SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  76
ILE A  77
LEU A 170
VAL A  95
LEU A  87
 None
 1.02A 2bxfB-4e2uA:
undetectable		 2bxfB-4e2uA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		5 / 9 ASN A 172
ILE A 156
ILE A  68
ASP A 153
ALA A  65
 None
 1.26A 2dtjA-4e2uA:
undetectable
2dtjB-4e2uA:
undetectable		 2dtjA-4e2uA:
25.26
2dtjB-4e2uA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 170
ALA A 107
ARG A  99
LEU A  81
THR A   6
 None
 1.17A 2oaxB-4e2uA:
undetectable		 2oaxB-4e2uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 155
SER A  92
THR A  90
ALA A   1
ASP A 153
 None
 1.44A 2qm9A-4e2uA:
undetectable		 2qm9A-4e2uA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		4 / 7 TYR A   9
VAL A  48
TYR A  51
ILE A 156
 None
 1.32A 2xz5B-4e2uA:
undetectable
2xz5E-4e2uA:
undetectable		 2xz5B-4e2uA:
19.91
2xz5E-4e2uA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 170
ALA A 107
ARG A  99
LEU A  81
THR A   6
 None
 1.19A 3vhuA-4e2uA:
undetectable		 3vhuA-4e2uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		4 / 6 TYR A  10
ILE A 156
VAL A  48
ALA A  65
 None
 0.88A 5cu6A-4e2uA:
undetectable		 5cu6A-4e2uA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		4 / 7 HIS A 160
ILE A 156
VAL A 155
ARG A  64
 None
 1.17A 5kkzC-4e2uA:
undetectable
5kkzE-4e2uA:
undetectable		 5kkzC-4e2uA:
22.22
5kkzE-4e2uA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4e2u PHO RADA INTEIN
(Pyrococcus
horikoshii) 		4 / 7 HIS A 160
ILE A 156
VAL A 155
ARG A  64
 None
 1.15A 5kkzK-4e2uA:
undetectable
5kkzQ-4e2uA:
undetectable		 5kkzK-4e2uA:
16.67
5kkzQ-4e2uA:
22.22