SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 8 LEU A 125
PRO A  15
VAL A 190
GLY A 189
 None
None
None
SEB  A 157 ( 3.3A)
 1.04A 1hrkA-4e14A:
3.8		 1hrkA-4e14A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		5 / 12 GLY A 159
GLY A  87
GLY A  88
VAL A  85
TYR A 255
 SEB  A 157 ( 4.0A)
EDO  A 404 (-3.6A)
SEB  A 157 ( 3.5A)
None
None
 0.88A 1n2xB-4e14A:
2.8		 1n2xB-4e14A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 8 PHE A 248
ALA A 158
HIS A 161
LEU A 125
 None
SEB  A 157 ( 3.3A)
None
None
 0.96A 1x8vA-4e14A:
undetectable		 1x8vA-4e14A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		5 / 11 LEU A 196
LEU A 193
GLY A  87
HIS A 161
LYS A 158
 None
None
EDO  A 404 (-3.6A)
None
SEB  A 157 ( 2.8A)
 1.24A 1y4lB-4e14A:
undetectable		 1y4lB-4e14A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 7 VAL A 114
LEU A  47
HIS A  43
THR A  40
 None
 1.16A 2f78A-4e14A:
undetectable		 2f78A-4e14A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 7 LEU A 193
TRP A  90
ALA A 158
GLY A 189
 None
None
SEB  A 157 ( 3.3A)
SEB  A 157 ( 3.3A)
 0.91A 2wq5A-4e14A:
undetectable		 2wq5A-4e14A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 5 TYR A  13
VAL A 190
ASP A 192
SER A 219
 None
 1.30A 2x45A-4e14A:
undetectable		 2x45A-4e14A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 6 HIS A 134
THR A 130
PHE A 132
GLN A 165
 None
 1.18A 3bgdA-4e14A:
undetectable		 3bgdA-4e14A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		3 / 3 TYR A 225
TYR A 255
GLU A 216
 None
 0.87A 3pfgA-4e14A:
undetectable		 3pfgA-4e14A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 6 PHE A 135
PHE A 132
PHE A 153
ALA A 154
 None
 1.14A 3t3sB-4e14A:
undetectable		 3t3sB-4e14A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		3 / 3 GLN A 251
PHE A 248
TYR A  13
 None
 0.86A 3ucjB-4e14A:
1.7		 3ucjB-4e14A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 8 LEU A 167
VAL A 230
LEU A 259
TYR A 225
 None
 1.10A 3v81A-4e14A:
undetectable		 3v81A-4e14A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 8 LEU A 259
TYR A 191
LEU A 167
TYR A 264
 None
 0.96A 3v81A-4e14A:
undetectable		 3v81A-4e14A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 8 ARG A 194
LEU A 193
TRP A 223
TYR A 255
 None
 1.13A 3wipF-4e14A:
undetectable
3wipJ-4e14A:
undetectable		 3wipF-4e14A:
22.73
3wipJ-4e14A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		4 / 7 VAL A 172
ILE A 173
LEU A  81
LEU A 151
 None
EDO  A 402 (-4.1A)
None
None
 0.89A 4l1wA-4e14A:
undetectable		 4l1wA-4e14A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4e14 KYNURENINE
FORMAMIDASE
(Drosophila
melanogaster) 		5 / 12 ALA A 241
GLY A 155
ALA A 154
LEU A 105
LEU A 294
 None
 1.00A 5xxiA-4e14A:
undetectable		 5xxiA-4e14A:
21.35