SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
3 / 3 ALA A 253
VAL A 251
TRP A 200
None
0.86A 1bdwA-4dzrA:
undetectable
1bdwB-4dzrA:
undetectable
1bdwA-4dzrA:
7.82
1bdwB-4dzrA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
5 / 12 PRO A 207
PRO A 208
THR A 137
GLY A 136
LEU A 261
None
1.14A 2uvnA-4dzrA:
undetectable
2uvnA-4dzrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
4 / 6 VAL A 251
ARG A 302
VAL A 259
PHE A 283
None
1.38A 3jx4A-4dzrA:
undetectable
3jx4B-4dzrA:
undetectable
3jx4A-4dzrA:
21.11
3jx4B-4dzrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
5 / 12 THR A 112
GLY A 136
ILE A 142
ASN A 206
PRO A 208
None
None
None
CA  A 401 (-3.2A)
None
0.92A 3q87B-4dzrA:
12.0
3q87B-4dzrA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
5 / 12 THR A 112
GLY A 136
SER A 139
ASN A 206
PRO A 208
None
None
None
CA  A 401 (-3.2A)
None
0.91A 3q87B-4dzrA:
12.0
3q87B-4dzrA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
5 / 11 ASP A 134
GLY A 136
GLY A 138
ILE A 142
ASP A 159
None
1.11A 4dcmA-4dzrA:
10.9
4dcmA-4dzrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
4 / 7 ARG A 198
VAL A 251
TRP A 200
GLU A 192
None
0.85A 4jseA-4dzrA:
undetectable
4jseB-4dzrA:
undetectable
4jseA-4dzrA:
21.36
4jseB-4dzrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
4 / 7 GLU A 192
ARG A 198
VAL A 251
TRP A 200
None
0.97A 4jseA-4dzrA:
undetectable
4jseB-4dzrA:
undetectable
4jseA-4dzrA:
21.36
4jseB-4dzrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
5 / 12 GLY A 140
GLY A 102
SER A 139
ALA A 157
ALA A 143
ACT  A 402 ( 4.0A)
GOL  A 403 (-3.8A)
None
ACT  A 402 ( 4.6A)
ACT  A 402 ( 4.5A)
0.93A 4uckA-4dzrA:
5.8
4uckA-4dzrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
4 / 6 VAL A 251
ARG A 302
VAL A 259
PHE A 283
None
1.32A 5addA-4dzrA:
undetectable
5addB-4dzrA:
undetectable
5addA-4dzrA:
21.11
5addB-4dzrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4dzr PROTEIN-(GLUTAMINE-N
5)
METHYLTRANSFERASE,
RELEASE
FACTOR-SPECIFIC

(Alicyclobacillus
acidocaldarius)
4 / 6 VAL A 251
ARG A 302
VAL A 259
PHE A 283
None
1.40A 5adeA-4dzrA:
undetectable
5adeB-4dzrA:
undetectable
5adeA-4dzrA:
21.11
5adeB-4dzrA:
21.11