SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 10 LEU A 150
LEU A 164
THR A 172
THR A   3
ILE A   5
 None
 1.26A 1i18A-4e0fA:
11.0
1i18B-4e0fA:
10.7		 1i18A-4e0fA:
24.29
1i18B-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 10 THR A   3
ILE A   5
LEU A 150
LEU A 164
THR A 172
 None
 1.23A 1i18A-4e0fA:
11.0
1i18B-4e0fA:
10.7		 1i18A-4e0fA:
24.29
1i18B-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 5 GLU A  70
ARG A 192
LEU A  74
ASP A 108
 None
None
RBF  A 301 ( 4.8A)
None
 1.28A 1n13B-4e0fA:
undetectable
1n13C-4e0fA:
undetectable		 1n13B-4e0fA:
23.76
1n13C-4e0fA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		6 / 11 SER A  40
CYH A  47
LEU A  48
THR A  49
THR A  75
VAL A 107
 RBF  A 301 (-3.3A)
RBF  A 301 (-3.4A)
RBF  A 301 (-4.4A)
RBF  A 301 (-3.9A)
None
RBF  A 301 (-3.9A)
 0.30A 1pkvA-4e0fA:
14.9
1pkvB-4e0fA:
15.1		 1pkvA-4e0fA:
24.29
1pkvB-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 11 SER A 142
LEU A 150
THR A 151
THR A 172
ILE A   5
 None
 0.48A 1pkvA-4e0fA:
14.9
1pkvB-4e0fA:
15.1		 1pkvA-4e0fA:
24.29
1pkvB-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 11 ILE A   5
SER A 142
LEU A 150
THR A 151
THR A 172
 None
 0.47A 1pkvA-4e0fA:
14.9
1pkvB-4e0fA:
15.1		 1pkvA-4e0fA:
24.29
1pkvB-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		6 / 11 VAL A 107
SER A  40
CYH A  47
LEU A  48
THR A  49
THR A  75
 RBF  A 301 (-3.9A)
RBF  A 301 (-3.3A)
RBF  A 301 (-3.4A)
RBF  A 301 (-4.4A)
RBF  A 301 (-3.9A)
None
 0.28A 1pkvA-4e0fA:
14.9
1pkvB-4e0fA:
15.1		 1pkvA-4e0fA:
24.29
1pkvB-4e0fA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		6 / 10 LEU A  88
ALA A  42
ILE A  41
ALA A  67
LEU A  23
PHE A  63
 None
None
None
RBF  A 301 (-4.1A)
None
None
 1.48A 1xp0A-4e0fA:
undetectable		 1xp0A-4e0fA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 8 LYS A   1
GLY A   4
ASP A 146
THR A 172
 None
 1.02A 2aouA-4e0fA:
undetectable		 2aouA-4e0fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		3 / 3 TRP A  80
GLN A 110
TRP A  68
 None
 0.92A 2vqyA-4e0fA:
undetectable		 2vqyA-4e0fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 12 SER A 149
LEU A 150
THR A 151
THR A 172
ILE A   6
 None
 0.49A 3a35A-4e0fA:
26.9		 3a35A-4e0fA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 12 SER A 149
LEU A 150
THR A 151
THR A 172
ILE A   6
 None
 0.52A 3a35B-4e0fA:
27.2		 3a35B-4e0fA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 12 SER A 149
LEU A 150
THR A 151
THR A 172
ILE A   6
 None
 0.51A 3a3bA-4e0fA:
26.2		 3a3bA-4e0fA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 8 LEU A 127
ARG A 116
SER A  44
GLY A 175
 None
 1.02A 3hcrA-4e0fA:
undetectable		 3hcrA-4e0fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 7 LEU A 127
ARG A 116
SER A  44
GLY A 175
 None
 1.04A 3hcrB-4e0fA:
undetectable		 3hcrB-4e0fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 12 GLU A 186
ILE A 187
PHE A 136
ALA A 144
ILE A 137
 None
 1.31A 3ndiA-4e0fA:
undetectable		 3ndiA-4e0fA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 4 PRO A 130
LEU A 133
ILE A 187
ARG A 192
 None
 1.06A 4f4dA-4e0fA:
undetectable		 4f4dA-4e0fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		3 / 3 ASN A 184
SER A  44
ARG A  84
 None
 0.89A 5b2qA-4e0fA:
undetectable		 5b2qA-4e0fA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		5 / 10 ALA A  67
VAL A  65
GLU A  66
ASP A  13
ILE A  26
 RBF  A 301 (-4.1A)
None
None
None
None
 1.04A 5i3cB-4e0fA:
undetectable		 5i3cB-4e0fA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA
(Brucella
abortus) 		4 / 8 ARG A  14
GLU A  27
PRO A  54
ILE A  35
 None
 1.05A 6a4iA-4e0fA:
undetectable		 6a4iA-4e0fA:
19.95