SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 6 PRO A 310
MET A 312
ASP A 321
TYR A 326
 None
 1.42A 2lh8A-4e3wA:
undetectable		 2lh8A-4e3wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 0.89A 2nmyB-4e3wA:
undetectable		 2nmyB-4e3wA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 0.91A 2rkfA-4e3wA:
undetectable		 2rkfA-4e3wA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		3 / 3 MET A  13
GLU A  48
ASN A  46
 None
 1.07A 3a27A-4e3wA:
undetectable		 3a27A-4e3wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 10 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 0.89A 3ekpB-4e3wA:
undetectable		 3ekpB-4e3wA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 10 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 0.85A 3ekpC-4e3wA:
undetectable		 3ekpC-4e3wA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 9 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 0.84A 3ektB-4e3wA:
undetectable		 3ektB-4e3wA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 10 ALA A 211
ASP A 207
GLY A 184
ILE A 181
ALA A 159
 None
 1.03A 3t3cB-4e3wA:
undetectable		 3t3cB-4e3wA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ALA A  29
LEU A 170
THR A 182
ALA A 190
ILE A 209
 None
 0.96A 4o2bD-4e3wA:
undetectable		 4o2bD-4e3wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ALA A  29
LEU A 170
THR A 182
ALA A 190
ILE A 209
 None
 0.87A 4x20B-4e3wA:
undetectable		 4x20B-4e3wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 SER A  88
TYR A 256
GLU A  48
TYR A 302
LEU A 285
 None
 1.32A 5czyA-4e3wA:
undetectable		 5czyA-4e3wA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4e3w ACID PHOSPHATASE
(Francisella
tularensis) 		5 / 12 ALA A  29
LEU A 170
THR A 182
ALA A 190
ILE A 209
 None
 0.86A 5xiwB-4e3wA:
undetectable		 5xiwB-4e3wA:
12.57