SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 HIS A 159
PHE A 172
LEU A 125
ILE A 126
 None
 1.09A 1sbrA-4e2sA:
undetectable
1sbrB-4e2sA:
undetectable		 1sbrA-4e2sA:
22.43
1sbrB-4e2sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 8 PHE A 225
PHE A 204
GLU A 202
TYR A 252
 None
 1.38A 2aoxA-4e2sA:
undetectable		 2aoxA-4e2sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 7 PHE A 225
PHE A 204
GLU A 202
TYR A 252
 None
 1.37A 2aoxB-4e2sA:
undetectable		 2aoxB-4e2sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 SER A 190
ASP A 192
SER A 149
VAL A 188
 None
 1.29A 2hdnI-4e2sA:
undetectable
2hdnJ-4e2sA:
undetectable
2hdnL-4e2sA:
undetectable		 2hdnI-4e2sA:
10.08
2hdnJ-4e2sA:
21.10
2hdnL-4e2sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 VAL A 273
ASP A 256
LYS A  66
TYR A 259
 None
 1.49A 2zs9A-4e2sA:
undetectable		 2zs9A-4e2sA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 125
VAL A 188
LEU A 161
LEU A 246
 None
 0.77A 3g8iA-4e2sA:
undetectable		 3g8iA-4e2sA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 PHE A 102
ASP A 292
TYR A 290
PRO A  96
 None
 1.38A 3jqaA-4e2sA:
undetectable		 3jqaA-4e2sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 PHE A 102
ASP A 292
TYR A 290
PRO A  96
 None
 1.36A 3jqaB-4e2sA:
undetectable		 3jqaB-4e2sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 PHE A 102
ASP A 292
TYR A 290
PRO A  96
 None
 1.39A 3jqaC-4e2sA:
undetectable		 3jqaC-4e2sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 6 PHE A 102
ASP A 292
TYR A 290
PRO A  96
 None
 1.38A 3jqaD-4e2sA:
undetectable		 3jqaD-4e2sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 5 ARG A 284
ASP A 148
ASP A 192
ARG A 207
 None
 1.34A 3naiA-4e2sA:
undetectable		 3naiA-4e2sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 7 MET A 269
LEU A 254
LEU A 289
TRP A 268
 UGY  A 302 (-3.6A)
None
UGY  A 302 ( 4.9A)
None
 1.29A 3nk2X-4e2sA:
undetectable		 3nk2X-4e2sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 210
LEU A 209
ILE A 187
TYR A 150
PHE A 127
 None
 1.13A 4a7aB-4e2sA:
undetectable		 4a7aB-4e2sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 107
THR A 168
ALA A 167
THR A  88
 None
 0.63A 4qw0K-4e2sA:
undetectable		 4qw0K-4e2sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 107
THR A 168
ALA A 167
THR A  88
 None
 0.64A 4qw0Y-4e2sA:
undetectable		 4qw0Y-4e2sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		3 / 3 GLN A 240
HIS A 101
ARG A 174
 None
 1.29A 4qyqA-4e2sA:
undetectable		 4qyqA-4e2sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		3 / 3 GLN A 240
HIS A 101
ARG A 174
 None
 1.25A 4qyqB-4e2sA:
undetectable		 4qyqB-4e2sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4e2s UREIDOGLYCINE
AMINOHYDROLASE
(Arabidopsis
thaliana) 		3 / 3 TYR A 152
ALA A 215
TYR A 216
 None
 0.62A 5uunB-4e2sA:
undetectable		 5uunB-4e2sA:
20.95