SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 11 ALA A 161
PHE A 162
LEU A 197
ILE A 137
PHE A   6
 None
 1.19A 1uduA-4e09A:
undetectable		 1uduA-4e09A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 11 ILE A  80
PHE A   6
ASN A  21
ILE A 166
ILE A  22
 None
None
None
ACP  A 301 (-4.2A)
None
 1.03A 2blaA-4e09A:
4.1		 2blaA-4e09A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 LEU A 136
LEU A 100
LEU A 122
THR A 157
PHE A 112
 None
 1.47A 2oaxA-4e09A:
undetectable		 2oaxA-4e09A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		6 / 12 ILE A 201
PHE A   6
ALA A  60
LEU A  73
ILE A  80
MET A   1
 None
 1.31A 2xkwB-4e09A:
undetectable		 2xkwB-4e09A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 GLY A  14
GLY A  11
THR A 138
PHE A 162
ILE A 102
 ACP  A 301 (-3.2A)
ACP  A 301 (-3.5A)
None
None
None
 0.87A 3elwA-4e09A:
undetectable		 3elwA-4e09A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 10 LEU A   7
ALA A 115
ILE A 154
VAL A 101
ILE A 103
 None
 0.94A 3em3B-4e09A:
undetectable		 3em3B-4e09A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 LEU A   7
ALA A 115
ILE A 154
VAL A 101
ILE A 103
 None
 0.92A 3em6B-4e09A:
undetectable		 3em6B-4e09A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 10 GLY A  14
ALA A  18
ASN A  21
ILE A 194
ILE A 137
 ACP  A 301 (-3.2A)
None
None
None
None
 0.96A 3lzvA-4e09A:
undetectable		 3lzvA-4e09A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 11 PRO A  40
ASP A  39
LEU A  44
VAL A  19
ALA A  18
 None
ACP  A 301 (-3.9A)
None
None
None
 1.31A 3n23C-4e09A:
undetectable		 3n23C-4e09A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 11 LEU A   7
ALA A 115
ILE A 154
VAL A 101
ILE A 103
 None
 0.97A 3oxxD-4e09A:
undetectable		 3oxxD-4e09A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 6 ARG A 134
ILE A 103
VAL A 119
LEU A 122
 None
 0.97A 4em2A-4e09A:
undetectable		 4em2A-4e09A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 8 VAL A  66
TYR A  67
VAL A  36
LEU A   7
 None
 0.94A 4jq1B-4e09A:
2.1		 4jq1B-4e09A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		6 / 12 ILE A 204
ALA A 133
ILE A 103
PHE A 162
LEU A 197
ILE A 201
 None
 1.29A 4m2xA-4e09A:
4.2		 4m2xA-4e09A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 ILE A 204
ALA A 133
ILE A 103
LEU A 197
ILE A 201
 None
 1.05A 4m2xC-4e09A:
4.2		 4m2xC-4e09A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 ILE A 204
ALA A 133
ILE A 103
LEU A 197
ILE A 201
 None
 1.01A 4m2xE-4e09A:
4.3		 4m2xE-4e09A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 6 ILE A 201
ILE A 194
PHE A   6
LEU A 136
 None
 0.94A 4m51A-4e09A:
2.3		 4m51A-4e09A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 GLY A  14
ASN A  21
ILE A 194
ILE A 137
ILE A 154
 ACP  A 301 (-3.2A)
None
None
None
None
 0.92A 4q5mA-4e09A:
undetectable		 4q5mA-4e09A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 4 TYR A 172
THR A  17
GLY A  14
LEU A 136
 ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
ACP  A 301 (-3.2A)
None
 1.49A 4w5nA-4e09A:
4.0		 4w5nA-4e09A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 7 ASP A 187
ARG A 169
GLY A 192
GLU A 193
 None
 0.97A 5btaA-4e09A:
undetectable
5btaC-4e09A:
undetectable
5btaD-4e09A:
2.3		 5btaA-4e09A:
19.32
5btaC-4e09A:
19.32
5btaD-4e09A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 7 ASP A 187
ARG A 169
GLY A 192
GLU A 193
 None
 0.91A 5btgA-4e09A:
undetectable
5btgC-4e09A:
undetectable
5btgD-4e09A:
2.3		 5btgA-4e09A:
19.32
5btgC-4e09A:
19.32
5btgD-4e09A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		3 / 3 ASN A  21
ASP A 187
GLY A 188
 None
 0.61A 5fctB-4e09A:
undetectable		 5fctB-4e09A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 ILE A 102
VAL A  19
GLU A 195
VAL A  35
GLY A  30
 None
 1.09A 5igjA-4e09A:
undetectable		 5igjA-4e09A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  14
GLY A  11
PHE A 162
ILE A 102
 None
ACP  A 301 (-3.2A)
ACP  A 301 (-3.5A)
None
None
 0.90A 5vimA-4e09A:
undetectable		 5vimA-4e09A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  14
GLY A  11
PHE A 162
ILE A 102
 None
ACP  A 301 (-3.2A)
ACP  A 301 (-3.5A)
None
None
 0.88A 5vimB-4e09A:
undetectable		 5vimB-4e09A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4e09 PLASMID PARTITIONING
PROTEIN PARF
(Escherichia
coli) 		4 / 7 ALA A  25
THR A  24
ILE A 166
PRO A 104
 None
None
ACP  A 301 (-4.2A)
None
 0.70A 6cduF-4e09A:
undetectable
6cduJ-4e09A:
undetectable		 6cduF-4e09A:
21.05
6cduJ-4e09A:
21.05