SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 163
LEU A   4
VAL A   7
LEU A   8
ILE A 321
 None
 0.92A 1df7A-4e4rA:
undetectable		 1df7A-4e4rA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ALA A 115
LEU A  81
SER A  75
ILE A  70
PRO A  72
 None
 1.10A 1drfA-4e4rA:
undetectable		 1drfA-4e4rA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 LEU A 299
ASN A 304
ASP A 131
THR A 129
 None
None
None
TRS  A 501 (-4.4A)
 1.03A 1ig3A-4e4rA:
4.2
1ig3B-4e4rA:
undetectable		 1ig3A-4e4rA:
20.72
1ig3B-4e4rA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 PHE A 154
ILE A 163
GLY A 151
ILE A 181
 None
None
None
EDO  A 502 (-4.7A)
 0.98A 2qwxA-4e4rA:
undetectable
2qwxB-4e4rA:
2.2		 2qwxA-4e4rA:
20.94
2qwxB-4e4rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 LYS A  52
GLN A  54
LEU A  56
LEU A  30
 None
 0.56A 3h5gA-4e4rA:
undetectable
3h5gC-4e4rA:
undetectable		 3h5gA-4e4rA:
8.57
3h5gC-4e4rA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 4 ILE A 321
GLN A 325
VAL A 295
PHE A 154
 None
 1.37A 3ieoA-4e4rA:
undetectable		 3ieoA-4e4rA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 GLU A 184
SER A 185
VAL A 183
VAL A 269
 None
 1.33A 3n61A-4e4rA:
undetectable
3n61B-4e4rA:
undetectable		 3n61A-4e4rA:
21.80
3n61B-4e4rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 VAL A  20
GLY A 120
ILE A 140
GLY A 109
 None
 0.76A 3n9jB-4e4rA:
undetectable		 3n9jB-4e4rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 ILE A 181
SER A 150
ILE A 169
ARG A 148
 EDO  A 502 (-4.7A)
EDO  A 502 ( 4.3A)
None
EDO  A 502 (-3.7A)
 1.12A 3sfeB-4e4rA:
undetectable
3sfeC-4e4rA:
undetectable		 3sfeB-4e4rA:
20.65
3sfeC-4e4rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 GLN A 138
PHE A  85
TYR A 107
 None
 1.00A 3ucjA-4e4rA:
undetectable		 3ucjA-4e4rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 LEU A  81
LEU A 102
LEU A  47
LEU A 121
ILE A 139
 None
 1.17A 4dm8A-4e4rA:
undetectable		 4dm8A-4e4rA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 ALA A  32
GLY A  24
LEU A  21
VAL A  46
 None
 0.91A 4dubA-4e4rA:
undetectable		 4dubA-4e4rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 9 GLU A  25
GLY A  24
VAL A  46
PRO A  22
GLY A 109
 None
 1.44A 4fimA-4e4rA:
2.0		 4fimA-4e4rA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ARG A  89
LYS A  90
LYS A  92
 None
 1.29A 4k50A-4e4rA:
undetectable		 4k50A-4e4rA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ARG A  89
LYS A  90
LYS A  92
 None
 1.25A 4k50E-4e4rA:
undetectable		 4k50E-4e4rA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ARG A  89
LYS A  90
LYS A  92
 None
 1.24A 4k50I-4e4rA:
undetectable		 4k50I-4e4rA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 ASN A 304
LEU A   8
ILE A  19
VAL A  42
 None
 0.86A 4ojbA-4e4rA:
undetectable		 4ojbA-4e4rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A  24
LEU A  56
ARG A 308
THR A  34
ILE A  64
 None
 1.32A 4okbA-4e4rA:
undetectable		 4okbA-4e4rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 9 ILE A 237
ALA A 235
ILE A 236
ALA A 199
LEU A 261
 CL  A 507 (-4.8A)
None
CL  A 507 (-4.6A)
None
None
 1.07A 5mvmA-4e4rA:
undetectable
5mvmE-4e4rA:
undetectable		 5mvmA-4e4rA:
12.05
5mvmE-4e4rA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLN A  35
ALA A  32
LEU A  62
ILE A  64
VAL A  46
 None
 1.38A 5vlmB-4e4rA:
undetectable		 5vlmB-4e4rA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.08A 5vooA-4e4rA:
undetectable		 5vooA-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.03A 5vooB-4e4rA:
undetectable		 5vooB-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.09A 5vooC-4e4rA:
undetectable		 5vooC-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.11A 5vooD-4e4rA:
undetectable		 5vooD-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.16A 5vooE-4e4rA:
undetectable		 5vooE-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.15A 5vooF-4e4rA:
undetectable		 5vooF-4e4rA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4e4r PHOSPHATE
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 177
VAL A 133
LEU A 299
GLY A 151
ILE A 169
 EDO  A 502 (-3.7A)
None
None
None
None
 1.08A 5vopA-4e4rA:
undetectable		 5vopA-4e4rA:
23.53