SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		5 / 12 LEU A  51
PHE A  25
ILE A  20
PHE A  74
TYR A  98
 None
 1.42A 1osvB-4e2aA:
undetectable		 1osvB-4e2aA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		4 / 4 ASN A  78
SER A 126
LEU A 125
THR A  84
 None
 1.28A 4an2A-4e2aA:
undetectable		 4an2A-4e2aA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		4 / 5 ASP A 165
VAL A 132
TRP A 166
GLU A 134
 None
 1.48A 4qzuA-4e2aA:
0.0
4qzuD-4e2aA:
0.0		 4qzuA-4e2aA:
19.71
4qzuD-4e2aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		5 / 9 GLU A 118
GLY A 124
SER A 123
GLN A 121
LEU A 172
 None
 1.34A 5ksnB-4e2aA:
undetectable		 5ksnB-4e2aA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		4 / 8 LEU A 130
PHE A 113
GLU A 114
LEU A 142
 None
 0.92A 5mzjA-4e2aA:
undetectable		 5mzjA-4e2aA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 4e2a PUTATIVE
ACETYLTRANSFERASE
(Streptococcus
mutans) 		5 / 9 GLU A 118
GLY A 124
SER A 123
GLN A 121
LEU A 172
 None
 1.34A 5syiB-4e2aA:
undetectable		 5syiB-4e2aA:
14.97