SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Ochotona
princeps) 		5 / 12 GLY A  41
LEU A 118
ILE A 115
ASP A  94
LYS A  67
 GOL  A 201 ( 4.5A)
None
None
None
None
 1.03A 2oxtC-4e4sA:
undetectable		 2oxtC-4e4sA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Ochotona
princeps) 		3 / 3 LEU A  27
MET A  30
ASP A  32
 None
 0.82A 3v5wA-4e4sA:
undetectable		 3v5wA-4e4sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Ochotona
princeps) 		4 / 5 SER A  15
GLY A  11
TRP A  17
ASP A  32
 None
 1.45A 3w9tB-4e4sA:
undetectable		 3w9tB-4e4sA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Ochotona
princeps) 		4 / 5 SER A  15
GLY A  11
TRP A  17
ASP A  32
 None
 1.46A 3w9tC-4e4sA:
undetectable		 3w9tC-4e4sA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18
(Ochotona
princeps) 		4 / 5 SER A  15
GLY A  11
TRP A  17
ASP A  32
 None
 1.45A 3w9tD-4e4sA:
undetectable		 3w9tD-4e4sA:
13.02