
GOL  A 404 ( 4.7A)
None
 0.75A 5axdA-4dy0A:
undetectable		 5axdA-4dy0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		3 / 3 HIS A 364
SER A  35
ASN A  77
 None
 0.90A 5cprB-4dy0A:
undetectable		 5cprB-4dy0A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 8 LEU A 371
GLU A 224
ASN A 365
MET A 262
ILE A 258
 None
 1.19A 5mzjA-4dy0A:
undetectable		 5mzjA-4dy0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 GLY A 374
SER A 233
ILE A 232
VAL A 370
LEU A 371
 None
 0.74A 5wyqA-4dy0A:
undetectable		 5wyqA-4dy0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 12 GLY A 374
SER A 233
ILE A 232
VAL A 370
LEU A 371
 None
 0.86A 5zhmB-4dy0A:
undetectable		 5zhmB-4dy0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens) 		5 / 11 LEU A 173
HIS A 228
GLY A 229
SER A 231
PHE A 170
 None
 1.04A 6ieyA-4dy0A:
undetectable
6ieyB-4dy0A:
undetectable		 6ieyA-4dy0A:
20.10
6ieyB-4dy0A:
20.10