SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 8 GLY A 190
ARG A 188
ILE A 149
LEU A 150
 None
 0.86A 1jg4A-4e3zA:
4.3		 1jg4A-4e3zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A  59
GLY A  12
ALA A  90
VAL A  46
ALA A  41
 None
 1.12A 1sg9C-4e3zA:
6.4		 1sg9C-4e3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 7 ILE A 243
LEU A 231
ILE A 166
ASP A 167
 None
 0.94A 1yc2E-4e3zA:
5.4		 1yc2E-4e3zA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 11 LEU A   8
LEU A  86
ARG A 128
VAL A 126
ALA A 123
 None
 1.16A 2q72A-4e3zA:
undetectable		 2q72A-4e3zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A   8
LEU A  86
ARG A 128
VAL A 126
ALA A 123
 None
 1.15A 2qb4A-4e3zA:
undetectable		 2qb4A-4e3zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 GLU A 176
ARG A 183
ALA A 236
LEU A 232
ILE A 182
 None
 1.31A 2xkwB-4e3zA:
undetectable		 2xkwB-4e3zA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 5 LEU A 120
GLY A 117
PHE A  73
ASN A 142
 None
 1.27A 3uq6B-4e3zA:
6.8		 3uq6B-4e3zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		3 / 3 THR A  50
VAL A  46
GLU A  55
 None
 0.61A 3v4tA-4e3zA:
undetectable
3v4tD-4e3zA:
undetectable		 3v4tA-4e3zA:
22.54
3v4tD-4e3zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 8 GLY A  15
GLY A  17
VAL A  45
CYH A  21
 None
 0.84A 4c5nC-4e3zA:
7.4		 4c5nC-4e3zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 6 ARG A 127
ILE A 182
VAL A 177
LEU A 173
 None
 1.05A 4em2A-4e3zA:
undetectable		 4em2A-4e3zA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 8 ARG A  22
ILE A 228
ALA A 225
LEU A 229
 None
 0.83A 5te8B-4e3zA:
undetectable		 5te8B-4e3zA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 8 ILE A  16
TYR A 159
VAL A 187
ASP A 226
 None
 1.14A 5vlmF-4e3zA:
undetectable		 5vlmF-4e3zA:
23.72