SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 LEU A 387
ALA A  37
THR A  86
ARG A 395
LEU A 305
 None
 1.26A 1cbrA-4e2oA:
undetectable		 1cbrA-4e2oA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 LEU A 387
ALA A  37
THR A  86
ARG A 395
LEU A 305
 None
 1.26A 1cbrB-4e2oA:
undetectable		 1cbrB-4e2oA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		8 / 12 HIS A 102
TYR A 104
LEU A 184
ASP A 217
GLU A 246
ASP A 314
ASP A 362
ARG A 366
 GLC  A 504 ( 3.7A)
ACI  A 505 (-4.1A)
GLC  A 504 (-4.8A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-2.8A)
GLC  A 504 (-2.8A)
GLC  A 504 (-2.6A)
 1.00A 1dedA-4e2oA:
43.3		 1dedA-4e2oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		8 / 12 HIS A 102
TYR A 104
LEU A 184
ASP A 217
HIS A 313
ASP A 314
ASP A 362
ARG A 366
 GLC  A 504 ( 3.7A)
ACI  A 505 (-4.1A)
GLC  A 504 (-4.8A)
ACI  A 505 (-3.1A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
GLC  A 504 (-2.8A)
GLC  A 504 (-2.6A)
 0.74A 1dedA-4e2oA:
43.3		 1dedA-4e2oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		8 / 12 HIS A 102
TYR A 104
TYR A 182
ASP A 217
GLU A 246
ASP A 314
ASP A 362
ARG A 366
 GLC  A 504 ( 3.7A)
ACI  A 505 (-4.1A)
BGC  A 507 (-4.7A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-2.8A)
GLC  A 504 (-2.8A)
GLC  A 504 (-2.6A)
 1.16A 1dedA-4e2oA:
43.3		 1dedA-4e2oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		8 / 12 HIS A 102
TYR A 104
TYR A 182
ASP A 217
HIS A 313
ASP A 314
ASP A 362
ARG A 366
 GLC  A 504 ( 3.7A)
ACI  A 505 (-4.1A)
BGC  A 507 (-4.7A)
ACI  A 505 (-3.1A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
GLC  A 504 (-2.8A)
GLC  A 504 (-2.6A)
 0.89A 1dedA-4e2oA:
43.3		 1dedA-4e2oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		10 / 12 HIS A 102
TYR A 104
TYR A 182
LEU A 184
ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
ARG A 366
 GLC  A 504 ( 3.7A)
ACI  A 505 (-4.1A)
BGC  A 507 (-4.7A)
GLC  A 504 (-4.8A)
ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
GLC  A 504 (-2.6A)
 0.80A 1dedB-4e2oA:
41.3		 1dedB-4e2oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 9 VAL A 136
VAL A  73
LEU A 125
ILE A  80
LEU A  90
 None
 1.11A 1eqgA-4e2oA:
undetectable		 1eqgA-4e2oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 11 VAL A 136
VAL A  73
LEU A 125
ILE A  80
LEU A  90
 None
 1.11A 1eqgB-4e2oA:
undetectable		 1eqgB-4e2oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 8 GLU A 469
ALA A 336
GLU A 376
ALA A 356
THR A 319
 None
 1.47A 1ie4B-4e2oA:
undetectable
1ie4D-4e2oA:
undetectable		 1ie4B-4e2oA:
16.05
1ie4D-4e2oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		8 / 12 TYR A 104
HIS A 144
ARG A 215
ASP A 217
GLU A 246
TRP A 248
HIS A 313
ASP A 314
 ACI  A 505 (-4.1A)
ACI  A 505 (-3.9A)
ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
BGC  A 507 (-3.8A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.28A 1mxdA-4e2oA:
32.9		 1mxdA-4e2oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 LEU A 310
GLY A  84
GLY A 385
ILE A 384
PRO A 347
 None
 0.94A 1sdvA-4e2oA:
undetectable		 1sdvA-4e2oA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 ILE A 106
TRP A 227
PHE A 226
GLN A 189
VAL A 222
 None
None
None
CA  A 501 ( 4.8A)
CA  A 501 ( 4.8A)
 1.45A 2jj8D-4e2oA:
0.0		 2jj8D-4e2oA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.68A 3aicA-4e2oA:
5.3		 3aicA-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.64A 3aicB-4e2oA:
9.6		 3aicB-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		6 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
TYR A 104
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
ACI  A 505 (-4.1A)
 0.65A 3aicC-4e2oA:
9.9		 3aicC-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.74A 3aicD-4e2oA:
4.6		 3aicD-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.71A 3aicE-4e2oA:
4.7		 3aicE-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.65A 3aicF-4e2oA:
9.9		 3aicF-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.64A 3aicG-4e2oA:
4.8		 3aicG-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.73A 3aicH-4e2oA:
4.7		 3aicH-4e2oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 9 GLY A 259
GLN A 228
ASP A 257
VAL A 247
VAL A 219
 None
 1.38A 3fi0D-4e2oA:
undetectable		 3fi0D-4e2oA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 9 GLY A 259
GLN A 228
ASP A 257
VAL A 247
VAL A 219
 None
 1.34A 3fi0F-4e2oA:
undetectable		 3fi0F-4e2oA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		3 / 3 MET A  42
MET A  49
PHE A  66
 None
 1.33A 3gn8A-4e2oA:
undetectable		 3gn8A-4e2oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 LEU A 122
THR A  74
VAL A  73
ALA A 129
 None
 0.88A 3uniB-4e2oA:
undetectable		 3uniB-4e2oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 TYR A 351
ILE A 355
TYR A 350
ASP A 311
ILE A 333
 None
 1.43A 3uprA-4e2oA:
undetectable		 3uprA-4e2oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 TYR A 351
ILE A 355
TYR A 350
ASP A 311
ILE A 333
 None
 1.48A 3uprC-4e2oA:
undetectable		 3uprC-4e2oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 5 ASP A 291
GLU A 404
TYR A 290
GLU A 294
 None
 1.38A 3w9tA-4e2oA:
undetectable		 3w9tA-4e2oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 5 ASP A 291
GLU A 404
TYR A 290
GLU A 294
 None
 1.39A 3w9tC-4e2oA:
undetectable		 3w9tC-4e2oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 5 ASP A 291
GLU A 404
TYR A 290
GLU A 294
 None
 1.39A 3w9tD-4e2oA:
undetectable		 3w9tD-4e2oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 5 ASP A 291
GLU A 404
TYR A 290
GLU A 294
 None
 1.39A 3w9tG-4e2oA:
undetectable		 3w9tG-4e2oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 LEU A 138
LEU A  70
ASP A  69
ASN A  47
ILE A  93
 None
 1.14A 3wdmD-4e2oA:
undetectable		 3wdmD-4e2oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.15A 4feuB-4e2oA:
undetectable		 4feuB-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.18A 4feuF-4e2oA:
undetectable		 4feuF-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.18A 4fevD-4e2oA:
undetectable		 4fevD-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.17A 4fevF-4e2oA:
undetectable		 4fevF-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.22A 4fewB-4e2oA:
undetectable		 4fewB-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.17A 4fewD-4e2oA:
undetectable		 4fewD-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.20A 4fewF-4e2oA:
undetectable		 4fewF-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.18A 4fexB-4e2oA:
undetectable		 4fexB-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 6 GLY A 103
ASN A  96
TYR A  65
GLY A  68
 None
 0.91A 4fjpA-4e2oA:
undetectable		 4fjpA-4e2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ILE A 346
PRO A 347
ARG A 388
GLY A 385
 None
 0.98A 4g0uB-4e2oA:
undetectable		 4g0uB-4e2oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		3 / 3 GLU A  36
ASP A  35
ASP A 240
 None
 0.78A 4gc9A-4e2oA:
undetectable		 4gc9A-4e2oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.17A 4gkhB-4e2oA:
3.0		 4gkhB-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.20A 4gkhG-4e2oA:
2.0		 4gkhG-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 6 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.24A 4gkhJ-4e2oA:
2.9		 4gkhJ-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.18A 4gkiA-4e2oA:
undetectable		 4gkiA-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 8 ASP A 463
ASN A 437
ASP A 458
GLU A 459
 None
 1.19A 4gkiC-4e2oA:
undetectable		 4gkiC-4e2oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 ASP A 113
VAL A  57
TYR A  65
GLY A 117
GLY A  68
 None
 1.35A 4mmdA-4e2oA:
undetectable		 4mmdA-4e2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 9 ASP A 113
VAL A  57
TYR A  65
GLY A 117
GLY A  68
 None
 1.31A 4mmeA-4e2oA:
undetectable		 4mmeA-4e2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 9 ASP A 113
VAL A  57
TYR A  65
GLY A 117
GLY A  68
 None
 1.32A 4mmeB-4e2oA:
undetectable		 4mmeB-4e2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 6 LYS A 320
ASN A 328
PRO A 329
ARG A 367
 None
 1.31A 4yv5A-4e2oA:
undetectable		 4yv5A-4e2oA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 LEU A 476
PRO A 441
LEU A 446
TYR A 462
 None
 1.01A 4z4fA-4e2oA:
2.0		 4z4fA-4e2oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 12 ARG A 215
ASP A 217
GLU A 246
HIS A 313
ASP A 314
 ACI  A 505 (-3.3A)
ACI  A 505 (-3.1A)
G6D  A 506 (-2.7A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.41A 5csyB-4e2oA:
6.0		 5csyB-4e2oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 5 ASP A 268
GLY A 273
PRO A 270
TRP A 248
 None
None
None
BGC  A 507 (-3.8A)
 1.43A 5nn8A-4e2oA:
13.8		 5nn8A-4e2oA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		4 / 7 LEU A 476
PRO A 441
LEU A 446
TYR A 462
 None
 1.07A 5t7bA-4e2oA:
undetectable		 5t7bA-4e2oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 TYR A 351
ILE A 355
TYR A 350
ASP A 311
ILE A 333
 None
 1.46A 5u98A-4e2oA:
undetectable		 5u98A-4e2oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		5 / 10 TYR A 351
ILE A 355
TYR A 350
ASP A 311
ILE A 333
 None
 1.45A 5u98D-4e2oA:
undetectable		 5u98D-4e2oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 4e2o ALPHA-AMYLASE
(Geobacillus
thermoleovorans) 		6 / 12 TYR A 104
HIS A 144
ASP A 217
HIS A 221
HIS A 313
ASP A 314
 ACI  A 505 (-4.1A)
ACI  A 505 (-3.9A)
ACI  A 505 (-3.1A)
G6D  A 506 ( 3.9A)
ACI  A 505 (-3.7A)
ACI  A 505 (-2.8A)
 0.45A 6ag0A-4e2oA:
29.1		 6ag0A-4e2oA:
10.57