SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  72
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.49A 1a4lA-4dykA:
21.2		 1a4lA-4dykA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.45A 1a4lA-4dykA:
21.2		 1a4lA-4dykA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.44A 1a4lB-4dykA:
21.1		 1a4lB-4dykA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		6 / 12 HIS A  72
HIS A  74
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.48A 1a4lC-4dykA:
21.1		 1a4lC-4dykA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.43A 1a4lD-4dykA:
20.9		 1a4lD-4dykA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.83A 1e7bA-4dykA:
undetectable		 1e7bA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.85A 1e7bB-4dykA:
undetectable		 1e7bB-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 344
ALA A 345
ALA A 330
GLU A 295
 None
 0.90A 1e7cA-4dykA:
undetectable		 1e7cA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 309
HIS A  74
HIS A 258
HIS A 221
 ZN  A 501 (-2.6A)
ZN  A 501 (-3.2A)
None
ZN  A 501 (-3.3A)
 0.97A 1ei6A-4dykA:
undetectable		 1ei6A-4dykA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 401
ASP A 318
ASP A 378
 None
 0.78A 1eizA-4dykA:
undetectable		 1eizA-4dykA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 401
ASP A 318
ASP A 378
 None
 0.78A 1ej0A-4dykA:
undetectable		 1ej0A-4dykA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 322
ALA A  71
SER A 130
HIS A  74
 MG  A 502 (-4.4A)
None
None
ZN  A 501 (-3.2A)
 1.36A 1errA-4dykA:
undetectable
1errB-4dykA:
undetectable		 1errA-4dykA:
20.93
1errB-4dykA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 TRP A  98
GLU A 101
LEU A 157
HIS A 194
ILE A  97
 None
 1.10A 1kyvA-4dykA:
undetectable
1kyvE-4dykA:
undetectable		 1kyvA-4dykA:
18.14
1kyvE-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  97
TRP A  98
GLU A 101
LEU A 157
HIS A 194
 None
 1.12A 1kyvA-4dykA:
undetectable
1kyvB-4dykA:
undetectable		 1kyvA-4dykA:
18.14
1kyvB-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  97
TRP A  98
GLU A 101
LEU A 157
HIS A 194
 None
 1.11A 1kyvB-4dykA:
undetectable
1kyvC-4dykA:
undetectable		 1kyvB-4dykA:
18.14
1kyvC-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  97
TRP A  98
GLU A 101
LEU A 157
HIS A 194
 None
 1.11A 1kyvC-4dykA:
undetectable
1kyvD-4dykA:
undetectable		 1kyvC-4dykA:
18.14
1kyvD-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  97
TRP A  98
GLU A 101
LEU A 157
HIS A 194
 None
 1.10A 1kyvD-4dykA:
undetectable
1kyvE-4dykA:
undetectable		 1kyvD-4dykA:
18.14
1kyvE-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  34
LEU A  64
GLY A  37
GLY A 410
LEU A  12
 None
 0.89A 1liiA-4dykA:
2.3		 1liiA-4dykA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 163
ALA A 164
VAL A 156
ILE A 171
GLY A 174
 None
 0.81A 1n49B-4dykA:
undetectable		 1n49B-4dykA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 163
ALA A 164
VAL A 156
ILE A 171
GLY A 174
 None
 0.82A 1n49C-4dykA:
undetectable		 1n49C-4dykA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 125
ILE A  17
LEU A  27
VAL A  26
LEU A 394
 None
 1.17A 1r30A-4dykA:
7.5		 1r30A-4dykA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 125
ILE A  17
LEU A  27
VAL A  26
LEU A 394
 None
 1.16A 1r30B-4dykA:
7.1		 1r30B-4dykA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 346
ALA A 349
LEU A  68
ASN A  70
ALA A 326
 None
 1.14A 1sa1A-4dykA:
undetectable
1sa1B-4dykA:
undetectable		 1sa1A-4dykA:
22.82
1sa1B-4dykA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 346
ALA A 349
LEU A  68
ASN A  70
ALA A 326
 None
 1.17A 1sa1C-4dykA:
undetectable
1sa1D-4dykA:
undetectable		 1sa1C-4dykA:
22.82
1sa1D-4dykA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 187
GLY A 358
VAL A 143
VAL A 152
ALA A 153
 None
 1.03A 1vptA-4dykA:
undetectable		 1vptA-4dykA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  98
THR A 198
TYR A 197
 None
 0.60A 2a3aA-4dykA:
6.6		 2a3aA-4dykA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  98
THR A 198
TYR A 197
 None
 0.55A 2a3aB-4dykA:
6.7		 2a3aB-4dykA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  98
THR A 198
TYR A 197
 None
 0.63A 2a3bA-4dykA:
6.7		 2a3bA-4dykA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 131
GLY A 113
VAL A 143
ILE A 139
 None
 0.97A 2aoiA-4dykA:
undetectable		 2aoiA-4dykA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  64
LEU A  12
ALA A  40
ILE A  39
ALA A 372
 None
 1.06A 2bxcA-4dykA:
undetectable		 2bxcA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 344
ALA A 342
ALA A 345
ALA A 330
GLU A 295
 None
 1.05A 2bxeB-4dykA:
undetectable		 2bxeB-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 287
HIS A 221
HIS A  74
THR A 308
GLU A 322
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
None
MG  A 502 (-4.4A)
 1.29A 2dttD-4dykA:
undetectable
2dttE-4dykA:
undetectable		 2dttD-4dykA:
13.73
2dttE-4dykA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 353
LEU A 359
GLY A 358
ILE A 306
ALA A  71
 None
 0.91A 2fk8A-4dykA:
undetectable		 2fk8A-4dykA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 353
THR A 350
ALA A 349
LEU A 340
THR A 323
 None
 1.22A 2npnA-4dykA:
undetectable		 2npnA-4dykA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 287
HIS A  72
HIS A  74
HIS A 221
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 0.92A 2ow9A-4dykA:
undetectable		 2ow9A-4dykA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		6 / 12 HIS A  72
HIS A  74
HIS A 221
GLU A 224
HIS A 258
ASP A 309
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.37A 2pgrA-4dykA:
22.2		 2pgrA-4dykA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 221
HIS A 258
GLY A 307
HIS A  72
HIS A  74
 ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
 1.12A 2pgrA-4dykA:
22.2		 2pgrA-4dykA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 309
HIS A 258
SER A 289
LEU A 287
 ZN  A 501 (-2.6A)
None
None
None
 0.95A 2q0iA-4dykA:
undetectable		 2q0iA-4dykA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 309
HIS A  72
HIS A 258
SER A 289
LEU A 287
 ZN  A 501 (-2.6A)
ZN  A 501 (-3.3A)
None
None
None
 1.03A 2q0jB-4dykA:
undetectable		 2q0jB-4dykA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 309
HIS A 194
HIS A 258
SER A 289
LEU A 287
 ZN  A 501 (-2.6A)
None
None
None
None
 0.97A 2q0jB-4dykA:
undetectable		 2q0jB-4dykA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 294
ARG A 355
GLY A 353
ALA A 356
 None
 0.94A 2xh9A-4dykA:
undetectable		 2xh9A-4dykA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 MET A 348
CYH A 292
PRO A 281
 None
 1.06A 3h52C-4dykA:
undetectable		 3h52C-4dykA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 287
HIS A  72
HIS A  74
HIS A 221
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 0.99A 3kecA-4dykA:
undetectable		 3kecA-4dykA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 142
VAL A 148
PHE A 129
GLU A 115
 None
 1.50A 3n61A-4dykA:
0.3
3n61B-4dykA:
0.1		 3n61A-4dykA:
23.24
3n61B-4dykA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 395
ALA A 349
LEU A 346
LEU A  63
ILE A 278
 None
 0.94A 3ozwB-4dykA:
undetectable		 3ozwB-4dykA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A 323
GLY A 321
THR A 308
GLY A 307
ASP A 316
 None
None
None
None
MG  A 502 (-2.7A)
 1.36A 3t8nD-4dykA:
undetectable
3t8nF-4dykA:
undetectable		 3t8nD-4dykA:
15.08
3t8nF-4dykA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  27
GLY A  33
ALA A  48
PHE A   8
 None
 0.99A 3tehB-4dykA:
undetectable		 3tehB-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 380
GLY A 381
GLN A 385
 None
 0.49A 3v4tH-4dykA:
undetectable		 3v4tH-4dykA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  74
ASP A  86
ASP A 309
ASN A 315
 ZN  A 501 (-3.2A)
None
ZN  A 501 (-2.6A)
GOL  A 503 ( 4.9A)
 0.95A 3vywA-4dykA:
undetectable		 3vywA-4dykA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 311
ARG A  81
GLY A  82
LEU A  83
ILE A  97
 None
 1.28A 3wdmA-4dykA:
undetectable		 3wdmA-4dykA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 287
HIS A  72
HIS A  74
HIS A 221
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 0.92A 4a7bA-4dykA:
undetectable		 4a7bA-4dykA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 221
GLU A 224
HIS A 258
SER A 283
ASP A 309
 ZN  A 501 (-3.3A)
None
None
None
ZN  A 501 (-2.6A)
 0.43A 4aqlA-4dykA:
44.3		 4aqlA-4dykA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  12
LEU A  32
ALA A  31
MET A  49
ALA A  53
 None
 1.09A 4fn9A-4dykA:
undetectable		 4fn9A-4dykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 362
LEU A 359
LEU A 357
GLN A 255
ALA A 216
 None
 1.10A 4fn9A-4dykA:
undetectable		 4fn9A-4dykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 174
ILE A 207
LYS A 203
GLN A 206
 None
 0.86A 4ma8C-4dykA:
undetectable		 4ma8C-4dykA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
HIS A 258
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.44A 4r88A-4dykA:
34.6		 4r88A-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.49A 4r88B-4dykA:
35.3		 4r88B-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.51A 4r88C-4dykA:
34.7		 4r88C-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.49A 4r88D-4dykA:
34.6		 4r88D-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.50A 4r88E-4dykA:
34.5		 4r88E-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  74
HIS A 221
GLU A 224
LEU A 287
ASP A 309
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
None
None
ZN  A 501 (-2.6A)
 0.50A 4r88F-4dykA:
34.8		 4r88F-4dykA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 329
ASN A 284
PRO A 281
ARG A 344
 None
 0.95A 4yv5B-4dykA:
undetectable		 4yv5B-4dykA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 329
ASN A 284
PRO A 281
ARG A 344
 None
 0.95A 4yv5A-4dykA:
undetectable		 4yv5A-4dykA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 275
GLY A 251
ILE A 207
GLY A 248
 None
 0.83A 5alcL-4dykA:
undetectable		 5alcL-4dykA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 298
GLU A 295
ASP A 341
 None
 1.02A 5gqbA-4dykA:
6.7		 5gqbA-4dykA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 133
ILE A 110
ILE A 139
ILE A 118
 None
 0.89A 5murB-4dykA:
undetectable		 5murB-4dykA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 395
VAL A  26
SER A 392
ALA A 342
ALA A 327
 None
 1.08A 5n0oB-4dykA:
undetectable		 5n0oB-4dykA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 255
GLN A 151
PRO A 193
ALA A 153
 None
 1.20A 5odcA-4dykA:
0.8
5odcG-4dykA:
0.8		 5odcA-4dykA:
22.47
5odcG-4dykA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 193
ALA A 153
GLN A 255
GLN A 151
 None
 1.21A 5odcA-4dykA:
undetectable
5odcG-4dykA:
undetectable		 5odcA-4dykA:
22.47
5odcG-4dykA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4dyk AMIDOHYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 197
HIS A 221
MET A 220
 None
ZN  A 501 (-3.3A)
None
 1.12A 6af6A-4dykA:
undetectable		 6af6A-4dykA:
22.85