SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 11 ILE A  32
SER A  10
GLY A   9
GLY A   8
PHE A  45
 None
 1.33A 1ho5A-4e4yA:
undetectable		 1ho5A-4e4yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ILE A  13
GLY A 123
SER A 140
GLY A 168
 GOL  A 306 (-4.8A)
None
None
None
GOL  A 306 (-4.7A)
 1.08A 1kiaA-4e4yA:
6.9		 1kiaA-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ILE A 212
GLY A 123
VAL A 165
SER A 140
 GOL  A 306 (-4.8A)
None
None
None
None
 1.34A 1nbhA-4e4yA:
7.0		 1nbhA-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ILE A  13
GLY A 123
SER A 140
GLY A 168
 GOL  A 306 (-4.8A)
None
None
None
GOL  A 306 (-4.7A)
 1.10A 1nbhB-4e4yA:
6.6		 1nbhB-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ILE A 212
GLY A 123
VAL A 165
SER A 140
 GOL  A 306 (-4.8A)
None
None
None
None
 1.33A 1nbhC-4e4yA:
undetectable		 1nbhC-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ILE A 212
GLY A 123
VAL A 165
SER A 140
 GOL  A 306 (-4.8A)
None
None
None
None
 1.34A 1nbhD-4e4yA:
3.3		 1nbhD-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		6 / 12 TYR A 137
ILE A  13
GLY A 123
VAL A 165
SER A 140
GLY A 168
 GOL  A 306 (-4.8A)
None
None
None
None
GOL  A 306 (-4.7A)
 1.38A 1nbiA-4e4yA:
6.5		 1nbiA-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		6 / 12 TYR A 137
ILE A  13
GLY A 123
VAL A 165
SER A 140
GLY A 168
 GOL  A 306 (-4.8A)
None
None
None
None
GOL  A 306 (-4.7A)
 1.38A 1nbiB-4e4yA:
6.5		 1nbiB-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 5 CYH A 127
TYR A 238
THR A 138
SER A 124
 None
None
None
GOL  A 306 (-2.7A)
 1.42A 1ymxA-4e4yA:
undetectable		 1ymxA-4e4yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 8 VAL A  59
LEU A  97
GLY A   8
ALA A  75
 None
 0.95A 2xfsA-4e4yA:
undetectable		 2xfsA-4e4yA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 7 GLY A   9
VAL A  18
ILE A  32
GLN A  36
 None
 0.91A 3fi0P-4e4yA:
undetectable		 3fi0P-4e4yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 10 VAL A  17
GLN A 210
VAL A 165
VAL A 120
LEU A 220
 None
 1.00A 3gwxA-4e4yA:
undetectable		 3gwxA-4e4yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 4 GLY A 123
VAL A 165
GLY A 229
THR A 228
 None
 0.90A 3ib2A-4e4yA:
undetectable		 3ib2A-4e4yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 10 LYS A  93
SER A 101
SER A 140
ILE A  77
GLY A  76
 None
 1.23A 3ik6B-4e4yA:
undetectable
3ik6E-4e4yA:
undetectable		 3ik6B-4e4yA:
23.40
3ik6E-4e4yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 11 GLY A  76
ALA A  75
GLY A   9
GLY A  14
ILE A  13
 None
 0.89A 3ufnA-4e4yA:
undetectable		 3ufnA-4e4yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 LEU A 109
LEU A   5
ILE A  56
ILE A  63
PHE A  45
 None
 1.14A 4a7aB-4e4yA:
2.7		 4a7aB-4e4yA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 GLY A  14
GLY A   9
GLY A   8
ALA A 213
VAL A 170
 None
 0.88A 4htfA-4e4yA:
4.3		 4htfA-4e4yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 5 GLY A 108
LEU A  73
ILE A 103
LEU A 151
 None
 0.71A 4o8fA-4e4yA:
undetectable		 4o8fA-4e4yA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 4 TYR A 238
ILE A 129
THR A 239
TYR A 137
 None
None
None
GOL  A 306 (-4.8A)
 1.14A 4oltA-4e4yA:
1.0		 4oltA-4e4yA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 7 GLY A  76
ALA A  75
GLY A  14
ILE A  13
 None
 0.66A 5kqyB-4e4yA:
undetectable		 5kqyB-4e4yA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 8 GLY A  76
ALA A  75
GLY A  14
ILE A  13
 None
 0.62A 5kr1B-4e4yA:
undetectable		 5kr1B-4e4yA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ILE A 144
ILE A  91
VAL A  94
LEU A  95
VAL A  99
 None
 0.83A 5mueA-4e4yA:
undetectable		 5mueA-4e4yA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 7 ASN A 163
ILE A 234
LEU A 215
LEU A 219
PRO A 233
 None
 1.36A 5u4sA-4e4yA:
24.3		 5u4sA-4e4yA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 6 PHE A 201
GLY A 168
GLN A 126
TYR A 137
 None
GOL  A 306 (-4.7A)
GOL  A 306 (-4.0A)
GOL  A 306 (-4.8A)
 1.27A 6ag0A-4e4yA:
undetectable		 6ag0A-4e4yA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 6 PHE A 201
GLY A 168
GLN A 126
TYR A 137
 None
GOL  A 306 (-4.7A)
GOL  A 306 (-4.0A)
GOL  A 306 (-4.8A)
 1.29A 6ag0C-4e4yA:
undetectable		 6ag0C-4e4yA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 TYR A 137
ALA A 143
ALA A 145
THR A 164
ILE A  13
 GOL  A 306 (-4.8A)
None
None
None
None
 1.22A 6aybA-4e4yA:
undetectable		 6aybA-4e4yA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 VAL A  59
ILE A  63
SER A  10
VAL A   6
ILE A  30
 None
 1.43A 6gsdA-4e4yA:
18.1		 6gsdA-4e4yA:
15.45