SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 TYR A 209
TRP A 208
VAL A  96
GLY A 101
GLY A 103
 None
 0.93A 1etrH-4dztA:
undetectable		 1etrH-4dztA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 GLY A  62
LEU A  60
GLY A  64
ARG A  95
 None
 1.49A 1j7kA-4dztA:
undetectable		 1j7kA-4dztA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.31A 1mj2B-4dztA:
undetectable		 1mj2B-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.33A 1mj2D-4dztA:
undetectable		 1mj2D-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.30A 1mjoB-4dztA:
undetectable		 1mjoB-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.24A 1mjoA-4dztA:
undetectable		 1mjoA-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.31A 1mjoD-4dztA:
undetectable		 1mjoD-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 10 ALA A  53
ILE A  78
GLY A  79
GLY A  80
ILE A  42
 None
 0.95A 1sdvA-4dztA:
undetectable		 1sdvA-4dztA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 LEU A 137
VAL A 141
THR A 175
VAL A 153
GLY A 132
 None
None
CA  A 303 (-3.6A)
None
None
 1.14A 2cbrA-4dztA:
undetectable		 2cbrA-4dztA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 PHE A  49
PRO A 226
ALA A 224
ALA A  53
ALA A  93
 None
 1.28A 2x2nA-4dztA:
undetectable		 2x2nA-4dztA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 ILE A 204
LEU A 218
THR A  82
THR A  77
PRO A   7
 None
PMS  A 301 ( 4.3A)
None
None
None
 1.13A 3dcjA-4dztA:
2.9
3dcjB-4dztA:
3.1		 3dcjA-4dztA:
24.29
3dcjB-4dztA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 11 GLY A 103
ASP A  39
ILE A  38
GLY A 130
ILE A 109
 None
 1.14A 3ebzB-4dztA:
undetectable		 3ebzB-4dztA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 LEU A  91
GLY A  30
VAL A 124
PRO A 226
VAL A  35
 None
 1.17A 3gguA-4dztA:
undetectable		 3gguA-4dztA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 11 ARG A  16
GLN A  15
LEU A  18
ALA A 186
LEU A 197
 None
CA  A 302 (-3.5A)
None
None
None
 1.43A 3jwqA-4dztA:
undetectable
3jwqD-4dztA:
undetectable		 3jwqA-4dztA:
19.52
3jwqD-4dztA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 ALA A 136
LEU A 137
VAL A 141
LEU A 129
ALA A 125
 None
 1.00A 3ozuA-4dztA:
2.1		 3ozuA-4dztA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 11 VAL A  74
ALA A  75
GLY A  76
TYR A  83
TYR A 209
 None
 1.45A 3qxyB-4dztA:
undetectable
3qxyQ-4dztA:
undetectable		 3qxyB-4dztA:
20.97
3qxyQ-4dztA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 11 ILE A  42
ALA A  75
GLY A  76
GLU A  48
GLY A  30
 None
 0.96A 4jdsA-4dztA:
undetectable		 4jdsA-4dztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		3 / 4 SER A 206
GLY A 230
GLU A 237
 None
 0.61A 4juoA-4dztA:
undetectable
4juoC-4dztA:
undetectable		 4juoA-4dztA:
20.32
4juoC-4dztA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 9 ALA A  53
ILE A  38
GLY A  41
SER A 206
VAL A  74
 None
 1.15A 4r20B-4dztA:
undetectable		 4r20B-4dztA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 10 ASP A 138
ALA A 154
VAL A 153
SER A 166
GLY A 130
 None
PMS  A 301 (-3.6A)
None
None
None
 1.42A 4xp1A-4dztA:
undetectable		 4xp1A-4dztA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 6 ALA A 224
THR A 225
VAL A 228
VAL A 195
 None
 1.07A 5eckD-4dztA:
undetectable		 5eckD-4dztA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 6 ALA A 224
THR A 225
VAL A 228
VAL A 195
 None
 0.96A 5eclA-4dztA:
undetectable		 5eclA-4dztA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 6 ALA A 224
THR A 225
VAL A 228
VAL A 195
 None
 0.83A 5eclD-4dztA:
undetectable		 5eclD-4dztA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 4 ALA A 207
PRO A 226
LEU A 129
HIS A  70
 None
None
None
PMS  A 301 (-4.2A)
 1.18A 5eskA-4dztA:
undetectable		 5eskA-4dztA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 10 TYR A  24
VAL A  33
ILE A  78
PRO A 122
LEU A  10
 None
 1.01A 5ienB-4dztA:
undetectable		 5ienB-4dztA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		4 / 6 ARG A 185
GLY A 262
SER A 187
THR A 180
 None
 1.01A 5ysiA-4dztA:
undetectable		 5ysiA-4dztA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 9 SER A 274
ALA A  86
GLY A 230
ALA A  28
GLY A  30
 None
 1.21A 6bklE-4dztA:
undetectable
6bklF-4dztA:
undetectable
6bklG-4dztA:
undetectable
6bklH-4dztA:
undetectable		 6bklE-4dztA:
5.43
6bklF-4dztA:
5.43
6bklG-4dztA:
5.43
6bklH-4dztA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4dzt AQUALYSIN-1
(Thermus
aquaticus) 		5 / 12 ALA A  93
LEU A  91
VAL A 231
HIS A 227
ALA A 207
 None
 1.01A 6djzC-4dztA:
undetectable		 6djzC-4dztA:
20.94