SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 8 HIS A  14
HIS A 358
LEU A 230
HIS A 229
 CD  A 502 (-3.4A)
CD  A 501 (-3.4A)
None
CD  A 502 (-3.6A)
 0.98A 1bzmA-4dziA:
undetectable		 1bzmA-4dziA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		3 / 3 ARG A 381
ASP A 113
ASN A   5
 None
 0.88A 2zzmA-4dziA:
undetectable		 2zzmA-4dziA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		5 / 10 LEU A 120
VAL A 289
ALA A 164
ILE A 163
LEU A 392
 None
 1.19A 3fl9A-4dziA:
undetectable		 3fl9A-4dziA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		5 / 10 LEU A 120
VAL A 289
ALA A 164
ILE A 163
LEU A 392
 None
 1.19A 3fl9F-4dziA:
undetectable		 3fl9F-4dziA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 5 VAL A 198
ILE A 167
PHE A 145
PHE A  22
 None
 0.94A 3owxB-4dziA:
undetectable		 3owxB-4dziA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 6 SER A 206
ASP A 209
ASP A 213
ARG A 282
 None
 1.14A 4eysA-4dziA:
undetectable		 4eysA-4dziA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		3 / 3 GLU A 151
ARG A  24
HIS A  25
 None
 0.84A 4kf9A-4dziA:
undetectable		 4kf9A-4dziA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 7 ALA A 388
ILE A 291
LEU A 190
PHE A 118
 None
 1.06A 4uymA-4dziA:
undetectable		 4uymA-4dziA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 7 ALA A 388
ILE A 291
LEU A 190
PHE A 118
 None
 1.03A 4uymB-4dziA:
undetectable		 4uymB-4dziA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 6 ARG A 300
ARG A 265
ASP A 269
ASP A 264
 SO4  A 506 (-3.7A)
SO4  A 506 (-4.0A)
None
None
 1.16A 4xqeA-4dziA:
undetectable		 4xqeA-4dziA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 6 ARG A 300
ARG A 265
ASP A 269
ASP A 264
 SO4  A 506 (-3.7A)
SO4  A 506 (-4.0A)
None
None
 1.10A 4xqeB-4dziA:
undetectable		 4xqeB-4dziA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 8 ARG A 300
ARG A 265
ASP A 269
ASP A 264
 SO4  A 506 (-3.7A)
SO4  A 506 (-4.0A)
None
None
 1.09A 4xqgA-4dziA:
undetectable		 4xqgA-4dziA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 8 ARG A 300
ARG A 265
ASP A 269
ASP A 264
 SO4  A 506 (-3.7A)
SO4  A 506 (-4.0A)
None
None
 1.09A 4xqgB-4dziA:
undetectable		 4xqgB-4dziA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 6 SER A 169
GLY A  49
ARG A  33
GLY A  34
 None
 0.93A 5cdpA-4dziA:
undetectable
5cdpB-4dziA:
undetectable		 5cdpA-4dziA:
21.06
5cdpB-4dziA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		3 / 3 LEU A 351
PHE A 368
ILE A 350
 None
 0.65A 5dzk1-4dziA:
undetectable
5dzkF-4dziA:
1.7
5dzkM-4dziA:
undetectable		 5dzk1-4dziA:
2.70
5dzkF-4dziA:
19.62
5dzkM-4dziA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 5 ARG A 205
HIS A 212
ALA A 171
ASP A 172
 None
 1.44A 5mfxA-4dziA:
undetectable		 5mfxA-4dziA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 5 LEU A 192
PHE A 228
LEU A 190
PHE A 118
 None
 1.22A 5x1fC-4dziA:
undetectable
5x1fJ-4dziA:
undetectable		 5x1fC-4dziA:
19.91
5x1fJ-4dziA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 5 THR A 281
HIS A 283
ASP A 213
ARG A 210
 None
 1.20A 6dchA-4dziA:
undetectable		 6dchA-4dziA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE
(Mycobacterium
avium) 		4 / 5 ASN A 293
GLY A 124
HIS A 229
ASP A  12
 None
None
CD  A 502 (-3.6A)
CD  A 502 (-2.1A)
 1.09A 6gh9A-4dziA:
undetectable		 6gh9A-4dziA:
11.44