SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		10 / 10 GLU A  90
THR A  92
TYR A 114
ARG A 120
GLN A 134
GLU A 138
ARG A 265
TYR A 269
TYR A 270
GLY A 291
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
 0.53A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 10 GLU A  90
THR A  92
TYR A 114
GLU A 138
TYR A 269
TYR A 270
GLY A 292
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
None
 1.00A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 10 GLU A 138
THR A  92
TYR A 269
GLU A  90
TYR A 114
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-3.6A)
None
 1.43A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 10 TYR A 114
ARG A 120
GLN A 134
GLU A 138
TYR A 270
 None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
 1.10A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 0.57A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
THR A  92
GLN A 134
TYR A 269
GLY A 291
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
 1.19A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.17A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.54A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.14A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.21A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.99A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 THR A  92
GLN A 134
TYR A 269
GLY A 291
ALA A 312
 HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 ( 3.8A)
 1.21A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.54A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		6 / 12 GLU A  90
THR A  92
GLN A 134
TYR A 269
GLY A 291
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 ( 3.8A)
 1.33A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.08A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 10 VAL A  95
LEU A 297
TYR A 269
LEU A 267
TYR A 114
 None
 1.38A 1j78B-4e51A:
0.0		 1j78B-4e51A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 8 SER A 368
TYR A 337
HIS A 340
HIS A 366
 None
 1.08A 2bteD-4e51A:
undetectable		 2bteD-4e51A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  68
PHE A 132
GLN A 134
ALA A 312
GLU A  72
 None
None
HIS  A 501 (-3.4A)
HIS  A 501 ( 3.8A)
None
 1.42A 2vppB-4e51A:
undetectable		 2vppB-4e51A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		3 / 3 CYH A 309
PRO A 109
ASP A 146
 None
 0.97A 3hlwB-4e51A:
undetectable		 3hlwB-4e51A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 VAL A 392
LEU A 433
VAL A 334
GLY A 387
ALA A 388
 None
 1.02A 3pghC-4e51A:
undetectable		 3pghC-4e51A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 7 SER A 368
TYR A 337
HIS A 340
HIS A 366
 None
 1.20A 4arcA-4e51A:
undetectable		 4arcA-4e51A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.79A 4o2bD-4e51A:
undetectable		 4o2bD-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		3 / 3 CYH A 309
PRO A 109
ASP A 146
 None
 0.97A 4pm5A-4e51A:
undetectable		 4pm5A-4e51A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 7 GLU A 138
TYR A 269
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-2.7A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 1.14A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		6 / 7 THR A  92
GLU A 138
ARG A 265
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 1.15A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 7 THR A  92
GLU A 138
GLY A 292
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-3.3A)
 0.81A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 7 THR A  92
GLU A 138
TYR A 270
TYR A 294
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 0.70A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 4 GLY A 310
LEU A 250
PHE A 257
ILE A 171
 HIS  A 501 (-3.3A)
None
None
None
 0.98A 4xv2A-4e51A:
undetectable		 4xv2A-4e51A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 7 VAL A 352
LEU A 429
SER A 428
GLU A 427
 None
 0.96A 4zphA-4e51A:
undetectable
4zphB-4e51A:
undetectable		 4zphA-4e51A:
20.77
4zphB-4e51A:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 ARG A 120
GLN A 134
GLU A 138
LEU A 267
TYR A 270
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 1.44A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.37A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.11A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.20A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.87A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 11 ARG A 120
GLN A 134
GLU A 138
TYR A 270
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 1.34A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		11 / 11 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.39A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 11 GLU A  90
THR A  92
GLU A 138
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.17A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.24A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.90A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.78A 5eypB-4e51A:
undetectable		 5eypB-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 VAL A 255
LEU A 250
ALA A 149
MET A 313
LEU A  39
 None
 1.14A 5hbsA-4e51A:
undetectable		 5hbsA-4e51A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.88A 5nm5B-4e51A:
undetectable		 5nm5B-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.83A 5xiwB-4e51A:
undetectable		 5xiwB-4e51A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 267
ILE A  62
GLY A  63
ASP A  67
ILE A  68
 None
 1.01A 6emuA-4e51A:
undetectable		 6emuA-4e51A:
18.38