SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 5 ILE A 385
ARG A 229
ASP A 170
ASN A 349
 None
 0.99A 1kiaD-4e1tA:
0.7		 1kiaD-4e1tA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 5 ARG A 190
LEU A 378
ASP A 170
LEU A 169
 None
 1.23A 1n13B-4e1tA:
undetectable
1n13C-4e1tA:
undetectable		 1n13B-4e1tA:
16.87
1n13C-4e1tA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		5 / 10 TYR A 389
ASP A 259
LEU A 307
VAL A 386
ILE A 385
 None
 1.49A 1q6iB-4e1tA:
undetectable		 1q6iB-4e1tA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 7 LEU A 301
PHE A 302
GLU A 341
ASN A 384
 None
 1.05A 5n5dA-4e1tA:
undetectable		 5n5dA-4e1tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 6 TYR A 294
GLU A 297
GLY A 270
GLY A 271
 None
None
None
OLC  A 412 ( 4.0A)
 0.96A 5x7pB-4e1tA:
undetectable		 5x7pB-4e1tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 5 VAL A 386
ARG A 229
GLY A 270
TYR A 248
 None
 0.95A 5x80A-4e1tA:
undetectable
5x80B-4e1tA:
undetectable		 5x80A-4e1tA:
19.03
5x80B-4e1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 7 VAL A 386
ARG A 229
GLY A 270
TYR A 248
 None
 0.97A 5x80C-4e1tA:
undetectable
5x80D-4e1tA:
undetectable		 5x80C-4e1tA:
19.03
5x80D-4e1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 5 GLY A 270
TYR A 248
VAL A 386
ARG A 229
 None
 0.91A 5x80C-4e1tA:
undetectable
5x80D-4e1tA:
undetectable		 5x80C-4e1tA:
19.03
5x80D-4e1tA:
19.03