SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.45A 1q6iB-4e6fA:
undetectable		 1q6iB-4e6fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 8 ILE A 104
ASP A 180
ARG A  75
GLU A 102
 None
 0.93A 2cdqA-4e6fA:
undetectable		 2cdqA-4e6fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 ALA A  97
LEU A  76
GLY A 100
THR A 178
 None
None
EDO  A 403 (-4.7A)
None
 0.86A 3dl9A-4e6fA:
undetectable		 3dl9A-4e6fA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.46A 3ihzA-4e6fA:
undetectable		 3ihzA-4e6fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 ARG A 175
THR A 155
ASP A 156
GLU A  43
 None
 1.42A 3v5vC-4e6fA:
undetectable
3v5vD-4e6fA:
undetectable		 3v5vC-4e6fA:
18.57
3v5vD-4e6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 GLU A  43
ARG A 175
THR A 155
ASP A 156
 None
 1.40A 4e7cA-4e6fA:
undetectable
4e7cB-4e6fA:
undetectable		 4e7cA-4e6fA:
18.57
4e7cB-4e6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.45A 4qt3A-4e6fA:
undetectable		 4qt3A-4e6fA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 7 GLU A  43
ILE A 154
ARG A 139
ILE A 138
 None
None
EDO  A 403 ( 4.9A)
None
 0.96A 4xumA-4e6fA:
undetectable		 4xumA-4e6fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.43A 6mkeC-4e6fA:
undetectable		 6mkeC-4e6fA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4e6f UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 TYR A  36
ASP A 180
VAL A  41
ILE A 154
ILE A 104
 None
 1.43A 6mkeD-4e6fA:
undetectable		 6mkeD-4e6fA:
19.11