SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 5 GLU A 371
THR A 407
HIS A 367
LEU A 392
 None
PTR  A 405 ( 4.1A)
PTR  A 405 ( 3.5A)
PTR  A 405 ( 4.9A)
 1.38A 1d4fC-4e10A:
undetectable		 1d4fC-4e10A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A 365
LEU A 368
LEU A 304
CYH A 235
 None
 0.68A 2ab2A-4e10A:
undetectable		 2ab2A-4e10A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 5 LEU A 365
LEU A 368
LEU A 304
CYH A 235
 None
 0.69A 2ab2B-4e10A:
undetectable		 2ab2B-4e10A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		3 / 3 TYR A 369
PHE A 265
ARG A 254
 None
 0.93A 4g19D-4e10A:
undetectable		 4g19D-4e10A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 6 GLU A 337
THR A 338
LEU A 341
GLN A 322
 None
 1.16A 4qztA-4e10A:
undetectable		 4qztA-4e10A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 8 HIS A 367
ARG A 255
HIS A 394
THR A 401
 PTR  A 405 ( 3.5A)
PTR  A 405 ( 4.2A)
PTR  A 405 ( 3.9A)
DT  A 501 (-2.9A)
 1.31A 5db5A-4e10A:
undetectable
5db5B-4e10A:
undetectable		 5db5A-4e10A:
21.38
5db5B-4e10A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		3 / 3 LEU A 248
PHE A 260
ILE A 249
 None
 0.73A 5dzk1-4e10A:
undetectable
5dzkF-4e10A:
undetectable
5dzkM-4e10A:
undetectable		 5dzk1-4e10A:
1.32
5dzkF-4e10A:
20.00
5dzkM-4e10A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		5 / 12 ARG A 254
VAL A 259
LEU A 317
GLU A 258
ALA A 263
 None
 1.09A 6f6iA-4e10A:
undetectable
6f6iB-4e10A:
1.3		 6f6iA-4e10A:
10.53
6f6iB-4e10A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		5 / 11 ILE A 279
LEU A 236
GLY A 245
PHE A 265
ALA A 263
 None
 0.97A 6ieyA-4e10A:
undetectable
6ieyB-4e10A:
undetectable		 6ieyA-4e10A:
21.01
6ieyB-4e10A:
21.01