SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 11 LEU A 579
LEU A 577
ALA A 382
MET A 372
LEU A 369
 None
 1.42A 1kt6A-4e2iA:
undetectable		 1kt6A-4e2iA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		3 / 3 ASP A 429
GLU A 473
TYR A 531
 None
 0.65A 1wsvA-4e2iA:
undetectable		 1wsvA-4e2iA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 6 LEU A 288
PHE A 327
ILE A 336
ALA A 340
 None
 0.93A 2j5mA-4e2iA:
undetectable		 2j5mA-4e2iA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4e2i DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		5 / 12 ILE 2  24
ILE 2  46
LEU 2  45
CYH 2  49
VAL 2  55
 None
 1.20A 2qo5A-4e2i2:
undetectable		 2qo5A-4e2i2:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 12 GLY A 390
ALA A 574
LEU A 577
VAL A 611
PHE A 607
 None
 1.10A 2zulA-4e2iA:
undetectable		 2zulA-4e2iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 7 GLY A 445
LYS A 446
ASP A 466
ARG A 349
 None
 1.28A 3arrA-4e2iA:
undetectable		 3arrA-4e2iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 7 GLY A 445
LYS A 446
ASP A 466
ARG A 349
 None
 1.27A 3aruA-4e2iA:
undetectable		 3aruA-4e2iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 12 GLY A 390
ALA A 574
LEU A 577
VAL A 611
PHE A 607
 None
 1.08A 3dmhA-4e2iA:
undetectable		 3dmhA-4e2iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		3 / 3 ASP A 283
LEU A 345
GLN A 519
 None
 0.75A 3g4lA-4e2iA:
undetectable		 3g4lA-4e2iA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 4 LEU A 461
GLY A 462
LEU A 509
GLU A 510
 None
 0.92A 3tgvB-4e2iA:
undetectable		 3tgvB-4e2iA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 12 CYH A 337
TYR A 292
GLN A 296
VAL A 268
LEU A 272
 None
 1.45A 4k38B-4e2iA:
undetectable		 4k38B-4e2iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 5 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.09A 4olaA-4e2iA:
undetectable		 4olaA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 6 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.24A 4z4cA-4e2iA:
undetectable		 4z4cA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 5 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.23A 4z4hA-4e2iA:
undetectable		 4z4hA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4e2i DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens) 		4 / 7 PHE 2  15
ILE 2  46
LEU 2  57
GLY 2  56
 None
 0.85A 5h3aB-4e2i2:
undetectable		 5h3aB-4e2i2:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 5 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.09A 5js1A-4e2iA:
undetectable		 5js1A-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 11 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
 None
 1.01A 5x6yA-4e2iA:
3.1		 5x6yA-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 10 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
 None
 0.92A 5x6yB-4e2iA:
2.9		 5x6yB-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		5 / 11 VAL A 625
GLY A 624
ALA A 389
SER A 560
LEU A 563
 None
 1.05A 5x6yC-4e2iA:
2.9		 5x6yC-4e2iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		4 / 8 ILE A 384
LEU A 577
LEU A 394
ALA A 392
 None
 0.69A 5y7pE-4e2iA:
undetectable		 5y7pE-4e2iA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4e2i LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		3 / 3 ARG A 548
LYS A 550
ARG A 559
 None
 1.36A 6c06D-4e2iA:
undetectable		 6c06D-4e2iA:
undetectable