SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 ALA A 395
LEU A 464
SER A 467
LEU A 390
ILE A 391
 None
 1.26A 1g5yC-4dyoA:
undetectable		 1g5yC-4dyoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 SER A 268
SER A 344
ALA A  93
ILE A 417
 None
 1.13A 1pnlA-4dyoA:
undetectable
1pnlB-4dyoA:
undetectable		 1pnlA-4dyoA:
15.91
1pnlB-4dyoA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
 None
 1.06A 1z11A-4dyoA:
undetectable		 1z11A-4dyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
 None
 1.07A 1z11C-4dyoA:
undetectable		 1z11C-4dyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 10 VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
 None
 1.06A 1z11D-4dyoA:
undetectable		 1z11D-4dyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 224
LEU A 228
GLY A 138
ALA A 137
ALA A 243
 None
 1.17A 2bm9C-4dyoA:
undetectable		 2bm9C-4dyoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 224
LEU A 228
GLY A 138
ALA A 137
ALA A 243
 None
 1.19A 2bm9D-4dyoA:
undetectable		 2bm9D-4dyoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 426
LEU A 427
GLY A  87
ALA A 336
ALA A 332
 None
 0.98A 2bm9F-4dyoA:
undetectable		 2bm9F-4dyoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 HIS A 216
MET A 221
MET A 238
 None
 1.06A 2vj1A-4dyoA:
undetectable		 2vj1A-4dyoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLU A 301
THR A 416
ASP A 264
GLY A 123
HIS A 440
 SD4  A 504 (-2.7A)
None
ZN  A 502 (-2.4A)
None
ZN  A 501 (-3.3A)
 1.39A 3ce6D-4dyoA:
undetectable		 3ce6D-4dyoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 11 HIS A  94
ASP A 264
GLU A 301
GLU A 302
GLY A 414
HIS A 440
 ZN  A 502 ( 3.4A)
ZN  A 502 (-2.4A)
SD4  A 504 (-2.7A)
ZN  A 501 (-2.0A)
SD4  A 504 (-3.4A)
ZN  A 501 (-3.3A)
 0.41A 4pqaA-4dyoA:
21.6		 4pqaA-4dyoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 380
GLU A 301
TYR A 381
 None
SD4  A 504 (-2.7A)
SD4  A 504 (-4.7A)
 1.00A 4r29D-4dyoA:
undetectable		 4r29D-4dyoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 ILE A  74
LEU A  90
LEU A 320
ILE A 323
 None
 0.79A 4rmjA-4dyoA:
undetectable		 4rmjA-4dyoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 LEU A 240
LEU A 154
VAL A 155
PHE A  32
 None
 1.15A 4uswA-4dyoA:
undetectable		 4uswA-4dyoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ASP A 431
THR A 416
THR A 415
TYR A 381
 None
None
None
SD4  A 504 (-4.7A)
 1.30A 4w5qA-4dyoA:
undetectable		 4w5qA-4dyoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ASP A 431
THR A 416
THR A 415
TYR A 381
 None
None
None
SD4  A 504 (-4.7A)
 1.28A 4w5rA-4dyoA:
undetectable		 4w5rA-4dyoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 ASP A 431
THR A 416
THR A 415
TYR A 381
 None
None
None
SD4  A 504 (-4.7A)
 1.31A 4w5tA-4dyoA:
undetectable		 4w5tA-4dyoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 6 CYH A 241
ASN A 300
GLU A 239
TYR A 121
 None
 1.45A 4wcxC-4dyoA:
undetectable		 4wcxC-4dyoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 LEU A 240
GLU A 237
LEU A 228
HIS A  33
 None
 1.35A 4xi3B-4dyoA:
undetectable		 4xi3B-4dyoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 4 GLY A  92
LEU A  42
PHE A  65
ILE A  73
 None
 0.82A 4xv2A-4dyoA:
undetectable		 4xv2A-4dyoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 LEU A 240
ARG A 101
ARG A 104
 None
 0.88A 4yiaB-4dyoA:
undetectable		 4yiaB-4dyoA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLU A 444
LEU A 100
LEU A 134
THR A 135
PRO A 261
 None
 1.31A 5hnxB-4dyoA:
3.6		 5hnxB-4dyoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.98A 5sxqA-4dyoA:
undetectable		 5sxqA-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.96A 5sxtA-4dyoA:
undetectable		 5sxtA-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.97A 5sxtB-4dyoA:
0.0		 5sxtB-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 8 GLU A 239
GLY A 138
GLN A 152
LEU A 154
 None
 0.98A 5syjB-4dyoA:
undetectable		 5syjB-4dyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 MET A 439
ASP A 346
ARG A 380
 SD4  A 504 ( 3.7A)
ZN  A 502 ( 2.0A)
None
 1.18A 5z6jA-4dyoA:
undetectable		 5z6jA-4dyoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 MET A 439
ASP A 346
ARG A 380
 SD4  A 504 ( 3.7A)
ZN  A 502 ( 2.0A)
None
 1.13A 5z6kA-4dyoA:
undetectable		 5z6kA-4dyoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 7 SER A 268
SER A 434
GLY A 450
LEU A 432
 None
 1.09A 6btxA-4dyoA:
undetectable		 6btxA-4dyoA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 4 HIS A 359
VAL A 372
LEU A 405
ALA A 350
 None
 0.89A 6d8pB-4dyoA:
2.3		 6d8pB-4dyoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 337
HIS A 291
VAL A 292
PHE A 461
PHE A 465
 None
 1.35A 6j21A-4dyoA:
undetectable		 6j21A-4dyoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 ASP A 278
LEU A 455
ARG A  10
 None
 0.90A 7dfrA-4dyoA:
undetectable		 7dfrA-4dyoA:
13.40