SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1426_0
(FPRA)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 4 ASP A  42
HIS A 362
ARG A  36
GLU A  44
 None
 1.49A 1lquA-4e2zA:
0.0		 1lquA-4e2zA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 TYR A 407
THR A 333
VAL A 343
ILE A 338
 None
 0.98A 1p7rA-4e2zA:
undetectable		 1p7rA-4e2zA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 MET A  71
THR A  63
LEU A  62
VAL A  66
TYR A 222
 None
 1.31A 1wsvA-4e2zA:
undetectable		 1wsvA-4e2zA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 10 ILE A 118
HIS A 254
TYR A 174
GLU A 111
ASN A 177
 None
JHZ  A 504 (-3.9A)
None
SAH  A 503 ( 4.8A)
SAH  A 503 ( 3.9A)
 1.46A 2jkcA-4e2zA:
0.0		 2jkcA-4e2zA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 LEU A 179
ALA A 175
LEU A 262
LEU A 196
PHE A 133
 None
 1.34A 2oaxF-4e2zA:
undetectable		 2oaxF-4e2zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 6 ALA A 158
ASP A 161
GLU A 156
ARG A  68
 None
 1.20A 2ouzA-4e2zA:
undetectable		 2ouzA-4e2zA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 LEU A 380
GLY A 324
GLY A 322
VAL A 365
THR A 326
 None
JHZ  A 504 (-3.6A)
None
None
JHZ  A 504 (-4.0A)
 1.22A 3dh0A-4e2zA:
14.5		 3dh0A-4e2zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 1.03A 3g89A-4e2zA:
10.0		 3g89A-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 0.94A 3g8bA-4e2zA:
10.2		 3g8bA-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 504 (-3.6A)
JHZ  A 504 (-2.7A)
JHZ  A 504 (-4.2A)
JHZ  A 504 (-2.9A)
JHZ  A 504 (-3.6A)
 1.02A 3g8bB-4e2zA:
9.9		 3g8bB-4e2zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4e2z TCAB9
(Micromonospora
chalcea) 		3 / 3 MET A  71
CYH A 180
PRO A 183
 None
 1.29A 3h52C-4e2zA:
undetectable		 3h52C-4e2zA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		12 / 12 PHE A  72
TYR A  76
TYR A  78
PHE A  90
GLU A 111
ILE A 112
PHE A 133
PHE A 154
PHE A 155
ALA A 176
THR A 178
ILE A 182
 SAH  A 503 (-3.6A)
SAH  A 503 ( 4.4A)
JHZ  A 504 (-3.2A)
SAH  A 503 (-4.5A)
SAH  A 503 ( 4.8A)
SAH  A 503 (-4.5A)
None
SAH  A 503 (-4.9A)
None
SAH  A 503 (-3.5A)
SAH  A 503 (-3.3A)
SAH  A 503 (-4.4A)
 0.16A 3ndiA-4e2zA:
70.4		 3ndiA-4e2zA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		6 / 9 SER A  80
GLY A 113
ASN A 115
GLU A 134
ASN A 177
HIS A 181
 SAH  A 503 (-2.7A)
SAH  A 503 (-3.4A)
SAH  A 503 (-4.3A)
SAH  A 503 (-2.7A)
SAH  A 503 ( 3.9A)
SAH  A 503 (-4.4A)
 0.79A 3ndiA-4e2zA:
70.4		 3ndiA-4e2zA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		8 / 9 SER A  80
GLY A 113
ASN A 115
GLU A 134
PRO A 135
SER A 136
ASN A 177
TYR A 184
 SAH  A 503 (-2.7A)
SAH  A 503 (-3.4A)
SAH  A 503 (-4.3A)
SAH  A 503 (-2.7A)
SAH  A 503 (-3.8A)
SAH  A 503 (-2.7A)
SAH  A 503 ( 3.9A)
None
 0.13A 3ndiA-4e2zA:
70.4		 3ndiA-4e2zA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 TYR A  76
ASP A  33
SER A  32
HIS A 181
 SAH  A 503 ( 4.4A)
JHZ  A 504 ( 4.4A)
None
SAH  A 503 (-4.4A)
 1.29A 4arcA-4e2zA:
undetectable		 4arcA-4e2zA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 10 MET A  86
PHE A  90
LEU A  93
ALA A 238
MET A 237
 None
SAH  A 503 (-4.5A)
None
None
None
 1.48A 4fe1A-4e2zA:
undetectable
4fe1J-4e2zA:
undetectable		 4fe1A-4e2zA:
19.73
4fe1J-4e2zA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 8 GLY A 242
GLY A 266
VAL A 246
GLU A 244
 None
 0.73A 4fgzB-4e2zA:
14.5		 4fgzB-4e2zA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 6 ARG A 259
ASP A  96
VAL A 128
ALA A 126
 None
 0.91A 4nkxA-4e2zA:
undetectable		 4nkxA-4e2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 JHZ  A 504 ( 4.9A)
JHZ  A 504 (-4.0A)
JHZ  A 504 (-3.6A)
None
 1.04A 4qw0K-4e2zA:
undetectable		 4qw0K-4e2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 JHZ  A 504 ( 4.9A)
JHZ  A 504 (-4.0A)
JHZ  A 504 (-3.6A)
None
 1.03A 4qw0Y-4e2zA:
undetectable		 4qw0Y-4e2zA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4e2z TCAB9
(Micromonospora
chalcea) 		6 / 12 TYR A  76
ILE A 112
GLY A 113
PRO A 135
PHE A 155
ILE A 182
 SAH  A 503 ( 4.4A)
SAH  A 503 (-4.5A)
SAH  A 503 (-3.4A)
SAH  A 503 (-3.8A)
None
SAH  A 503 (-4.4A)
 0.33A 4rvdA-4e2zA:
21.3		 4rvdA-4e2zA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4e2z TCAB9
(Micromonospora
chalcea) 		6 / 12 ILE A 112
GLY A 113
ASN A 115
PRO A 135
PHE A 155
ILE A 182
 SAH  A 503 (-4.5A)
SAH  A 503 (-3.4A)
SAH  A 503 (-4.3A)
SAH  A 503 (-3.8A)
None
SAH  A 503 (-4.4A)
 0.31A 4rvgA-4e2zA:
54.1		 4rvgA-4e2zA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 SER A  80
GLY A 113
GLU A 134
VAL A 188
ILE A 182
 SAH  A 503 (-2.7A)
SAH  A 503 (-3.4A)
SAH  A 503 (-2.7A)
None
SAH  A 503 (-4.4A)
 0.87A 5ec8A-4e2zA:
6.1		 5ec8A-4e2zA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4e2z TCAB9
(Micromonospora
chalcea) 		4 / 6 GLU A 281
TYR A 208
GLY A 256
GLY A 255
 None
 0.90A 5x7pB-4e2zA:
undetectable		 5x7pB-4e2zA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4e2z TCAB9
(Micromonospora
chalcea) 		5 / 12 VAL A 234
ALA A 158
LEU A 179
PHE A 202
LEU A 262
 None
 1.43A 6a7pB-4e2zA:
undetectable		 6a7pB-4e2zA:
21.72