SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
 None
 0.35A 1bx4A-4e69A:
30.5		 1bx4A-4e69A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.12A 1hvyB-4e69A:
undetectable		 1hvyB-4e69A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 11 LEU A 116
ALA A 119
MET A 120
LEU A 148
GLN A 150
 None
 1.36A 1iiuA-4e69A:
undetectable		 1iiuA-4e69A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 10 GLY A 225
VAL A 229
VAL A 242
ALA A 254
ALA A 283
 None
 0.42A 1likA-4e69A:
31.8		 1likA-4e69A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 THR A  33
ASP A 256
GLY A  28
ILE A 135
ALA A 110
 None
 1.27A 1oltA-4e69A:
undetectable		 1oltA-4e69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 5 GLY A 284
GLN A 285
VAL A 294
SER A 257
 None
 1.29A 1zzqB-4e69A:
undetectable		 1zzqB-4e69A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 5 GLY A 284
GLN A 285
VAL A 294
SER A 257
 None
 1.33A 1zzuA-4e69A:
undetectable		 1zzuA-4e69A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 LEU A 136
LEU A 144
ARG A 101
LEU A   4
VAL A 126
 None
None
GOL  A 407 (-3.9A)
None
None
 1.13A 2qd4A-4e69A:
3.4		 2qd4A-4e69A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 8 THR A  30
MET A  61
ASP A  29
SER A 129
 None
 1.13A 2xytE-4e69A:
undetectable		 2xytE-4e69A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 LEU A 190
ALA A 281
GLY A 255
VAL A 125
ILE A 188
 None
 1.06A 3c6gA-4e69A:
undetectable		 3c6gA-4e69A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 9 ASP A 256
SER A 129
ILE A 179
LEU A 164
ASP A 195
 None
 1.26A 3m0wG-4e69A:
undetectable
3m0wH-4e69A:
undetectable
3m0wI-4e69A:
undetectable
3m0wJ-4e69A:
undetectable		 3m0wG-4e69A:
11.55
3m0wH-4e69A:
11.55
3m0wI-4e69A:
11.55
3m0wJ-4e69A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 LEU A 145
ILE A 179
GLY A 182
ALA A 183
SER A 186
 None
 0.81A 3n8zB-4e69A:
undetectable		 3n8zB-4e69A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 5 ASP A 161
ASP A 256
ASP A  29
ARG A 165
 None
 1.01A 3naiC-4e69A:
1.1		 3naiC-4e69A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		3 / 3 ASP A  29
GLU A   8
GLY A   7
 None
 0.59A 3w9tA-4e69A:
undetectable		 3w9tA-4e69A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 8 ARG A 141
LEU A 144
TYR A 212
THR A 178
 CL  A 404 (-3.2A)
None
None
None
 1.29A 3wipF-4e69A:
undetectable
3wipJ-4e69A:
undetectable		 3wipF-4e69A:
20.36
3wipJ-4e69A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.17A 4eb4A-4e69A:
undetectable		 4eb4A-4e69A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.17A 4eb4B-4e69A:
undetectable		 4eb4B-4e69A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 6 LEU A 190
THR A 157
ALA A 159
SER A 129
 None
 0.72A 4pwjA-4e69A:
undetectable		 4pwjA-4e69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 10 SER A  50
THR A  30
ASP A 161
ASP A 256
GLY A  28
 None
 1.42A 4qb9C-4e69A:
undetectable		 4qb9C-4e69A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 SER A  50
THR A  30
ASP A 161
ASP A 256
GLY A  28
 None
 1.36A 4qb9E-4e69A:
undetectable		 4qb9E-4e69A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ALA A 147
LEU A 116
ALA A 159
ILE A 158
LEU A 133
 None
 0.95A 4r3aB-4e69A:
undetectable		 4r3aB-4e69A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 11 LEU A  37
LEU A 262
ALA A 159
VAL A 125
ILE A 188
 None
 0.91A 4x20D-4e69A:
5.5		 4x20D-4e69A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
 None
 0.31A 5kb6A-4e69A:
14.7		 5kb6A-4e69A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 GLY A 225
VAL A 242
ALA A 254
GLY A 255
ALA A 283
 None
 0.35A 5kb6B-4e69A:
31.9		 5kb6B-4e69A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.15A 5x66A-4e69A:
undetectable
5x66B-4e69A:
undetectable		 5x66A-4e69A:
20.17
5x66B-4e69A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 9 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.13A 5x66C-4e69A:
undetectable		 5x66C-4e69A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 10 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.14A 5x66D-4e69A:
undetectable		 5x66D-4e69A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 ILE A 276
ASP A 264
GLY A 261
PHE A 258
ALA A 268
 None
 1.14A 5x66F-4e69A:
undetectable		 5x66F-4e69A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 LEU A  75
GLY A   7
ALA A  51
PHE A 128
THR A  30
 None
 1.20A 5x6yC-4e69A:
undetectable		 5x6yC-4e69A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		4 / 6 PRO A 226
GLY A 225
ASN A 224
LYS A 223
 None
 0.95A 5xxiA-4e69A:
undetectable		 5xxiA-4e69A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 GLY A 255
GLY A 284
ASN A 259
ASP A 256
ASN A  32
 None
 1.23A 5yniA-4e69A:
3.6		 5yniA-4e69A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 GLY A 255
GLY A 284
ASN A 259
ASP A 256
ASN A  32
 None
 1.22A 5ynmA-4e69A:
3.5		 5ynmA-4e69A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 VAL A 222
VAL A 229
ASP A 187
ASN A 259
VAL A 266
 None
 1.22A 6iblB-4e69A:
undetectable		 6iblB-4e69A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE
(Oceanicola
granulosus) 		5 / 12 VAL A 222
VAL A 229
ASP A 187
PHE A 258
ASN A 259
 None
 1.22A 6iblB-4e69A:
undetectable		 6iblB-4e69A:
22.87