SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		5 / 10 LEU A 149
VAL A  68
GLY A  87
ALA A 102
ILE A 100
 None
 0.90A 3ekpB-4e08A:
undetectable		 3ekpB-4e08A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		5 / 9 LEU A 149
VAL A  68
GLY A  87
ALA A 102
ILE A 100
 None
 0.91A 3el0B-4e08A:
undetectable		 3el0B-4e08A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		5 / 12 GLY A  76
GLY A  72
GLN A  50
VAL A  43
ALA A  42
 None
 1.16A 3t7vA-4e08A:
undetectable		 3t7vA-4e08A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		4 / 6 GLU A  94
ILE A 100
ASN A 148
VAL A 138
 None
 1.08A 4ejwB-4e08A:
undetectable		 4ejwB-4e08A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		3 / 3 VAL A  24
TYR A 159
ALA A 162
 None
 0.44A 4ybnA-4e08A:
undetectable		 4ybnA-4e08A:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4e08 DJ-1 BETA
(Drosophila
melanogaster) 		7 / 10 GLU A  17
GLY A  72
GLY A  73
ILE A 103
ALA A 105
PRO A 107
GLY A 154
 None
 0.23A 6e5zA-4e08A:
35.2		 6e5zA-4e08A:
52.08