SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		4 / 8 SER A 286
SER A 201
ASN A 220
GLN A 219
 None
 1.10A 2cmlC-4e4tA:
undetectable		 2cmlC-4e4tA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		4 / 5 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.98A 2p2fA-4e4tA:
2.8		 2p2fA-4e4tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		4 / 4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.93A 2p2fB-4e4tA:
2.0		 2p2fB-4e4tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 PRO A 342
PHE A 331
ALA A 363
 None
 0.70A 3itaD-4e4tA:
undetectable		 3itaD-4e4tA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 HIS A  58
GLY A  52
GLY A  21
ALA A  61
ALA A  62
 None
 1.22A 3sueB-4e4tA:
undetectable		 3sueB-4e4tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		4 / 6 PHE A  83
SER A  49
HIS A  58
PRO A  45
 None
 1.48A 5dzka-4e4tA:
undetectable
5dzko-4e4tA:
undetectable		 5dzka-4e4tA:
19.51
5dzko-4e4tA:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 VAL A 232
PRO A 233
ALA A 234
PHE A 266
GLN A 246
 None
 1.06A 5hgcA-4e4tA:
undetectable		 5hgcA-4e4tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 ALA A 228
ASN A 324
LEU A 323
 None
 0.38A 5i1pA-4e4tA:
undetectable		 5i1pA-4e4tA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		4 / 8 GLY A  18
ALA A  15
ASP A  56
PHE A  29
 None
 0.88A 5mvsB-4e4tA:
2.8		 5mvsB-4e4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLY A 161
GLY A 166
HIS A 130
GLU A 191
ILE A 114
 None
 1.03A 5wz1A-4e4tA:
undetectable		 5wz1A-4e4tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLY A 161
GLY A 166
HIS A 130
GLU A 191
ILE A 114
 None
 1.03A 5wz1C-4e4tA:
2.0		 5wz1C-4e4tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLY A 161
GLY A 166
HIS A 130
GLU A 191
ILE A 114
 None
 1.04A 5wz1G-4e4tA:
2.0		 5wz1G-4e4tA:
21.36