SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		3 / 3 GLU A 155
ILE A 152
ARG A  23
 ACT  A 401 (-3.4A)
None
None
 0.74A 1cd2A-4e0bA:
undetectable		 1cd2A-4e0bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 9 GLY A   7
ASP A  34
ILE A  35
ALA A  77
ILE A  97
 None
 0.42A 1cetA-4e0bA:
33.2		 1cetA-4e0bA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 6 GLN A 303
ASP A 307
VAL A 309
GLY A 305
 None
 1.24A 1ekjC-4e0bA:
undetectable
1ekjD-4e0bA:
undetectable		 1ekjC-4e0bA:
22.78
1ekjD-4e0bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 6 TYR A 252
ASP A 301
VAL A 121
GLY A 176
 None
 1.27A 1ekjC-4e0bA:
undetectable
1ekjD-4e0bA:
undetectable		 1ekjC-4e0bA:
22.78
1ekjD-4e0bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 6 ASP A 301
VAL A 121
GLY A 176
TYR A 252
 None
 1.27A 1ekjC-4e0bA:
undetectable
1ekjD-4e0bA:
undetectable		 1ekjC-4e0bA:
22.78
1ekjD-4e0bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 8 ALA A 129
GLY A 145
ALA A 128
ILE A 116
 None
 0.63A 1gtnI-4e0bA:
undetectable
1gtnJ-4e0bA:
undetectable		 1gtnI-4e0bA:
15.81
1gtnJ-4e0bA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 4 ILE A  49
LEU A  46
VAL A  42
ALA A  36
 None
 0.95A 1mz9A-4e0bA:
undetectable		 1mz9A-4e0bA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 5 ILE A  49
LEU A  46
VAL A  42
ALA A  36
 None
 0.98A 1mz9C-4e0bA:
undetectable		 1mz9C-4e0bA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 GLY A   7
VAL A  98
ILE A 116
VAL A  93
ILE A  97
 None
 0.75A 2bpxB-4e0bA:
undetectable		 2bpxB-4e0bA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 ILE A   6
GLY A   7
GLY A  13
ILE A 117
ALA A  77
 None
 1.00A 2fk8A-4e0bA:
6.1		 2fk8A-4e0bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 GLY A   7
VAL A  98
ILE A 116
VAL A  93
ILE A  97
 None
 0.72A 2pynB-4e0bA:
undetectable		 2pynB-4e0bA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		4 / 8 GLY A 257
HIS A 259
ILE A 302
ASN A 299
 None
 0.88A 2x0pA-4e0bA:
undetectable		 2x0pA-4e0bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		3 / 3 LEU A 143
GLU A 130
ILE A 127
 None
 0.53A 3czhA-4e0bA:
undetectable		 3czhA-4e0bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 ILE A  75
GLY A 145
PHE A 144
LEU A 238
LEU A  16
 None
 1.13A 3em0B-4e0bA:
undetectable		 3em0B-4e0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 GLY A   7
VAL A  98
ILE A 116
VAL A  93
ILE A  97
 None
 0.81A 3nduC-4e0bA:
undetectable		 3nduC-4e0bA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 10 ILE A 116
ALA A 102
LEU A 143
LEU A 132
VAL A 131
 None
 1.12A 3o02A-4e0bA:
undetectable
3o02B-4e0bA:
undetectable		 3o02A-4e0bA:
22.71
3o02B-4e0bA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		3 / 3 ARG A  23
LEU A 236
THR A 148
 None
 0.84A 3oxcA-4e0bA:
undetectable		 3oxcA-4e0bA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 10 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.19A 3wdmB-4e0bA:
undetectable		 3wdmB-4e0bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 9 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.02A 3wdmC-4e0bA:
3.8		 3wdmC-4e0bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4e0b MALATE DEHYDROGENASE
(Vibrio
vulnificus) 		5 / 12 ILE A   6
GLY A   7
GLY A  10
ALA A  15
ILE A  35
 None
 0.83A 6iftA-4e0bA:
3.8		 6iftA-4e0bA:
25.00