SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 THR A 186
VAL A 226
GLY A 180
ALA A 155
ILE A 151
 None
 0.95A 1bx4A-4e16A:
undetectable		 1bx4A-4e16A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		4 / 8 VAL A 226
THR A 205
TYR A 182
LEU A 177
 None
 0.96A 1z2bB-4e16A:
undetectable		 1z2bB-4e16A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 9 THR A 186
LEU A 206
GLU A 179
ALA A 155
TYR A 154
 None
 1.31A 2azqA-4e16A:
undetectable		 2azqA-4e16A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 VAL A 190
GLY A 116
ALA A 117
SER A 120
LEU A 121
 None
 0.96A 3hs6A-4e16A:
undetectable		 3hs6A-4e16A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		4 / 8 LEU A 230
VAL A 127
TYR A 125
LEU A 121
 None
 1.10A 3v81A-4e16A:
undetectable		 3v81A-4e16A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 VAL A  38
ILE A  87
GLY A 110
ILE A  17
LEU A  80
 None
 0.94A 4iv0A-4e16A:
undetectable		 4iv0A-4e16A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 VAL A  38
ILE A  87
GLY A 110
ILE A  17
LEU A  80
 None
 0.90A 4mwzB-4e16A:
undetectable		 4mwzB-4e16A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 ALA A   9
ILE A  52
GLY A  35
ALA A  34
VAL A  31
 None
 1.11A 4nkvC-4e16A:
undetectable		 4nkvC-4e16A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 LEU A  43
ALA A   9
ILE A  52
GLY A  35
ALA A  34
 None
 1.10A 4nkvC-4e16A:
undetectable		 4nkvC-4e16A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 LEU A  43
ALA A   9
ILE A  52
GLY A  35
ALA A  34
 None
 1.10A 4nkvD-4e16A:
undetectable		 4nkvD-4e16A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		4 / 8 LEU A 230
VAL A 127
TYR A 125
LEU A 121
 None
 1.07A 4pwdC-4e16A:
undetectable		 4pwdC-4e16A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		5 / 12 VAL A 127
GLY A 227
TYR A 125
SER A 131
ILE A 188
 None
 1.41A 4xueB-4e16A:
undetectable		 4xueB-4e16A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		3 / 3 THR A 195
THR A 221
LEU A  37
 None
 0.69A 5m66D-4e16A:
undetectable		 5m66D-4e16A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		4 / 8 SER A  86
THR A  18
ILE A  17
ALA A   9
 None
 0.80A 5te8B-4e16A:
undetectable		 5te8B-4e16A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE
(Clostridioides
difficile) 		3 / 3 GLY A 180
VAL A 226
MET A 161
 None
 0.62A 5ycpA-4e16A:
undetectable		 5ycpA-4e16A:
14.29