SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 LEU A  19
ARG A 306
ALA A 309
LEU A 313
ALA A 317
 None
 0.84A 1fk6A-4e5kA:
undetectable		 1fk6A-4e5kA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		3 / 3 ALA A 159
THR A 101
PHE A 150
 None
NAD  A 401 ( 4.8A)
None
 0.63A 2c6nB-4e5kA:
undetectable		 2c6nB-4e5kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 ILE A 156
GLY A 157
GLY A 152
LEU A 208
PRO A 235
 NAD  A 401 (-3.6A)
None
NAD  A 401 (-3.3A)
NAD  A 401 (-4.5A)
None
 1.22A 2y7kD-4e5kA:
undetectable		 2y7kD-4e5kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		4 / 8 PHE A  52
ALA A  74
ALA A 308
LEU A  19
 None
 0.90A 3l4dA-4e5kA:
undetectable		 3l4dA-4e5kA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 10 LEU A   5
PHE A  52
ALA A  51
GLY A  72
ILE A 312
 None
 1.07A 3qpsA-4e5kA:
undetectable		 3qpsA-4e5kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 ILE A 109
VAL A 148
VAL A 241
LEU A 208
VAL A 240
 None
None
None
NAD  A 401 (-4.5A)
None
 1.13A 3w68B-4e5kA:
undetectable		 3w68B-4e5kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 ILE A 156
PHE A 289
LEU A 250
LEU A 281
LEU A 206
 NAD  A 401 (-3.6A)
None
None
None
None
 1.25A 4j03A-4e5kA:
3.2		 4j03A-4e5kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		4 / 7 PRO A 235
GLU A 266
ASP A  31
THR A  33
 None
 1.11A 4uacA-4e5kA:
undetectable		 4uacA-4e5kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		3 / 3 PRO A  66
ARG A  44
GLU A  67
 None
 0.90A 5j6hA-4e5kA:
undetectable		 5j6hA-4e5kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 ASP A 267
LEU A 222
PRO A 209
ARG A 237
LEU A 208
 None
None
NAD  A 401 (-3.7A)
SO3  A 402 ( 2.6A)
NAD  A 401 (-4.5A)
 1.33A 5syfB-4e5kA:
undetectable		 5syfB-4e5kA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		3 / 3 GLU A 196
HIS A 174
VAL A 192
 None
NAD  A 401 (-4.6A)
None
 0.92A 5trqB-4e5kA:
undetectable		 5trqB-4e5kA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 12 PHE A 203
LEU A 205
GLY A 168
ALA A 169
LEU A 171
 None
 0.87A 5zwrA-4e5kA:
undetectable		 5zwrA-4e5kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)
(Pseudomonas
stutzeri) 		5 / 10 LEU A  62
VAL A  91
VAL A  57
ALA A  51
THR A   8
 None
 1.32A 6h1lA-4e5kA:
undetectable		 6h1lA-4e5kA:
21.65