SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4e4d TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
11B
(Mus
musculus) 		4 / 6 SER R  48
ARG R  78
PRO R  25
GLY R  26
 None
 1.19A 2y7pA-4e4dR:
undetectable		 2y7pA-4e4dR:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4e4d TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
11, SOLUBLE FORM
(Mus
musculus) 		4 / 8 ASN X 262
LEU X 237
HIS X 270
ASN X 266
 None
 1.16A 3kp2A-4e4dX:
undetectable
3kp2B-4e4dX:
undetectable		 3kp2A-4e4dX:
22.84
3kp2B-4e4dX:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4e4d TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
11B
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
11, SOLUBLE FORM
(Mus
musculus;
Mus
musculus) 		5 / 12 ASN X 253
GLY X 257
GLU R  95
GLY X 258
SER X 293
 None
 0.91A 3nk7B-4e4dX:
undetectable		 3nk7B-4e4dX:
17.86