SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.83A 1mz9A-4dyxA:
undetectable		 1mz9A-4dyxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.84A 1mz9C-4dyxA:
undetectable		 1mz9C-4dyxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		5 / 11 GLU A  62
HIS A  65
LEU A 106
GLU A 107
SER A 113
 CU  A 204 ( 2.3A)
CU  A 203 (-3.2A)
None
CU  A 204 (-1.9A)
None
 1.22A 1rnrA-4dyxA:
9.1		 1rnrA-4dyxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		4 / 7 PHE A 170
PHE A  51
LYS A  53
TYR A  54
 None
 0.74A 3em0B-4dyxA:
undetectable		 3em0B-4dyxA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  72
 None
 0.92A 4ltwA-4dyxA:
undetectable		 4ltwA-4dyxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4dyx FERRITIN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ALA A  66
GLU A 140
LEU A 114
ILE A 133
TYR A  12
 None
 1.46A 5vlmA-4dyxA:
undetectable		 5vlmA-4dyxA:
21.18