SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 167
VAL A 169
HIS A 287
GLY A 165
 None
 0.99A 1ekjA-4e04A:
undetectable
1ekjB-4e04A:
undetectable		 1ekjA-4e04A:
21.43
1ekjB-4e04A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 GLY A  88
PRO A 216
VAL A 217
ILE A 248
 None
 0.84A 2aoiA-4e04A:
undetectable		 2aoiA-4e04A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 203
TYR A 172
GLY A 180
PRO A 200
 LBV  A 400 (-3.8A)
LBV  A 400 (-4.4A)
None
None
 0.90A 2ys6A-4e04A:
undetectable		 2ys6A-4e04A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 CYH A 285
THR A 268
HIS A 256
ILE A 220
VAL A 297
 None
LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
 1.30A 3sp9A-4e04A:
undetectable		 3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 THR A 268
HIS A 256
ILE A 220
VAL A 297
ILE A 271
 LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
None
 1.18A 3sp9A-4e04A:
undetectable		 3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 ILE A  91
ALA A  79
HIS A 109
ARG A 110
 None
 1.34A 4ac9B-4e04A:
undetectable
4ac9C-4e04A:
undetectable		 4ac9B-4e04A:
20.88
4ac9C-4e04A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		4 / 5 ARG A 261
ILE A 223
HIS A 266
GLY A 264
 None
 1.32A 4e7cC-4e04A:
undetectable		 4e7cC-4e04A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 LEU A  59
LEU A  48
LEU A  51
ILE A  41
VAL A  93
 None
 1.23A 4mk4A-4e04A:
undetectable		 4mk4A-4e04A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 173
TRP A 280
ILE A 183
 None
 0.78A 4mwxA-4e04A:
undetectable		 4mwxA-4e04A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 211
ALA A 208
ILE A 283
ALA A 305
PHE A 174
 None
LBV  A 400 ( 3.7A)
None
None
None
 1.13A 5n5dB-4e04A:
undetectable		 5n5dB-4e04A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 PHE A  95
ALA A  58
THR A 231
ILE A  26
LEU A  33
 None
 0.93A 6aybA-4e04A:
undetectable		 6aybA-4e04A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 12 VAL A  93
PRO A 236
VAL A 230
PHE A  95
PHE A  68
 None
 1.38A 6becA-4e04A:
undetectable
6becB-4e04A:
undetectable
6becC-4e04A:
undetectable		 6becA-4e04A:
20.03
6becB-4e04A:
20.03
6becC-4e04A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1
(Rhodopseudomonas
palustris) 		5 / 10 ALA A  64
VAL A  67
PHE A  95
VAL A  93
LEU A  33
 None
 0.82A 6h1lA-4e04A:
undetectable		 6h1lA-4e04A:
21.02