SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 12 SER A 326
GLY A 325
LEU A 307
GLY A 373
PHE A 158
 None
 1.10A 1fduA-4e1jA:
undetectable		 1fduA-4e1jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 401
VAL A 366
TRP A 509
 None
 1.00A 1gmkC-4e1jA:
undetectable
1gmkD-4e1jA:
undetectable		 1gmkC-4e1jA:
2.80
1gmkD-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 9 ALA A 467
GLY A 262
ILE A 101
ILE A  96
ILE A  28
 None
 0.93A 1hshB-4e1jA:
undetectable		 1hshB-4e1jA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.74A 1jo3A-4e1jA:
undetectable		 1jo3A-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.74A 1jo3B-4e1jA:
undetectable		 1jo3B-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.94A 1jo4A-4e1jA:
undetectable		 1jo4A-4e1jA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.94A 1jo4B-4e1jA:
undetectable		 1jo4B-4e1jA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.91A 1ng8A-4e1jA:
undetectable		 1ng8A-4e1jA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.91A 1ng8B-4e1jA:
undetectable		 1ng8B-4e1jA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.89A 1nrmA-4e1jA:
undetectable		 1nrmA-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.89A 1nrmB-4e1jA:
undetectable		 1nrmB-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.92A 1nruA-4e1jA:
undetectable		 1nruA-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.92A 1nruB-4e1jA:
undetectable		 1nruB-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.78A 1nt6A-4e1jA:
undetectable		 1nt6A-4e1jA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 122
VAL A 110
TRP A 111
 None
 0.77A 1nt6B-4e1jA:
undetectable		 1nt6B-4e1jA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		3 / 3 ASN A 215
TYR A 321
SER A 209
 None
 0.94A 2gvcB-4e1jA:
undetectable		 2gvcB-4e1jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 ASN A 103
GLY A 265
THR A 206
SER A 159
 None
 1.09A 2o5yH-4e1jA:
undetectable
2o5yL-4e1jA:
undetectable		 2o5yH-4e1jA:
18.53
2o5yL-4e1jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 SER A 209
LEU A 293
ILE A 311
GLY A 325
 None
 0.92A 2v0mC-4e1jA:
undetectable		 2v0mC-4e1jA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 366
HIS A 376
THR A 516
LEU A 517
 None
 1.03A 3arrA-4e1jA:
undetectable		 3arrA-4e1jA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 182
ALA A 173
LEU A 166
ASN A 169
VAL A 231
 None
 1.29A 3e22B-4e1jA:
undetectable		 3e22B-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 182
ALA A 173
LEU A 166
ASN A 169
VAL A 231
 None
 1.29A 3e22D-4e1jA:
undetectable		 3e22D-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 5 ASP A 204
ARG A 210
VAL A 108
THR A  35
 None
None
None
GOL  A 601 ( 4.9A)
 1.05A 3eigA-4e1jA:
undetectable		 3eigA-4e1jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 270
ASP A 432
SER A 326
ILE A 327
THR A 461
 None
 1.20A 3qgtA-4e1jA:
undetectable		 3qgtA-4e1jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 5 PHE A 277
ALA A 312
THR A 206
LEU A 315
 None
 1.18A 3t3zC-4e1jA:
undetectable		 3t3zC-4e1jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 5 ASP A 222
THR A 226
LEU A 225
LYS A 149
 None
 1.29A 4a3pA-4e1jA:
undetectable		 4a3pA-4e1jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 9 GLY A 373
ASP A 378
ALA A 381
GLY A 371
VAL A 366
 None
 1.25A 4c5lB-4e1jA:
undetectable		 4c5lB-4e1jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 373
ASP A 378
ALA A 381
GLY A 371
VAL A 366
 None
 1.27A 4c5nB-4e1jA:
undetectable		 4c5nB-4e1jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 191
PHE A  57
VAL A  78
THR A 288
GLY A 287
 None
 1.17A 4hvcB-4e1jA:
undetectable		 4hvcB-4e1jA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 489
GLN A 274
GLY A 273
THR A 461
 None
 1.00A 4k87A-4e1jA:
undetectable		 4k87A-4e1jA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 4 THR A 310
GLY A 265
ASP A 266
SER A 209
 None
None
GOL  A 601 (-2.7A)
None
 1.14A 4rfqA-4e1jA:
undetectable		 4rfqA-4e1jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 195
THR A  38
ALA A  40
LEU A  29
 None
 0.79A 4ubsA-4e1jA:
undetectable		 4ubsA-4e1jA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  29
THR A  81
ALA A  85
ALA A  50
ILE A  86
 None
 1.04A 4x1iD-4e1jA:
undetectable		 4x1iD-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  29
THR A  81
ALA A  85
ALA A  50
ILE A  86
 None
 1.04A 4x1yD-4e1jA:
undetectable		 4x1yD-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 7 LEU A 213
LEU A 236
THR A 189
THR A 186
THR A 211
 None
 1.32A 4z90A-4e1jA:
undetectable
4z90B-4e1jA:
undetectable
4z90C-4e1jA:
undetectable
4z90D-4e1jA:
undetectable
4z90E-4e1jA:
undetectable		 4z90A-4e1jA:
19.58
4z90B-4e1jA:
19.58
4z90C-4e1jA:
19.58
4z90D-4e1jA:
19.58
4z90E-4e1jA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 293
ALA A 292
LEU A 308
ARG A 210
LEU A 413
 None
 1.47A 5hyrB-4e1jA:
undetectable		 5hyrB-4e1jA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A  28
GLY A 100
ILE A 101
VAL A 248
ILE A 258
 None
 1.23A 5kr2B-4e1jA:
undetectable		 5kr2B-4e1jA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A 185
ALA A 122
PHE A 184
ASN A 207
 None
 0.99A 5mvsA-4e1jA:
undetectable		 5mvsA-4e1jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 8 GLY A 185
ALA A 122
PHE A 184
ASN A 207
 None
 0.98A 5mvsB-4e1jA:
undetectable		 5mvsB-4e1jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 8 TYR A  27
GLN A  21
VAL A  42
GLY A  51
 None
NA  A 602 ( 4.5A)
None
None
 0.98A 5nzyA-4e1jA:
undetectable		 5nzyA-4e1jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		5 / 10 GLN A 408
GLY A 508
VAL A 366
LEU A 365
ALA A 400
 None
 0.95A 5o96E-4e1jA:
undetectable
5o96F-4e1jA:
undetectable		 5o96E-4e1jA:
18.33
5o96F-4e1jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A 327
LEU A 412
MET A 416
LEU A 413
 None
 1.04A 5u4sB-4e1jA:
undetectable		 5u4sB-4e1jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4e1j GLYCEROL KINASE
(Sinorhizobium
meliloti) 		4 / 7 ILE A 187
GLN A  33
GLU A  73
HIS A  69
 None
 1.20A 6j20A-4e1jA:
undetectable		 6j20A-4e1jA:
21.68