SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PHE A 133
SER A 140
PHE A 299
ALA A 124
 None
 1.17A 1fxvA-4e1oA:
undetectable
1fxvB-4e1oA:
undetectable		 1fxvA-4e1oA:
20.28
1fxvB-4e1oA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 9 TRP A  72
TYR A  80
HIS A 194
THR A 248
LYS A 305
 None
PVH  A1001 (-4.9A)
PLP  A1000 ( 3.3A)
PLP  A1000 (-3.1A)
PLP  A1000 ( 3.1A)
 0.38A 1js3A-4e1oA:
61.3
1js3B-4e1oA:
61.3		 1js3A-4e1oA:
50.72
1js3B-4e1oA:
50.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 9 TRP A  72
TYR A  80
HIS A 194
THR A 248
LYS A 305
 None
PVH  A1001 (-4.9A)
PLP  A1000 ( 3.3A)
PLP  A1000 (-3.1A)
PLP  A1000 ( 3.1A)
 0.39A 1js3A-4e1oA:
61.3
1js3B-4e1oA:
61.3		 1js3A-4e1oA:
50.72
1js3B-4e1oA:
50.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 PHE A 398
ALA A 471
ILE A 446
ILE A 427
 None
 0.80A 1oniD-4e1oA:
undetectable
1oniF-4e1oA:
undetectable		 1oniD-4e1oA:
15.77
1oniF-4e1oA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.14A 1p7lC-4e1oA:
undetectable		 1p7lC-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.13A 1p7lD-4e1oA:
undetectable		 1p7lD-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.15A 1rg9A-4e1oA:
undetectable		 1rg9A-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.13A 1rg9B-4e1oA:
undetectable		 1rg9B-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.13A 1rg9C-4e1oA:
undetectable		 1rg9C-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.12A 1rg9D-4e1oA:
undetectable		 1rg9D-4e1oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 419
ALA A 471
ILE A 467
ASN A 422
SER A 476
 None
 1.22A 2ejtA-4e1oA:
2.9		 2ejtA-4e1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.24A 2p02A-4e1oA:
undetectable		 2p02A-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 PHE A 301
PHE A 299
PHE A 133
GLY A 128
 None
 0.96A 2qwxA-4e1oA:
undetectable
2qwxB-4e1oA:
undetectable		 2qwxA-4e1oA:
18.96
2qwxB-4e1oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A 380
ILE A 460
ASP A 459
ARG A  26
 None
 1.10A 2v57A-4e1oA:
undetectable		 2v57A-4e1oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A 380
ILE A 460
ASP A 459
ARG A  26
 None
 1.10A 2v57C-4e1oA:
undetectable		 2v57C-4e1oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 LEU A 374
MET A 307
MET A 384
 None
 0.97A 2vavF-4e1oA:
2.2		 2vavF-4e1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 290
PHE A 289
PHE A 281
PHE A 133
 None
 0.98A 3ag2C-4e1oA:
undetectable		 3ag2C-4e1oA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 LEU A 290
PHE A 289
PHE A 281
PHE A 133
 None
 0.94A 3ag4C-4e1oA:
undetectable
3ag4J-4e1oA:
undetectable		 3ag4C-4e1oA:
19.80
3ag4J-4e1oA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 ARG A 432
GLU A  27
ASP A 459
ARG A 462
 None
 1.23A 4kcnA-4e1oA:
undetectable		 4kcnA-4e1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.14A 4kttA-4e1oA:
undetectable		 4kttA-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.19A 4ndnC-4e1oA:
undetectable		 4ndnC-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.10A 4odjA-4e1oA:
undetectable		 4odjA-4e1oA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 PHE A 301
PHE A 299
PHE A 133
GLY A 128
 None
 0.95A 4qogA-4e1oA:
undetectable
4qogB-4e1oA:
undetectable		 4qogA-4e1oA:
18.96
4qogB-4e1oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 PHE A 301
PHE A 299
PHE A 133
GLY A 128
 None
 1.01A 4qoiA-4e1oA:
undetectable
4qoiB-4e1oA:
undetectable		 4qoiA-4e1oA:
18.96
4qoiB-4e1oA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.20A 5a1iA-4e1oA:
undetectable		 5a1iA-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.20A 5a1iA-4e1oA:
undetectable		 5a1iA-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 4 LEU A 362
MET A 120
VAL A 119
ASN A 118
 None
 1.30A 5b8iB-4e1oA:
undetectable		 5b8iB-4e1oA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 VAL A 119
SER A 359
TRP A 363
 None
 0.80A 5jwaA-4e1oA:
undetectable		 5jwaA-4e1oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.10A 5t8sB-4e1oA:
undetectable		 5t8sB-4e1oA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 PHE A 448
VAL A  70
PRO A  75
VAL A 450
 None
 1.35A 6ekzA-4e1oA:
undetectable		 6ekzA-4e1oA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.16A 6fbnB-4e1oA:
undetectable		 6fbnB-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.16A 6fboA-4e1oA:
undetectable		 6fboA-4e1oA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.20A 6fcbA-4e1oA:
undetectable		 6fcbA-4e1oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.18A 6fcdA-4e1oA:
undetectable		 6fcdA-4e1oA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.19A 6g6rA-4e1oA:
undetectable		 6g6rA-4e1oA:
22.42