SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASP B 135
GLY B 130
SER B 176
THR B 180
 None
 0.85A 1m4iA-4e54B:
undetectable		 1m4iA-4e54B:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA B 259
THR B 260
VAL B 267
ALA B 293
THR B 305
 None
 1.24A 1r55A-4e54B:
undetectable		 1r55A-4e54B:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE B 110
PHE B 186
LEU B 162
GLY B 130
 None
 1.02A 2v0mC-4e54B:
undetectable		 2v0mC-4e54B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLU B  29
ARG B  25
GLU B  31
SER B  82
 None
 1.21A 2zt7A-4e54B:
undetectable		 2zt7A-4e54B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 GLY B 157
GLY B 154
GLY B 152
GLY B 133
 None
 0.61A 3bogD-4e54B:
undetectable		 3bogD-4e54B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASP B 373
GLN B 385
MET B 382
GLU B 368
 None
 1.09A 3dh0A-4e54B:
undetectable		 3dh0A-4e54B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ASN B 292
HIS B 247
VAL B 248
 None
 0.87A 3elzB-4e54B:
undetectable		 3elzB-4e54B:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 GLU B 311
PRO B 328
ARG B 288
HIS B 289
 None
 1.46A 3ltwA-4e54B:
undetectable		 3ltwA-4e54B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER B 297
LEU B 324
ALA B 317
ILE B 269
ALA B 259
 None
 1.05A 3nxuA-4e54B:
undetectable		 3nxuA-4e54B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU B 258
ASP B 208
ALA B 294
PHE B 296
CYH B 295
 None
 1.50A 3r2jB-4e54B:
undetectable		 3r2jB-4e54B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE B  94
GLN B  88
PHE B 400
 None
 0.84A 3rv5A-4e54B:
undetectable		 3rv5A-4e54B:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ASN B 292
HIS B 247
GLY B 161
SER B 175
GLY B 223
 None
 1.20A 4a99A-4e54B:
undetectable		 4a99A-4e54B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASN B 292
HIS B 247
GLY B 161
SER B 175
GLY B 223
 None
 1.22A 4a99C-4e54B:
undetectable		 4a99C-4e54B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASN B 292
HIS B 247
GLY B 161
SER B 175
GLY B 223
 None
 1.19A 4a99D-4e54B:
undetectable		 4a99D-4e54B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 THR B 246
THR B 260
ALA B 259
THR B 305
 None
 1.04A 4qw0Y-4e54B:
undetectable		 4qw0Y-4e54B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 TRP B 270
THR B 260
THR B 266
SER B 262
 None
 1.40A 5b6iB-4e54B:
undetectable		 5b6iB-4e54B:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 VAL B 353
GLY B 354
ARG B 355
PHE B 375
 None
 1.09A 5d4nA-4e54B:
undetectable
5d4nC-4e54B:
undetectable		 5d4nA-4e54B:
12.64
5d4nC-4e54B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.44A 5n0rA-4e54B:
undetectable		 5n0rA-4e54B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.42A 5n0sA-4e54B:
undetectable		 5n0sA-4e54B:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.42A 5n0tA-4e54B:
undetectable		 5n0tA-4e54B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.43A 5n0wA-4e54B:
undetectable		 5n0wA-4e54B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 SER B 409
ALA B 408
GLN B 105
THR B 406
 None
 1.42A 5n0xA-4e54B:
undetectable		 5n0xA-4e54B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER B 297
LEU B 324
ALA B 317
ILE B 269
ALA B 259
 None
 1.08A 5vc0A-4e54B:
undetectable		 5vc0A-4e54B:
20.43