SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 7 LEU A 380
ALA A 381
TYR A 384
GLU A 351
 None
 0.58A 1dmaA-4e4fA:
undetectable		 1dmaA-4e4fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 GLY A  32
ALA A  88
GLY A 293
ILE A 294
ILE A  66
 None
 0.81A 1hshA-4e4fA:
undetectable		 1hshA-4e4fA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ASP A 377
ILE A 322
PRO A 321
ILE A 374
THR A  19
 None
 1.19A 1kijA-4e4fA:
undetectable		 1kijA-4e4fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 ARG A 200
ARG A 139
ARG A 233
 None
 1.08A 1l7fA-4e4fA:
undetectable		 1l7fA-4e4fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 ARG A 200
ARG A 139
ARG A 233
 None
 1.10A 1l7hA-4e4fA:
undetectable		 1l7hA-4e4fA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 TRP A 404
VAL A 393
PRO A 392
 None
 0.80A 1rg1A-4e4fA:
1.4		 1rg1A-4e4fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 TRP A 404
VAL A 393
PRO A 392
 None
 0.79A 1rh0A-4e4fA:
undetectable		 1rh0A-4e4fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 393
TRP A 183
TRP A 402
 None
None
GOL  A 505 (-4.6A)
 1.21A 2xdcA-4e4fA:
undetectable
2xdcB-4e4fA:
undetectable		 2xdcA-4e4fA:
2.65
2xdcB-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 TRP A 402
VAL A 393
TRP A 183
 GOL  A 505 (-4.6A)
None
None
 1.20A 2xdcA-4e4fA:
undetectable
2xdcB-4e4fA:
undetectable		 2xdcA-4e4fA:
2.65
2xdcB-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 393
TRP A 183
TRP A 402
 None
None
GOL  A 505 (-4.6A)
 1.29A 2xdcC-4e4fA:
undetectable
2xdcD-4e4fA:
undetectable		 2xdcC-4e4fA:
2.65
2xdcD-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 393
TRP A 183
TRP A 402
 None
None
GOL  A 505 (-4.6A)
 1.22A 2y5mA-4e4fA:
undetectable
2y5mB-4e4fA:
undetectable		 2y5mA-4e4fA:
2.65
2y5mB-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 393
TRP A 183
TRP A 402
 None
None
GOL  A 505 (-4.6A)
 1.21A 2y6nA-4e4fA:
undetectable
2y6nB-4e4fA:
undetectable		 2y6nA-4e4fA:
2.65
2y6nB-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 TRP A 402
VAL A 393
TRP A 183
 GOL  A 505 (-4.6A)
None
None
 1.19A 2y6nA-4e4fA:
undetectable
2y6nB-4e4fA:
undetectable		 2y6nA-4e4fA:
2.65
2y6nB-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 ASP A  33
PHE A 353
SER A 317
 None
 0.99A 3i5uB-4e4fA:
undetectable		 3i5uB-4e4fA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 PRO A 335
PHE A 330
ALA A 301
 None
 0.69A 3itaD-4e4fA:
0.8		 3itaD-4e4fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39A-4e4fA:
undetectable		 3k39A-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39F-4e4fA:
undetectable		 3k39F-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39G-4e4fA:
undetectable		 3k39G-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39H-4e4fA:
undetectable		 3k39H-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39K-4e4fA:
undetectable		 3k39K-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ARG A 147
GLU A 341
ARG A 285
ALA A 172
GLU A 170
 None
FMT  A 506 ( 4.1A)
FMT  A 506 (-4.3A)
None
None
 1.48A 3k39L-4e4fA:
undetectable		 3k39L-4e4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 LEU A 234
HIS A 211
MET A 237
 None
 0.83A 3thrD-4e4fA:
undetectable		 3thrD-4e4fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 GLY A 371
GLY A 373
GLU A 368
ALA A 101
LEU A 108
 None
 1.03A 3vywA-4e4fA:
undetectable		 3vywA-4e4fA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 VAL A 393
TRP A 183
TRP A 402
 None
None
GOL  A 505 (-4.6A)
 1.22A 3zq8A-4e4fA:
undetectable
3zq8B-4e4fA:
undetectable		 3zq8A-4e4fA:
2.65
3zq8B-4e4fA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 TYR A 188
ARG A 216
HIS A 214
 None
None
FMT  A 506 ( 4.7A)
 1.23A 4fubA-4e4fA:
undetectable		 4fubA-4e4fA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 7 HIS A 214
ASP A 212
VAL A 265
GLU A 264
 FMT  A 506 ( 4.7A)
MG  A 504 ( 2.4A)
None
MG  A 504 ( 2.5A)
 1.03A 4hvrA-4e4fA:
undetectable		 4hvrA-4e4fA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 THR A 123
ASN A 206
PHE A 205
 None
 0.81A 4pd9A-4e4fA:
undetectable		 4pd9A-4e4fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 8 PHE A 196
GLY A 226
MET A 213
ILE A 252
 None
 0.96A 4qogA-4e4fA:
undetectable
4qogB-4e4fA:
undetectable		 4qogA-4e4fA:
22.02
4qogB-4e4fA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		3 / 3 PHE A 225
THR A 123
LEU A 234
 None
 0.79A 4qztA-4e4fA:
undetectable		 4qztA-4e4fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 8 LEU A  93
ALA A  60
MET A   1
ILE A   3
 None
 0.68A 4wboB-4e4fA:
undetectable		 4wboB-4e4fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 9 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.20A 5lg3B-4e4fA:
0.4		 5lg3B-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 9 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.22A 5lg3C-4e4fA:
0.4		 5lg3C-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 9 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.17A 5lg3D-4e4fA:
undetectable		 5lg3D-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 10 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.21A 5lg3F-4e4fA:
undetectable		 5lg3F-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 10 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.18A 5lg3G-4e4fA:
undetectable		 5lg3G-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 10 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.20A 5lg3H-4e4fA:
undetectable		 5lg3H-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 4 GLU A 230
THR A 258
THR A 192
LEU A 217
 None
 1.50A 5v96A-4e4fA:
undetectable		 5v96A-4e4fA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		5 / 12 ALA A 198
PHE A 203
THR A 123
ILE A 146
ARG A 139
 None
 1.27A 5z6fA-4e4fA:
undetectable		 5z6fA-4e4fA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4e4f MANNONATE
DEHYDRATASE
(Pectobacterium
carotovorum) 		4 / 6 TRP A 404
LEU A 319
ASP A 239
GLU A 264
 None
None
MG  A 504 (-4.0A)
MG  A 504 ( 2.5A)
 1.49A 6djzC-4e4fA:
undetectable		 6djzC-4e4fA:
21.53