SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 11 LEU A  67
ILE A 254
GLY A 252
TYR A  91
HIS A 280
 None
 1.23A 1s9aA-4e3eA:
undetectable		 1s9aA-4e3eA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 5 TYR A 143
SER A 110
SER A 130
THR A  77
 None
 1.11A 1yvpA-4e3eA:
undetectable		 1yvpA-4e3eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 6 TYR A 143
SER A 110
SER A 130
THR A  77
 None
 1.11A 1yvpB-4e3eA:
undetectable		 1yvpB-4e3eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 11 HIS A 219
HIS A 233
ILE A 214
THR A 223
ASN A 228
 None
 1.37A 2gl0B-4e3eA:
undetectable
2gl0C-4e3eA:
undetectable		 2gl0B-4e3eA:
18.64
2gl0C-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 214
THR A 223
ASN A 228
HIS A 219
HIS A 233
 None
 1.42A 2gl0A-4e3eA:
undetectable
2gl0C-4e3eA:
undetectable		 2gl0A-4e3eA:
18.64
2gl0C-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 HIS A 219
HIS A 233
ILE A 214
THR A 223
ASN A 228
 None
 1.39A 2gl0D-4e3eA:
undetectable
2gl0E-4e3eA:
undetectable		 2gl0D-4e3eA:
18.64
2gl0E-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 HIS A 219
ILE A 214
THR A 223
ASN A 228
VAL A 340
 None
 1.46A 2gl0D-4e3eA:
undetectable
2gl0E-4e3eA:
undetectable		 2gl0D-4e3eA:
18.64
2gl0E-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 7 TYR A 143
SER A 110
SER A 130
THR A  77
 None
 1.08A 2i91B-4e3eA:
undetectable		 2i91B-4e3eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 PHE A  45
ALA A 267
SER A 294
ARG A 259
TYR A 345
 None
 0.98A 2qm9A-4e3eA:
undetectable		 2qm9A-4e3eA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 6 SER A 294
ALA A 292
HIS A 208
ASP A 207
 None
 1.33A 3aruA-4e3eA:
undetectable		 3aruA-4e3eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 LEU A  67
ILE A 254
GLY A 252
TYR A  91
HIS A 280
 None
 1.20A 3hgiA-4e3eA:
undetectable		 3hgiA-4e3eA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 ASN A 228
THR A 108
ILE A  21
ILE A  81
SER A  82
 None
 1.19A 3kpbA-4e3eA:
undetectable		 3kpbA-4e3eA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 8 TYR A  41
TYR A  37
TYR A 250
LEU A 341
 None
 1.42A 3uzzB-4e3eA:
undetectable		 3uzzB-4e3eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 THR A 223
SER A 130
GLY A  90
SER A 256
TYR A  41
 None
 1.32A 4kn2C-4e3eA:
undetectable		 4kn2C-4e3eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 8 PHE A  74
PHE A  70
PHE A 343
GLY A  90
 None
 0.99A 4qoiA-4e3eA:
undetectable
4qoiB-4e3eA:
undetectable		 4qoiA-4e3eA:
19.83
4qoiB-4e3eA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		3 / 3 ARG A 305
ASP A 307
TYR A 179
 None
 0.52A 4yo9B-4e3eA:
undetectable		 4yo9B-4e3eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 7 PHE A  70
ILE A 275
PHE A  74
GLY A 252
 None
 0.94A 4zdzA-4e3eA:
undetectable		 4zdzA-4e3eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 5 TYR A 143
GLY A  75
TYR A  91
GLY A 251
 None
 0.95A 5ayfA-4e3eA:
undetectable		 5ayfA-4e3eA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 PHE A  70
ILE A 275
PHE A  74
VAL A 112
GLY A 252
 None
 0.98A 5esgA-4e3eA:
undetectable		 5esgA-4e3eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 LEU A 115
PHE A  70
ILE A 275
PHE A  74
GLY A 252
 None
 1.06A 5eshA-4e3eA:
undetectable		 5eshA-4e3eA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 6 GLY A 265
ASP A  65
ILE A 255
TYR A 345
 None
 0.81A 5iwuA-4e3eA:
undetectable		 5iwuA-4e3eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 210
LEU A 341
ALA A 258
GLY A 265
LEU A 266
 None
 1.17A 5m5cB-4e3eA:
undetectable		 5m5cB-4e3eA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 10 ASP A 210
LEU A 341
ALA A 258
GLY A 265
LEU A 266
 None
 1.18A 5m5cE-4e3eA:
undetectable		 5m5cE-4e3eA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 6 ALA A 267
LEU A 266
TYR A 200
SER A 193
 None
 0.89A 5phhA-4e3eA:
undetectable		 5phhA-4e3eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 7 ILE A  72
LEU A 106
ILE A 275
ALA A  98
 None
 0.88A 6b5vA-4e3eA:
undetectable
6b5vC-4e3eA:
undetectable		 6b5vA-4e3eA:
13.21
6b5vC-4e3eA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		4 / 7 ILE A  72
LEU A 106
ILE A 275
ALA A  98
 None
 0.88A 6b5vC-4e3eA:
undetectable
6b5vD-4e3eA:
undetectable		 6b5vC-4e3eA:
13.21
6b5vD-4e3eA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE
(Chloroflexus
aurantiacus) 		5 / 10 VAL A  34
LEU A  68
LEU A  47
GLY A 103
ARG A  61
 None
 1.11A 6eu9B-4e3eA:
undetectable		 6eu9B-4e3eA:
11.75