SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 265
PHE A 210
LYS A 213
VAL A 261
 None
 1.46A 1l2iB-4e37A:
undetectable		 1l2iB-4e37A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 396
PHE A 398
GLU A 400
GLN A 395
 None
 1.41A 1l2iB-4e37A:
undetectable		 1l2iB-4e37A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 128
TYR A 338
SER A 113
 HEM  A 500 (-3.1A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.7A)
 0.88A 2gvcB-4e37A:
undetectable		 2gvcB-4e37A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 128
TYR A 338
SER A 113
 HEM  A 500 (-3.1A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.7A)
 0.88A 2gvcE-4e37A:
undetectable		 2gvcE-4e37A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 183
GLY A 184
SER A 241
 NDP  A 501 (-2.6A)
None
None
 0.54A 2xctB-4e37A:
undetectable		 2xctB-4e37A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 224
ASP A 179
GLN A 175
 None
 0.76A 3eeyC-4e37A:
undetectable		 3eeyC-4e37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 224
ASP A 179
GLN A 175
 None
 0.76A 3eeyD-4e37A:
undetectable		 3eeyD-4e37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 224
ASP A 179
GLN A 175
 None
 0.75A 3eeyE-4e37A:
undetectable		 3eeyE-4e37A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 4 MET A 330
LYS A 329
ASP A 328
ASP A 137
 HEM  A 500 (-4.0A)
None
None
None
 1.15A 3ncqB-4e37A:
0.0		 3ncqB-4e37A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 253
SER A 248
GLU A 223
HIS A 191
 None
 1.29A 4aq7A-4e37A:
undetectable		 4aq7A-4e37A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 4 PRO A 467
LEU A 463
ILE A 459
ARG A 456
 None
 1.21A 4f4dA-4e37A:
undetectable		 4f4dA-4e37A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 100
TYR A 338
ASN A 356
 None
HEM  A 500 (-4.0A)
None
 0.53A 4ffwB-4e37A:
undetectable		 4ffwB-4e37A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 337
LEU A 331
TYR A 338
PRO A 142
 HEM  A 500 (-3.5A)
None
HEM  A 500 (-4.0A)
None
 1.48A 4jksB-4e37A:
undetectable		 4jksB-4e37A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 337
LEU A 331
TYR A 338
PRO A 142
 HEM  A 500 (-3.5A)
None
HEM  A 500 (-4.0A)
None
 1.50A 4jkuA-4e37A:
undetectable		 4jkuA-4e37A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 337
LEU A 331
TYR A 338
PRO A 142
 HEM  A 500 (-3.5A)
None
HEM  A 500 (-4.0A)
None
 1.49A 4kalB-4e37A:
undetectable		 4kalB-4e37A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 467
LEU A 463
ILE A 459
ARG A 456
 None
 0.94A 4klrA-4e37A:
undetectable		 4klrA-4e37A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 127
ASP A 124
PRO A 316
ARG A 334
 HEM  A 500 (-3.8A)
None
None
HEM  A 500 (-3.5A)
 1.08A 4lajA-4e37A:
undetectable
4lajB-4e37A:
undetectable		 4lajA-4e37A:
19.69
4lajB-4e37A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 196
ASP A 124
PRO A 316
ARG A 334
 None
None
None
HEM  A 500 (-3.5A)
 0.96A 4lajA-4e37A:
undetectable
4lajB-4e37A:
undetectable		 4lajA-4e37A:
19.69
4lajB-4e37A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 101
GLU A  99
GLU A 106
ALA A 105
 None
 0.85A 4rjdA-4e37A:
undetectable
4rjdB-4e37A:
undetectable		 4rjdA-4e37A:
9.79
4rjdB-4e37A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 338
ASP A 328
VAL A 126
GLY A 127
 HEM  A 500 (-4.0A)
None
HEM  A 500 (-4.9A)
HEM  A 500 (-3.8A)
 0.97A 5nzyA-4e37A:
undetectable		 5nzyA-4e37A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 458
TRP A 163
VAL A 450
 None
 1.16A 6auuA-4e37A:
undetectable		 6auuA-4e37A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 164
GLN A 458
LEU A 176
SER A 172
 None
 1.26A 6ekuA-4e37A:
undetectable		 6ekuA-4e37A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4e37 CATALASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 179
TYR A 134
SER A 337
ASN A 128
 None
None
HEM  A 500 (-3.5A)
HEM  A 500 (-3.1A)
 1.00A 6giqL-4e37A:
undetectable
6giqP-4e37A:
undetectable
6giqT-4e37A:
undetectable		 6giqL-4e37A:
22.03
6giqP-4e37A:
17.22
6giqT-4e37A:
10.12