SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 CYH A 112
ASP A  99
VAL A 105
GLY A 103
 None
 1.18A 1ekjC-4e1eA:
undetectable
1ekjD-4e1eA:
undetectable		 1ekjC-4e1eA:
20.27
1ekjD-4e1eA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLU A  88
ALA A  59
PHE A 148
PHE A 156
PHE A 143
 None
 1.24A 1nw3A-4e1eA:
undetectable		 1nw3A-4e1eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 VAL A  58
VAL A 235
LEU A 234
LEU A 221
 None
 0.89A 1pthB-4e1eA:
undetectable		 1pthB-4e1eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.52A 1rqjA-4e1eA:
30.4		 1rqjA-4e1eA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.51A 1rqjB-4e1eA:
30.4		 1rqjB-4e1eA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 MET A 101
ASP A 102
ASP A  99
LYS A 264
 None
MG  A 403 (-2.4A)
None
0MW  A 404 ( 3.0A)
 1.16A 1t03A-4e1eA:
undetectable		 1t03A-4e1eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 TYR A 324
THR A 208
THR A 209
VAL A 328
 None
IPE  A 405 ( 4.6A)
None
None
 1.19A 1tv8A-4e1eA:
undetectable		 1tv8A-4e1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.05A 1v55C-4e1eA:
1.7
1v55J-4e1eA:
undetectable		 1v55C-4e1eA:
20.44
1v55J-4e1eA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 1yhlA-4e1eA:
57.0		 1yhlA-4e1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
0MW  A 404 (-2.7A)
None
None
0MW  A 404 ( 3.0A)
 1.44A 1yq7A-4e1eA:
43.6		 1yq7A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.49A 1yq7A-4e1eA:
43.6		 1yq7A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.19A 1yv5A-4e1eA:
44.0		 1yv5A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.40A 1yv5A-4e1eA:
44.0		 1yv5A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 1zw5A-4e1eA:
45.0		 1zw5A-4e1eA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.17A 1zw5A-4e1eA:
45.0		 1zw5A-4e1eA:
37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.44A 2e91A-4e1eA:
24.6		 2e91A-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
THR A 163
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
None
 1.50A 2e91A-4e1eA:
24.6		 2e91A-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A  98
ASP A 102
GLN A 167
LYS A 207
LYS A 273
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
MG  A 403 ( 4.5A)
 1.42A 2e91A-4e1eA:
24.6		 2e91A-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
ASP A 254
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
MG  A 401 ( 4.5A)
 1.38A 2e91B-4e1eA:
23.7		 2e91B-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.52A 2e91B-4e1eA:
23.7		 2e91B-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.07A 2eijC-4e1eA:
1.7
2eijJ-4e1eA:
undetectable		 2eijC-4e1eA:
20.44
2eijJ-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.04A 2eijP-4e1eA:
1.7
2eijW-4e1eA:
undetectable		 2eijP-4e1eA:
20.44
2eijW-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.04A 2eimC-4e1eA:
2.8
2eimJ-4e1eA:
undetectable		 2eimC-4e1eA:
20.44
2eimJ-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.13A 2einP-4e1eA:
2.2
2einW-4e1eA:
undetectable		 2einP-4e1eA:
20.44
2einW-4e1eA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.23A 2f89F-4e1eA:
45.5		 2f89F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.18A 2f8cF-4e1eA:
44.6		 2f8cF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
0MW  A 404 (-2.7A)
None
None
0MW  A 404 ( 3.0A)
 1.42A 2f8cF-4e1eA:
44.6		 2f8cF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.37A 2f8cF-4e1eA:
44.6		 2f8cF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.12A 2f8zF-4e1eA:
45.3		 2f8zF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.41A 2f8zF-4e1eA:
45.3		 2f8zF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 2f94F-4e1eA:
44.3		 2f94F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 2f9kF-4e1eA:
44.5		 2f9kF-4e1eA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 TYR A 324
THR A 208
THR A 209
VAL A 328
 None
IPE  A 405 ( 4.6A)
None
None
 1.18A 2fb2A-4e1eA:
undetectable		 2fb2A-4e1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 PRO A 302
ALA A 303
ASP A 102
ASP A 299
 None
None
MG  A 403 (-2.4A)
None
 1.16A 2nyuB-4e1eA:
undetectable		 2nyuB-4e1eA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.55A 2o1oA-4e1eA:
37.1		 2o1oA-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.59A 2o1oB-4e1eA:
37.4		 2o1oB-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 273
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
MG  A 403 ( 4.5A)
 1.15A 2o1oB-4e1eA:
37.4		 2o1oB-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A  98
ARG A 107
GLN A 167
LYS A 207
ASP A 268
 MG  A 403 (-2.5A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
MG  A 401 ( 3.8A)
 1.45A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 251
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
None
 0.69A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 10 ASP A  98
ASP A 102
GLN A 167
LYS A 207
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 1.47A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 LEU A  95
ASP A  98
ARG A 107
LYS A 207
ASP A 268
 None
MG  A 403 (-2.5A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
MG  A 401 ( 3.8A)
 1.40A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 251
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
None
 0.72A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.66A 2q58B-4e1eA:
36.8		 2q58B-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A  98
ASP A 102
GLN A 167
LYS A 207
LYS A 273
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
MG  A 403 ( 4.5A)
 1.27A 2q58B-4e1eA:
36.8		 2q58B-4e1eA:
27.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 2qisA-4e1eA:
44.2		 2qisA-4e1eA:
36.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A 234
ILE A 336
ALA A 347
ARG A  51
LEU A 217
 None
None
None
IPE  A 405 (-2.5A)
None
 1.20A 2v0mA-4e1eA:
undetectable		 2v0mA-4e1eA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.98A 3ag2P-4e1eA:
1.7
3ag2W-4e1eA:
undetectable		 3ag2P-4e1eA:
20.44
3ag2W-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.04A 3asnP-4e1eA:
2.8
3asnW-4e1eA:
undetectable		 3asnP-4e1eA:
20.44
3asnW-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.01A 3asoP-4e1eA:
1.8
3asoW-4e1eA:
undetectable		 3asoP-4e1eA:
20.44
3asoW-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.57A 3ez3A-4e1eA:
45.1		 3ez3A-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 3ez3B-4e1eA:
44.3		 3ez3B-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.56A 3ez3C-4e1eA:
45.1		 3ez3C-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.48A 3ez3D-4e1eA:
44.0		 3ez3D-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.50A 3ibaA-4e1eA:
57.0		 3ibaA-4e1eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 PHE A  50
TYR A 245
VAL A 218
LEU A 215
 None
 1.48A 3keeD-4e1eA:
undetectable		 3keeD-4e1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 220
LEU A 155
LEU A 217
GLU A 225
ALA A 227
 None
 0.98A 3kkzA-4e1eA:
undetectable		 3kkzA-4e1eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.58A 3ldwA-4e1eA:
45.0		 3ldwA-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.47A 3ldwB-4e1eA:
44.4		 3ldwB-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.56A 3ldwC-4e1eA:
45.0		 3ldwC-4e1eA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.47A 3ldwD-4e1eA:
44.1		 3ldwD-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
0MW  A 404 (-2.7A)
None
None
0MW  A 404 ( 3.0A)
 1.49A 3n45F-4e1eA:
44.7		 3n45F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 3n45F-4e1eA:
44.7		 3n45F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.45A 3n46F-4e1eA:
44.4		 3n46F-4e1eA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  95
PHE A  89
GLY A  47
GLU A  88
PHE A   7
 None
None
IPE  A 405 (-3.6A)
None
None
 1.26A 3tbgC-4e1eA:
undetectable		 3tbgC-4e1eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 264
ARG A  51
LEU A  95
 0MW  A 404 ( 3.0A)
IPE  A 405 (-2.5A)
None
 1.40A 3v4tE-4e1eA:
undetectable		 3v4tE-4e1eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.99A 3wg7C-4e1eA:
1.7
3wg7J-4e1eA:
undetectable		 3wg7C-4e1eA:
20.44
3wg7J-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.99A 3wg7P-4e1eA:
2.8
3wg7W-4e1eA:
undetectable		 3wg7P-4e1eA:
20.44
3wg7W-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.94A 3x2qP-4e1eA:
1.7
3x2qW-4e1eA:
undetectable		 3x2qP-4e1eA:
20.44
3x2qW-4e1eA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.44A 4kfaA-4e1eA:
43.8		 4kfaA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.36A 4kpdA-4e1eA:
44.9		 4kpdA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.32A 4kpjA-4e1eA:
43.8		 4kpjA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 4kq5A-4e1eA:
44.2		 4kq5A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 4kqsA-4e1eA:
44.6		 4kqsA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.22A 4n9uA-4e1eA:
43.6		 4n9uA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.49A 4n9uA-4e1eA:
43.6		 4n9uA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 208
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
IPE  A 405 ( 4.6A)
 1.30A 4n9uA-4e1eA:
43.6		 4n9uA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 4ng6A-4e1eA:
45.1		 4ng6A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.29A 4nkeA-4e1eA:
44.0		 4nkeA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.55A 4nkeA-4e1eA:
44.0		 4nkeA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.35A 4nkfA-4e1eA:
43.8		 4nkfA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.36A 4nuaA-4e1eA:
43.9		 4nuaA-4e1eA:
36.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.60A 4nuaA-4e1eA:
43.9		 4nuaA-4e1eA:
36.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.29A 4oguA-4e1eA:
43.8		 4oguA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 4p0vA-4e1eA:
45.3		 4p0vA-4e1eA:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
0MW  A 404 (-2.7A)
None
None
0MW  A 404 ( 3.0A)
 1.46A 4p0wA-4e1eA:
45.3		 4p0wA-4e1eA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.39A 4p0wA-4e1eA:
45.3		 4p0wA-4e1eA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A 102
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 1.19A 4q23A-4e1eA:
43.8		 4q23A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 4q23A-4e1eA:
43.8		 4q23A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.45A 4rxdA-4e1eA:
53.3		 4rxdA-4e1eA:
69.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 4rxdB-4e1eA:
53.8		 4rxdB-4e1eA:
69.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.44A 4rxdC-4e1eA:
53.8		 4rxdC-4e1eA:
69.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 8 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
 0.57A 4umjA-4e1eA:
23.4		 4umjA-4e1eA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
 0.45A 4umjB-4e1eA:
23.5		 4umjB-4e1eA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
 1.18A 4umjB-4e1eA:
23.5		 4umjB-4e1eA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		3 / 3 ASP A  99
ARG A 360
ARG A  51
 None
IPE  A 405 ( 4.7A)
IPE  A 405 (-2.5A)
 0.87A 4x5iA-4e1eA:
undetectable		 4x5iA-4e1eA:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 5cg5A-4e1eA:
44.4		 5cg5A-4e1eA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.37A 5cg6A-4e1eA:
45.1		 5cg6A-4e1eA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.61A 5eroA-4e1eA:
27.0		 5eroA-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 LEU A  95
ASP A  98
LYS A 207
GLN A 247
LYS A 264
 None
MG  A 403 (-2.5A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
0MW  A 404 ( 3.0A)
 1.32A 5eroA-4e1eA:
27.0		 5eroA-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 9 ASP A  98
ARG A 107
LYS A 207
GLN A 247
ASP A 251
LYS A 264
 MG  A 403 (-2.5A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
None
0MW  A 404 ( 3.0A)
 1.22A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 0.58A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 1.48A 5eroB-4e1eA:
26.8		 5eroB-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 ASP A  98
ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.5A)
None
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 0.63A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 10 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 251
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
None
0MW  A 404 ( 3.0A)
 1.00A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 1.45A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 10 ASP A 102
ASP A  99
ARG A 107
GLN A 247
ASP A 250
ASP A 251
 MG  A 403 (-2.4A)
None
0MW  A 404 (-2.7A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
None
 1.37A 5eroC-4e1eA:
27.0		 5eroC-4e1eA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 152
PHE A 143
PHE A 148
ALA A  59
LEU A  63
 None
 1.11A 5iepA-4e1eA:
0.6		 5iepA-4e1eA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.03A 5iy5P-4e1eA:
2.2
5iy5W-4e1eA:
undetectable		 5iy5P-4e1eA:
20.44
5iy5W-4e1eA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 405 ( 4.6A)
None
None
 0.93A 5nzxA-4e1eA:
undetectable		 5nzxA-4e1eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 405 ( 4.6A)
None
None
 0.92A 5nzyA-4e1eA:
undetectable		 5nzyA-4e1eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.14A 5w97C-4e1eA:
2.7
5w97J-4e1eA:
undetectable		 5w97C-4e1eA:
20.44
5w97J-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.17A 5x1fC-4e1eA:
2.8
5x1fJ-4e1eA:
undetectable		 5x1fC-4e1eA:
20.44
5x1fJ-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.09A 5xdxC-4e1eA:
undetectable
5xdxJ-4e1eA:
undetectable		 5xdxC-4e1eA:
20.44
5xdxJ-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.06A 5xdxP-4e1eA:
2.3
5xdxW-4e1eA:
undetectable		 5xdxP-4e1eA:
20.44
5xdxW-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
 0.97A 6g31A-4e1eA:
25.5		 6g31A-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.71A 6g31B-4e1eA:
25.4		 6g31B-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 5 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
 1.14A 6g31C-4e1eA:
25.7		 6g31C-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.58A 6g31D-4e1eA:
24.9		 6g31D-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 LEU A  95
ASP A  98
ASP A 102
ARG A 107
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
 0.36A 6g31E-4e1eA:
19.3		 6g31E-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 5 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.70A 6g31F-4e1eA:
25.5		 6g31F-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
 0.54A 6g31G-4e1eA:
24.5		 6g31G-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ASP A  98
ASP A 102
GLN A 167
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.57A 6g31H-4e1eA:
24.4		 6g31H-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ASP A  98
ASP A 102
GLN A 167
LYS A 273
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
MG  A 403 ( 4.5A)
 1.38A 6g31H-4e1eA:
24.4		 6g31H-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 ASP A  98
ASP A 102
LYS A 207
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
 0.88A 6g31I-4e1eA:
24.5		 6g31I-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.90A 6g31J-4e1eA:
25.8		 6g31J-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 ASP A  98
ASP A 102
ARG A 107
GLN A 167
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
 0.43A 6g31K-4e1eA:
23.6		 6g31K-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		6 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
LYS A 273
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
MG  A 403 ( 4.5A)
 1.18A 6g31L-4e1eA:
25.2		 6g31L-4e1eA:
11.98