SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 7 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.80A 1c9sT-4e2pA:
undetectable
1c9sU-4e2pA:
undetectable		 1c9sT-4e2pA:
10.50
1c9sU-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.81A 1c9sU-4e2pA:
undetectable
1c9sV-4e2pA:
undetectable		 1c9sU-4e2pA:
10.50
1c9sV-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 7 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.84A 1gtfL-4e2pA:
undetectable
1gtfM-4e2pA:
undetectable		 1gtfL-4e2pA:
10.50
1gtfM-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.82A 1gtfN-4e2pA:
undetectable
1gtfO-4e2pA:
undetectable		 1gtfN-4e2pA:
10.50
1gtfO-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 4 VAL A  98
LEU A 360
ILE A 245
LEU A 244
 None
None
None
HEM  A 401 (-3.6A)
 0.91A 2byoA-4e2pA:
undetectable		 2byoA-4e2pA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 7 ARG A 263
VAL A 262
ARG A 266
ILE A 269
 None
 1.10A 2yfbA-4e2pA:
1.8		 2yfbA-4e2pA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 6 ARG A 263
VAL A 262
ARG A 266
ILE A 269
 None
 1.10A 2yfbB-4e2pA:
undetectable		 2yfbB-4e2pA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		5 / 12 VAL A 389
PHE A 367
LEU A 113
ALA A 127
PHE A 122
 None
 1.24A 3apxA-4e2pA:
undetectable		 3apxA-4e2pA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		3 / 3 ALA A 236
THR A 240
CYH A 346
 HEM  A 401 (-2.9A)
HEM  A 401 (-3.3A)
HEM  A 401 (-2.2A)
 0.62A 3e4eA-4e2pA:
29.8		 3e4eA-4e2pA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		3 / 3 ALA A 236
THR A 240
CYH A 346
 HEM  A 401 (-2.9A)
HEM  A 401 (-3.3A)
HEM  A 401 (-2.2A)
 0.54A 3e4eB-4e2pA:
29.7		 3e4eB-4e2pA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		5 / 10 LEU A 272
GLY A 356
LEU A 363
VAL A 262
ILE A 269
 None
 0.87A 3em3A-4e2pA:
undetectable		 3em3A-4e2pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 GLY A  72
PHE A 229
ILE A 212
MET A 208
 None
 0.92A 3ko0O-4e2pA:
undetectable
3ko0Q-4e2pA:
undetectable		 3ko0O-4e2pA:
12.71
3ko0Q-4e2pA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 5 SER A 281
GLY A  39
GLU A  45
GLU A  42
 None
 1.50A 3raeB-4e2pA:
1.3
3raeD-4e2pA:
undetectable		 3raeB-4e2pA:
22.66
3raeD-4e2pA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		5 / 12 LEU A 140
CYH A 346
VAL A 137
MET A 155
THR A 241
 None
HEM  A 401 (-2.2A)
HEM  A 401 (-4.4A)
None
HEM  A 401 (-4.4A)
 1.49A 4iarA-4e2pA:
undetectable		 4iarA-4e2pA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		5 / 12 GLY A 356
LEU A 351
LEU A 272
GLY A 237
PHE A 339
 None
None
None
HEM  A 401 (-3.4A)
None
 1.08A 5d4uB-4e2pA:
undetectable		 5d4uB-4e2pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 THR A 286
GLY A 340
ALA A  43
HIS A 344
 HEM  A 401 (-3.3A)
HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
 0.84A 5eezL-4e2pA:
undetectable
5eezV-4e2pA:
undetectable		 5eezL-4e2pA:
10.50
5eezV-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 THR A 286
GLY A 340
ALA A  43
HIS A 344
 HEM  A 401 (-3.3A)
HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
 0.84A 5ef1L-4e2pA:
undetectable
5ef1V-4e2pA:
undetectable		 5ef1L-4e2pA:
10.50
5ef1V-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		4 / 8 THR A 286
GLY A 340
ALA A  43
HIS A 344
 HEM  A 401 (-3.3A)
HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
 0.84A 5ef2L-4e2pA:
undetectable
5ef2V-4e2pA:
undetectable		 5ef2L-4e2pA:
10.50
5ef2V-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4e2p CYTOCHROME P450
107B1 (P450CVIIB1)
(Streptomyces
himastatinicus) 		5 / 9 LEU A 360
LEU A 273
MET A 125
LEU A 124
PRO A 282
 None
None
None
None
HEM  A 401 (-3.9A)
 1.35A 5og9A-4e2pA:
30.9		 5og9A-4e2pA:
23.76