SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 GLY A 176
HIS A 175
HIS A 135
THR A 256
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
UNK  A 408 ( 3.5A)
MN  A 401 ( 4.8A)
 1.43A 1gtnQ-4dz4A:
undetectable
1gtnR-4dz4A:
undetectable		 1gtnQ-4dz4A:
11.56
1gtnR-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 255
ALA A 160
GLY A 176
HIS A 175
HIS A 135
 None
MN  A 401 ( 4.8A)
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
 0.97A 1gtnL-4dz4A:
undetectable
1gtnV-4dz4A:
undetectable		 1gtnL-4dz4A:
11.56
1gtnV-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 7 PHE A  89
ALA A  77
PHE A  31
SER A  73
 None
 1.20A 1lqtA-4dz4A:
undetectable		 1lqtA-4dz4A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 7 PHE A  89
ALA A  77
PHE A  31
SER A  73
 None
 1.21A 1lquA-4dz4A:
2.4		 1lquA-4dz4A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 7 VAL A 196
VAL A 232
TYR A 149
CYH A 245
 None
 1.18A 1t46A-4dz4A:
undetectable		 1t46A-4dz4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 176
HIS A 175
HIS A 135
GLY A 255
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
None
MN  A 401 ( 4.8A)
 0.99A 1utdO-4dz4A:
undetectable
1utdP-4dz4A:
undetectable		 1utdO-4dz4A:
11.56
1utdP-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 7 PHE A 102
LEU A  52
LEU A 173
LEU A  54
 None
 0.85A 3bgdB-4dz4A:
1.7		 3bgdB-4dz4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 5 HIS A 175
ASP A 163
HIS A 161
ASP A 159
 UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.24A 3c0zA-4dz4A:
11.3		 3c0zA-4dz4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 5 HIS A 175
ASP A 242
HIS A 161
ASP A 244
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.23A 3c0zA-4dz4A:
11.3		 3c0zA-4dz4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 144
ILE A 121
THR A 130
SER A  48
ILE A 137
 None
 1.20A 3clbB-4dz4A:
undetectable		 3clbB-4dz4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 144
ILE A 121
THR A 130
SER A  48
TYR A 238
 None
 1.22A 3clbB-4dz4A:
undetectable		 3clbB-4dz4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 HIS A 161
ASP A 163
HIS A 175
GLY A 176
THR A 256
 MN  A 401 (-3.4A)
MN  A 402 (-2.5A)
UNK  A 407 ( 3.8A)
UNK  A 409 ( 3.4A)
UNK  A 408 ( 3.5A)
 0.23A 3gn0A-4dz4A:
30.1		 3gn0A-4dz4A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 HIS A 161
ASP A 163
HIS A 175
GLY A 176
THR A 256
 MN  A 401 (-3.4A)
MN  A 402 (-2.5A)
UNK  A 407 ( 3.8A)
UNK  A 409 ( 3.4A)
UNK  A 408 ( 3.5A)
 0.25A 3gn0B-4dz4A:
30.3		 3gn0B-4dz4A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 144
ILE A 121
THR A 130
SER A  48
ILE A 137
 None
 1.22A 3hbbB-4dz4A:
undetectable		 3hbbB-4dz4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 144
ILE A 121
THR A 130
SER A  48
TYR A 238
 None
 1.21A 3hbbB-4dz4A:
undetectable		 3hbbB-4dz4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		3 / 3 ASP A  87
SER A  19
ARG A  34
 EDO  A 406 (-3.3A)
EDO  A 406 (-3.7A)
None
 0.93A 3loqA-4dz4A:
undetectable		 3loqA-4dz4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 LEU A 141
VAL A 285
VAL A  50
GLY A 132
TYR A 238
 None
 1.49A 3lp0A-4dz4A:
undetectable		 3lp0A-4dz4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  47
VAL A  69
SER A  73
 None
 0.71A 3n8xB-4dz4A:
undetectable		 3n8xB-4dz4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 121
ASP A 283
ASP A 134
LEU A  52
PRO A 140
 None
 1.20A 3q87B-4dz4A:
undetectable		 3q87B-4dz4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 153
ILE A 280
TYR A 149
GLN A 147
ALA A 118
 None
 1.16A 4a83A-4dz4A:
undetectable		 4a83A-4dz4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 10 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.43A 4bz6A-4dz4A:
11.8		 4bz6A-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.42A 4bz6A-4dz4A:
11.8
4bz6B-4dz4A:
11.4		 4bz6A-4dz4A:
21.69
4bz6B-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 10 HIS A 175
ASP A 242
HIS A 161
ASP A 244
PRO A 248
 UNK  A 407 ( 3.8A)
MN  A 401 ( 2.8A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
 1.43A 4bz6D-4dz4A:
11.3		 4bz6D-4dz4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 9 ASP A 242
PRO A 289
ALA A 298
GLY A 255
GLY A  65
 MN  A 401 ( 2.8A)
EDO  A 405 ( 4.7A)
None
None
None
 1.32A 4mm5A-4dz4A:
undetectable		 4mm5A-4dz4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 10 ASP A 242
PRO A 289
ALA A 298
GLY A 255
GLY A  65
 MN  A 401 ( 2.8A)
EDO  A 405 ( 4.7A)
None
None
None
 1.32A 4mmdA-4dz4A:
undetectable		 4mmdA-4dz4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		3 / 3 LYS A 316
ASN A 278
ASP A  44
 None
 0.86A 4o1eA-4dz4A:
undetectable		 4o1eA-4dz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 6 MET A 178
ILE A 231
ILE A 228
VAL A 232
 None
 0.90A 4olmA-4dz4A:
undetectable		 4olmA-4dz4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.11A 4qa0A-4dz4A:
12.0		 4qa0A-4dz4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.11A 4qa2A-4dz4A:
11.8		 4qa2A-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 157
GLY A 176
ASP A 159
HIS A 161
ASP A 244
 None
UNK  A 409 ( 3.4A)
MN  A 402 ( 2.5A)
MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
 1.12A 4qa2B-4dz4A:
11.7		 4qa2B-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 VAL A 271
ILE A 198
ILE A 208
ASN A 209
HIS A 157
 None
 1.06A 4xueA-4dz4A:
undetectable		 4xueA-4dz4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		4 / 5 LEU A 225
PHE A 158
ILE A 228
ILE A 156
 None
 1.09A 5dzk4-4dz4A:
undetectable
5dzkg-4dz4A:
1.5
5dzkm-4dz4A:
1.0
5dzkn-4dz4A:
undetectable		 5dzk4-4dz4A:
1.37
5dzkg-4dz4A:
21.26
5dzkm-4dz4A:
22.53
5dzkn-4dz4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ASP A 292
HIS A 175
ASP A 163
HIS A 161
ASP A 159
 None
UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.20A 5ef8A-4dz4A:
11.7		 5ef8A-4dz4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 ASP A 292
HIS A 175
ASP A 163
HIS A 161
ASP A 159
 None
UNK  A 407 ( 3.8A)
MN  A 402 (-2.5A)
MN  A 401 (-3.4A)
MN  A 402 ( 2.5A)
 1.19A 5ef8B-4dz4A:
11.7		 5ef8B-4dz4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 VAL A  47
VAL A  69
SER A  73
LEU A 268
ALA A 305
 None
 1.05A 5iktA-4dz4A:
undetectable		 5iktA-4dz4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 161
ASP A 244
THR A 254
GLY A 176
HIS A 175
 MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
 1.32A 5m66A-4dz4A:
undetectable		 5m66A-4dz4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 131
GLY A  65
SER A  48
GLY A 133
GLY A 132
 None
 1.00A 5wyqB-4dz4A:
undetectable		 5wyqB-4dz4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4dz4 AGMATINASE
(Burkholderia
thailandensis) 		5 / 12 HIS A 161
ASP A 244
THR A 254
GLY A 176
HIS A 175
 MN  A 401 (-3.4A)
MN  A 401 (-2.0A)
None
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
 1.28A 6f3nB-4dz4A:
2.2		 6f3nB-4dz4A:
22.06