SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 GLU A 301
GLU A 300
ALA A 297
LEU A 296
LEU A 365
 None
 1.36A 1a29A-4e0tA:
undetectable		 1a29A-4e0tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 PHE A 272
VAL A 206
ALA A 131
LEU A 109
 None
None
EDO  A 604 ( 3.9A)
EDO  A 603 ( 4.4A)
 0.76A 1e7bB-4e0tA:
undetectable		 1e7bB-4e0tA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 TYR A 105
THR A 203
VAL A 151
VAL A  93
 None
EDO  A 603 ( 4.0A)
None
None
 1.03A 2qbnA-4e0tA:
undetectable		 2qbnA-4e0tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 284
ASP A 276
ASP A 210
TYR A 431
GLN A 122
 None
None
None
CL  A 606 (-4.9A)
None
 1.35A 2ya7A-4e0tA:
undetectable		 2ya7A-4e0tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 284
ASP A 276
ASP A 210
TYR A 431
GLN A 122
 None
None
None
CL  A 606 (-4.9A)
None
 1.34A 2ya7B-4e0tA:
undetectable		 2ya7B-4e0tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ARG A 284
ASP A 276
ASP A 210
TYR A 431
GLN A 122
 None
None
None
CL  A 606 (-4.9A)
None
 1.35A 2ya7D-4e0tA:
undetectable		 2ya7D-4e0tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 5 PHE A 263
ILE A 289
GLY A 235
CYH A 239
 None
 1.23A 3r0lD-4e0tA:
undetectable		 3r0lD-4e0tA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 8 VAL A 287
TYR A 366
ILE A 259
ILE A 289
 None
 0.95A 4afgD-4e0tA:
undetectable
4afgE-4e0tA:
undetectable		 4afgD-4e0tA:
20.93
4afgE-4e0tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 SER A 254
ASP A 253
ARG A 244
GLU A 260
 None
 1.25A 4eysA-4e0tA:
undetectable		 4eysA-4e0tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 PHE A 154
PHE A 155
LEU A 161
VAL A 162
VAL A  93
 None
 1.27A 4ib4A-4e0tA:
undetectable		 4ib4A-4e0tA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 VAL A 165
PHE A 155
HIS A 170
GLU A 168
 None
 1.32A 5ad9A-4e0tA:
undetectable
5ad9B-4e0tA:
undetectable		 5ad9A-4e0tA:
21.92
5ad9B-4e0tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 ILE A 434
ILE A 372
ILE A 380
PHE A 397
 None
 0.76A 5fukA-4e0tA:
undetectable
5fukB-4e0tA:
undetectable		 5fukA-4e0tA:
20.05
5fukB-4e0tA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 365
ILE A 321
GLY A 317
LYS A 362
SER A 421
 None
None
None
None
CL  A 606 (-3.4A)
 1.13A 5twjC-4e0tA:
undetectable		 5twjC-4e0tA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 ASP A 291
ARG A 298
ASP A 269
 None
 0.85A 5zvgA-4e0tA:
undetectable		 5zvgA-4e0tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 ASP A 291
ARG A 298
ASP A 269
 None
 0.89A 5zvgB-4e0tA:
undetectable		 5zvgB-4e0tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 VAL A  61
ASP A  53
HIS A  57
ARG A 106
GLY A 111
 None
 0.98A 6b0iB-4e0tA:
undetectable		 6b0iB-4e0tA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  95
VAL A 135
THR A 108
GLY A 111
GLY A 110
 None
None
EDO  A 603 (-4.6A)
None
None
 1.08A 6brdB-4e0tA:
undetectable		 6brdB-4e0tA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 TYR A  55
ASP A  53
GLN A  56
 None
 0.82A 6g1pA-4e0tA:
undetectable		 6g1pA-4e0tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 PHE A 146
ARG A 148
GLN A 204
 None
 1.16A 6g1pB-4e0tA:
undetectable		 6g1pB-4e0tA:
22.39