SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		5 / 11 GLU A 229
LEU A 231
PRO A 230
HIS A 194
GLY A 248
 None
 1.37A 1mjqI-4e5vA:
undetectable
1mjqJ-4e5vA:
undetectable		 1mjqI-4e5vA:
15.19
1mjqJ-4e5vA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		3 / 3 MET A 260
ASN A  37
GLN A  42
 None
 1.03A 1xoqB-4e5vA:
undetectable		 1xoqB-4e5vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 PHE A 289
VAL A 285
TRP A 192
GLY A 187
 None
None
None
EDO  A 407 ( 4.7A)
 0.93A 2gssA-4e5vA:
undetectable		 2gssA-4e5vA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 PHE A 289
VAL A 285
TRP A 192
GLY A 187
 None
None
None
EDO  A 407 ( 4.7A)
 0.93A 2gssB-4e5vA:
undetectable		 2gssB-4e5vA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 7 HIS A 194
LEU A 175
LEU A 247
LEU A 231
 None
 0.87A 3bgdB-4e5vA:
undetectable		 3bgdB-4e5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 PHE A 289
VAL A 285
TRP A 192
GLY A 187
 None
None
None
EDO  A 407 ( 4.7A)
 0.93A 3n9jA-4e5vA:
undetectable		 3n9jA-4e5vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		3 / 3 LEU A 231
ARG A 202
ASN A 120
 None
None
EDO  A 403 (-3.3A)
 0.78A 3qxvD-4e5vA:
undetectable		 3qxvD-4e5vA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		5 / 6 SER A 144
SER A 123
TRP A 137
GLY A 136
GLY A 164
 None
None
EDO  A 403 (-3.8A)
None
None
 1.43A 3rxfA-4e5vA:
undetectable		 3rxfA-4e5vA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		3 / 3 GLN A 261
THR A 254
THR A 253
 None
 0.74A 4fu9A-4e5vA:
undetectable		 4fu9A-4e5vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		3 / 3 GLN A 261
THR A 254
THR A 253
 None
 0.78A 4fufA-4e5vA:
undetectable		 4fufA-4e5vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 PHE A 265
THR A 245
VAL A 113
PHE A 243
 None
 0.96A 4ltwA-4e5vA:
undetectable		 4ltwA-4e5vA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		5 / 12 GLY A  35
HIS A  45
ASP A  88
SER A  93
ASN A  37
 None
 1.26A 4pooA-4e5vA:
undetectable		 4pooA-4e5vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		5 / 12 GLY A  35
HIS A  45
ASP A  88
SER A  93
ASN A  37
 None
 1.27A 4pooB-4e5vA:
undetectable		 4pooB-4e5vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 6 LEU A 270
PHE A 265
THR A 245
VAL A 113
 None
 1.12A 4udaA-4e5vA:
undetectable		 4udaA-4e5vA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 GLU A  97
PHE A  75
GLY A  74
THR A  34
 None
EDO  A 406 ( 4.8A)
None
None
 0.97A 5flcB-4e5vA:
undetectable		 5flcB-4e5vA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 8 GLU A  97
PHE A  75
GLY A  74
THR A  34
 None
EDO  A 406 ( 4.8A)
None
None
 0.97A 5flcF-4e5vA:
undetectable		 5flcF-4e5vA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4e5v PUTATIVE THUA-LIKE
PROTEIN
(Parabacteroides
merdae) 		4 / 6 ASP A 119
LEU A  48
SER A  44
PHE A 265
 None
 1.21A 6ekuA-4e5vA:
undetectable		 6ekuA-4e5vA:
16.88